Functions of animal microRNA-encoded peptides: the race is on!
Journal
EMBO reports
ISSN: 1469-3178
Titre abrégé: EMBO Rep
Pays: England
ID NLM: 100963049
Informations de publication
Date de publication:
04 05 2022
04 05 2022
Historique:
received:
04
02
2022
accepted:
04
03
2022
pubmed:
29
3
2022
medline:
6
5
2022
entrez:
28
3
2022
Statut:
ppublish
Résumé
Short open reading frame (sORF)-encoded peptides (SEPs) recently emerged as new key players in biology. Pioneering work first established that sORFs encoded by long non-coding RNAs (lncRNAs) are efficiently translated and produce functional peptides. In plants, primary transcripts of microRNAs (pri-miRNAs) also produce sORF-encoded peptides called miPEPs, which are involved in specific transcriptional autoregulatory feedback loops (Lauressergues et al, 2015). To what extend are such mechanisms conserved in other species, especially in animals? In this issue of EMBO reports, Zhou et al show that pri-miR-31 encodes a miPEP promoting Treg differentiation and downregulating pri-miR-31 expression (Zhou et al, 2022).
Identifiants
pubmed: 35343609
doi: 10.15252/embr.202254789
pmc: PMC9066062
doi:
Substances chimiques
MicroRNAs
0
Peptides
0
RNA, Long Noncoding
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e54789Informations de copyright
© 2022 The Authors.
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