Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43.

Amyloid / ultrastructure Cryoelectron Microscopy DNA-Binding Proteins / metabolism Frontotemporal Lobar Degeneration / metabolism Humans Membrane Proteins / metabolism Nerve Tissue Proteins / metabolism

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
05 2022
Historique:
received: 25 09 2021
accepted: 22 03 2022
pubmed: 29 3 2022
medline: 18 5 2022
entrez: 28 3 2022
Statut: ppublish

Résumé

Frontotemporal lobar degeneration (FTLD) is the third most common neurodegenerative condition after Alzheimer's and Parkinson's diseases

Identifiants

DOI: 10.1038/s41586-022-04670-9 PMID: 35344984 PMC: PMC9844993
pubmed: 35344984
doi: 10.1038/s41586-022-04670-9
pii: 10.1038/s41586-022-04670-9
pmc: PMC9844993
mid: NIHMS1858738
doi:

Substances chimiques

Amyloid 0
DNA-Binding Proteins 0
Membrane Proteins 0
Nerve Tissue Proteins 0
TARDBP protein, human 0
TMEM106B protein, human 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

304-309

Subventions

Organisme : NIA NIH HHS
ID : R01 AG048120
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG063911
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM103479
Pays : United States
Organisme : NIH HHS
ID : S10 OD018111
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007185
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG003949
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR023057
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG048120
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG070895
Pays : United States
Organisme : NINDS NIH HHS
ID : P01 NS084974
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG070895
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG062677
Pays : United States

Informations de copyright

© 2022. The Author(s), under exclusive licence to Springer Nature Limited.

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Auteurs

Yi Xiao Jiang (YX)

Departments of Chemistry and Biochemistry and Biological Chemistry, UCLA-DOE Institute, and Molecular Biology Institute, UCLA, Los Angeles, CA, USA.
Howard Hughes Medical Institute, UCLA, Los Angeles, CA, USA.

Qin Cao (Q)

Departments of Chemistry and Biochemistry and Biological Chemistry, UCLA-DOE Institute, and Molecular Biology Institute, UCLA, Los Angeles, CA, USA.
Howard Hughes Medical Institute, UCLA, Los Angeles, CA, USA.
Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China.

Michael R Sawaya (MR)

Departments of Chemistry and Biochemistry and Biological Chemistry, UCLA-DOE Institute, and Molecular Biology Institute, UCLA, Los Angeles, CA, USA.
Howard Hughes Medical Institute, UCLA, Los Angeles, CA, USA.
ORCID: 0000-0003-0874-9043

Romany Abskharon (R)

Departments of Chemistry and Biochemistry and Biological Chemistry, UCLA-DOE Institute, and Molecular Biology Institute, UCLA, Los Angeles, CA, USA.
Howard Hughes Medical Institute, UCLA, Los Angeles, CA, USA.

Peng Ge (P)

Departments of Chemistry and Biochemistry and Biological Chemistry, UCLA-DOE Institute, and Molecular Biology Institute, UCLA, Los Angeles, CA, USA.
Howard Hughes Medical Institute, UCLA, Los Angeles, CA, USA.
ORCID: 0000-0002-2661-8226

Michael DeTure (M)

Mayo Clinic, Jacksonville, FL, USA.

Dennis W Dickson (DW)

Mayo Clinic, Jacksonville, FL, USA.
ORCID: 0000-0001-7189-7917

Janine Y Fu (JY)

Departments of Chemistry and Biochemistry and Biological Chemistry, UCLA-DOE Institute, and Molecular Biology Institute, UCLA, Los Angeles, CA, USA.
ORCID: 0000-0002-8854-041X

Rachel R Ogorzalek Loo (RR)

Departments of Chemistry and Biochemistry and Biological Chemistry, UCLA-DOE Institute, and Molecular Biology Institute, UCLA, Los Angeles, CA, USA.
ORCID: 0000-0002-0580-2833

Joseph A Loo (JA)

Departments of Chemistry and Biochemistry and Biological Chemistry, UCLA-DOE Institute, and Molecular Biology Institute, UCLA, Los Angeles, CA, USA.
ORCID: 0000-0001-9989-1437

David S Eisenberg (DS)

Departments of Chemistry and Biochemistry and Biological Chemistry, UCLA-DOE Institute, and Molecular Biology Institute, UCLA, Los Angeles, CA, USA. david@mbi.ucla.edu.
Howard Hughes Medical Institute, UCLA, Los Angeles, CA, USA. david@mbi.ucla.edu.
ORCID: 0000-0003-2432-5419

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Amyloïde › Amyloid fibrils in FTLD-TDP are composed of...
questionsmedicales.fr › Techniques d'investigation › Microscopie électronique › Cryomicroscopie électronique › Amyloid fibrils in FTLD-TDP are composed of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › Amyloid fibrils in FTLD-TDP are composed of...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Dégénérescence lobaire frontotemporale › Amyloid fibrils in FTLD-TDP are composed of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Amyloid fibrils in FTLD-TDP are composed of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Amyloid fibrils in FTLD-TDP are composed of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Amyloid fibrils in FTLD-TDP are composed of...