Reduced cortical cholinergic innervation measured using [

Alzheimer Disease / diagnosis Amyloid beta-Peptides Basal Forebrain Cholinergic Agents Cognitive Dysfunction / diagnostic imaging Dementia Humans Magnetic Resonance Imaging Piperidines Positron-Emission Tomography / methods
Basal forebrain Cholinergic system FEOBV MRI Mild cognitive impairment PET imaging

Journal

NeuroImage. Clinical
ISSN: 2213-1582
Titre abrégé: Neuroimage Clin
Pays: Netherlands
ID NLM: 101597070

Informations de publication

Date de publication:
2022
Historique:
received: 19 12 2021
revised: 06 03 2022
accepted: 22 03 2022
pubmed: 29 3 2022
medline: 20 5 2022
entrez: 28 3 2022
Statut: ppublish

Résumé

Dysfunction of the cholinergic basal forebrain (BF) neurotransmitter system, including cholinergic axon denervation of the cortex, plays an important role in cognitive decline and dementia. A validated method to directly quantify cortical cholinergic terminal integrity enables exploration of the involvement of this system in diverse cognitive profiles associated with dementia, particularly at a prodromal stage. In this study, we used the radiotracer [

Identifiants

DOI: 10.1016/j.nicl.2022.102992 PMID: 35344804 PMC: PMC8958543
pubmed: 35344804
pii: S2213-1582(22)00057-2
doi: 10.1016/j.nicl.2022.102992
pmc: PMC8958543
pii:
doi:

Substances chimiques

Amyloid beta-Peptides 0
Cholinergic Agents 0
Piperidines 0
fluoroethoxy-benzovesamicol 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

102992

Informations de copyright

Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.

Auteurs

Ying Xia (Y)

The Australian e-Health Research Centre, CSIRO Health and Biosecurity, Brisbane, QLD, Australia. Electronic address: ying.xia@csiro.au.

Eamonn Eeles (E)

Internal Medicine Service, The Prince Charles Hospital, Brisbane, QLD, Australia; School of Medicine, Northside Clinical School, The Prince Charles Hospital, Brisbane, QLD, Australia; Dementia & Neuro Mental Health Research Unit, UQCCR, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia.

Jurgen Fripp (J)

The Australian e-Health Research Centre, CSIRO Health and Biosecurity, Brisbane, QLD, Australia.

Donna Pinsker (D)

Internal Medicine Service, The Prince Charles Hospital, Brisbane, QLD, Australia; School of Psychology, The University of Queensland, Brisbane, QLD, Australia.

Paul Thomas (P)

Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia.

Melissa Latter (M)

Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia.

Vincent Doré (V)

The Australian e-Health Research Centre, CSIRO Health and Biosecurity, Brisbane, QLD, Australia; Austin Health, Melbourne, VIC, Australia.

Amir Fazlollahi (A)

The Australian e-Health Research Centre, CSIRO Health and Biosecurity, Brisbane, QLD, Australia; Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.

Pierrick Bourgeat (P)

The Australian e-Health Research Centre, CSIRO Health and Biosecurity, Brisbane, QLD, Australia.

Victor L Villemagne (VL)

Austin Health, Melbourne, VIC, Australia; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.

Elizabeth J Coulson (EJ)

Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia; School of Biomedical Sciences, The University of Queensland, Brisbane, QLD, Australia.

Stephen Rose (S)

The Australian e-Health Research Centre, CSIRO Health and Biosecurity, Brisbane, QLD, Australia.

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Reduced cortical cholinergic innervation...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › Reduced cortical cholinergic innervation...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex olfactif › Prosencéphale basal › Reduced cortical cholinergic innervation...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents cholinergiques › Reduced cortical cholinergic innervation...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › Reduced cortical cholinergic innervation...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Reduced cortical cholinergic innervation...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Reduced cortical cholinergic innervation...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Reduced cortical cholinergic innervation...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pipéridines › Reduced cortical cholinergic innervation...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Reduced cortical cholinergic innervation...