Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity.


Journal

Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724

Informations de publication

Date de publication:
27 04 2022
Historique:
pubmed: 29 3 2022
medline: 30 4 2022
entrez: 28 3 2022
Statut: ppublish

Résumé

The spike protein (S) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) directs infection of the lungs and other tissues following its binding to the angiotensin-converting enzyme 2 (ACE2) receptor. For effective infection, the S protein is cleaved at two sites: S1/S2 and S2'. The "priming" of the surface S protein at S1/S2 (P

Identifiants

pubmed: 35343766
doi: 10.1128/jvi.00128-22
pmc: PMC9044946
doi:

Substances chimiques

Spike Glycoprotein, Coronavirus 0
spike protein, SARS-CoV-2 0
Angiotensin-Converting Enzyme 2 EC 3.4.17.23
Serine Endopeptidases EC 3.4.21.-
TMPRSS2 protein, human EC 3.4.21.-
Furin EC 3.4.21.75

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0012822

Subventions

Organisme : Gouvernement du Canada | Canadian Institutes of Health Research (IRSC)
ID : 148363
Organisme : Gouvernement du Canada | Canadian Institutes of Health Research (IRSC)
ID : 154324
Organisme : Gouvernement du Canada | Canadian Institutes of Health Research (IRSC)
ID : 950-231335
Organisme : Gouvernement du Canada | Canadian Institutes of Health Research (IRSC)
ID : HAL 157986

Commentaires et corrections

Type : ErratumIn

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Auteurs

Rachid Essalmani (R)

Laboratory of Biochemical Neuroendocrinology, Montreal Clinical Research Institute (IRCM), Montreal, Quebec, Canada.

Jaspreet Jain (J)

Laboratory of Human Retrovirology, Montreal Clinical Research Institute (IRCM), Montreal, Quebec, Canada.

Delia Susan-Resiga (D)

Laboratory of Biochemical Neuroendocrinology, Montreal Clinical Research Institute (IRCM), Montreal, Quebec, Canada.

Ursula Andréo (U)

Laboratory of Biochemical Neuroendocrinology, Montreal Clinical Research Institute (IRCM), Montreal, Quebec, Canada.
Laboratory of Human Retrovirology, Montreal Clinical Research Institute (IRCM), Montreal, Quebec, Canada.

Alexandra Evagelidis (A)

Laboratory of Biochemical Neuroendocrinology, Montreal Clinical Research Institute (IRCM), Montreal, Quebec, Canada.

Rabeb Mouna Derbali (RM)

Laboratory of Biochemical Neuroendocrinology, Montreal Clinical Research Institute (IRCM), Montreal, Quebec, Canada.

David N Huynh (DN)

Laboratory of Biochemical Neuroendocrinology, Montreal Clinical Research Institute (IRCM), Montreal, Quebec, Canada.

Frédéric Dallaire (F)

Laboratory of Human Retrovirology, Montreal Clinical Research Institute (IRCM), Montreal, Quebec, Canada.

Mélanie Laporte (M)

Laboratory of Human Retrovirology, Montreal Clinical Research Institute (IRCM), Montreal, Quebec, Canada.

Adrien Delpal (A)

AFMB, CNRS, Aix-Marseille University, CNRS, UMR 7257, Case 925, Marseille, France.

Priscila Sutto-Ortiz (P)

AFMB, CNRS, Aix-Marseille University, CNRS, UMR 7257, Case 925, Marseille, France.

Bruno Coutard (B)

Unité des Virus Émergents (UVE), Aix-Marseille University, IRD 190, INSERM 1207, IHU Méditerranée Infection, Marseille, France.

Claudine Mapa (C)

Boston Pharmaceuticals, Translational Research, Cambridge, Massachusetts, USA.

Keith Wilcoxen (K)

Boston Pharmaceuticals, Translational Research, Cambridge, Massachusetts, USA.

Etienne Decroly (E)

AFMB, CNRS, Aix-Marseille University, CNRS, UMR 7257, Case 925, Marseille, France.

Tram Nq Pham (T)

Laboratory of Human Retrovirology, Montreal Clinical Research Institute (IRCM), Montreal, Quebec, Canada.

Éric A Cohen (ÉA)

Laboratory of Human Retrovirology, Montreal Clinical Research Institute (IRCM), Montreal, Quebec, Canada.
Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montreal, Quebec, Canada.

Nabil G Seidah (NG)

Laboratory of Biochemical Neuroendocrinology, Montreal Clinical Research Institute (IRCM), Montreal, Quebec, Canada.

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Classifications MeSH