Expression analysis of IFNAR1 and TYK2 transcripts in COVID-19 patients.
Biomarker
COVID-19
Expression
IFNAR1
TYK2
Journal
Cytokine
ISSN: 1096-0023
Titre abrégé: Cytokine
Pays: England
ID NLM: 9005353
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
received:
10
12
2021
revised:
28
02
2022
accepted:
01
03
2022
pubmed:
27
3
2022
medline:
15
4
2022
entrez:
26
3
2022
Statut:
ppublish
Résumé
As a member of JAK family of non-receptor tyrosine kinases, TYK2 has a crucial role in regulation of immune responses. This protein has a crucial role in constant expression of IFNAR1 on surface of cells and initiation of type I IFN signaling. In the current study, we measured expression of IFNAR1 and TYK2 levels in venous blood samples of COVID-19 patients and matched controls. TYK2 was significantly down-regulated in male patients compared with male controls (RME = 0.34, P value = 0.03). Though, levels of TYK2 were not different between female cases and female controls, or between ICU-admitted and non-ICU-admitted cases. Expression of IFNAR1 was not different either between COVID-19 cases and controls or between patients required ICU admission and non-ICU-admitted cases. However, none of these transcripts can properly diffrentiate COVID-19 cases from controls or separate patients based on disease severity. The current study proposes down-regulation of TYK2 as a molecular mechanism for incapacity of SARS-CoV-2 in induction of a competent IFN response.
Identifiants
pubmed: 35339044
pii: S1043-4666(22)00058-8
doi: 10.1016/j.cyto.2022.155849
pmc: PMC8894869
pii:
doi:
Substances chimiques
IFNAR1 protein, human
0
Proteins
0
Receptor, Interferon alpha-beta
156986-95-7
TYK2 Kinase
EC 2.7.10.2
TYK2 protein, human
EC 2.7.10.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
155849Informations de copyright
Copyright © 2022. Published by Elsevier Ltd.
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