Limited Toxicity of Hypofractionated Intensity Modulated Radiation Therapy for Head and Neck Cancer.

Enteral Nutrition Head and Neck Neoplasms / etiology Humans Radiation Dose Hypofractionation Radiotherapy, Intensity-Modulated / adverse effects Retrospective Studies
Head and neck cancer hypofractionation intensity modulated radiation therapy radiotherapy toxicity

Journal

Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988

Informations de publication

Date de publication:
Apr 2022
Historique:
received: 11 02 2022
revised: 23 02 2022
accepted: 24 02 2022
entrez: 29 3 2022
pubmed: 30 3 2022
medline: 5 4 2022
Statut: ppublish

Résumé

Hypofractionated radiation therapy is not commonly used in head and neck cancers (HNC) due to increased toxicity observed in historical cohorts. This study reviews our institutional experience using hypofractionated intensity modulated radiation therapy (H-IMRT) for HNC. A retrospective cohort study of 56 patients with HNC treated with H-IMRT with ≥50 Gy in 20 fractions was conducted. The primary outcomes were acute and late toxicity. Two-year locoregional control was 87% and median overall survival was 46 months. There were no acute or late grade 4 or 5 toxicities. Acute grade 2 and 3 toxicity was seen in 79% (N=44) and 25% (N=14), respectively. Late grade 2 toxicity was seen in 9% (N=5). No patients required the placement of a feeding tube or tracheostomy. H-IMRT for the definitive or post-operative treatment of HNC using ≥50 Gy in 20 fractions appears safe and well tolerated with modest toxicity.

Sections du résumé

BACKGROUND/AIM OBJECTIVE
Hypofractionated radiation therapy is not commonly used in head and neck cancers (HNC) due to increased toxicity observed in historical cohorts. This study reviews our institutional experience using hypofractionated intensity modulated radiation therapy (H-IMRT) for HNC.
PATIENTS AND METHODS METHODS
A retrospective cohort study of 56 patients with HNC treated with H-IMRT with ≥50 Gy in 20 fractions was conducted. The primary outcomes were acute and late toxicity.
RESULTS RESULTS
Two-year locoregional control was 87% and median overall survival was 46 months. There were no acute or late grade 4 or 5 toxicities. Acute grade 2 and 3 toxicity was seen in 79% (N=44) and 25% (N=14), respectively. Late grade 2 toxicity was seen in 9% (N=5). No patients required the placement of a feeding tube or tracheostomy.
CONCLUSION CONCLUSIONS
H-IMRT for the definitive or post-operative treatment of HNC using ≥50 Gy in 20 fractions appears safe and well tolerated with modest toxicity.

Identifiants

DOI: 10.21873/anticanres.15660 PMID: 35347002
pubmed: 35347002
pii: 42/4/1845
doi: 10.21873/anticanres.15660
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1845-1849

Informations de copyright

Copyright © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Auteurs

Zachary S Mayo (ZS)

Cleveland Clinic Department of Radiation Oncology, Cleveland, OH, U.S.A.

Evelyn O Ilori (EO)

Cleveland Clinic Department of Radiation Oncology, Cleveland, OH, U.S.A.

Brian Matia (B)

Cleveland Clinic Department of Radiation Oncology, Cleveland, OH, U.S.A.

Timothy D Smile (TD)

Cleveland Clinic Department of Radiation Oncology, Cleveland, OH, U.S.A.

Christopher W Fleming (CW)

Cleveland Clinic Department of Radiation Oncology, Cleveland, OH, U.S.A.

Chandana A Reddy (CA)

Cleveland Clinic Department of Radiation Oncology, Cleveland, OH, U.S.A.

Joseph Scharpf (J)

Cleveland Clinic Department of Otolaryngology, Cleveland, OH, U.S.A.

Eric D Lamarre (ED)

Cleveland Clinic Department of Otolaryngology, Cleveland, OH, U.S.A.

Brandon L Prendes (BL)

Cleveland Clinic Department of Otolaryngology, Cleveland, OH, U.S.A.

Jamie Ku (J)

Cleveland Clinic Department of Otolaryngology, Cleveland, OH, U.S.A.

Brian B Burkey (BB)

Cleveland Clinic Department of Otolaryngology, Cleveland, OH, U.S.A.

Nikhil P Joshi (NP)

Rush University Medical Center, Department of Radiation Oncology, Chicago, IL, U.S.A.

Neil M Woody (NM)

Cleveland Clinic Department of Radiation Oncology, Cleveland, OH, U.S.A.

Shlomo A Koyfman (SA)

Cleveland Clinic Department of Radiation Oncology, Cleveland, OH, U.S.A.

Shauna R Campbell (SR)

Cleveland Clinic Department of Radiation Oncology, Cleveland, OH, U.S.A.; campbes6@ccf.org.

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Classifications MeSH

questionsmedicales.fr › Thérapeutique › Thérapie nutritionnelle › Soutien nutritionnel › Nutrition entérale › Limited Toxicity of Hypofractionated Intensity...
questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs de la tête et du cou › Limited Toxicity of Hypofractionated Intensity...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Limited Toxicity of Hypofractionated Intensity...
questionsmedicales.fr › Thérapeutique › Radiothérapie › Dosimétrie en radiothérapie › Fractionnement de la dose d'irradiation › Hypofractionnement de dose › Limited Toxicity of Hypofractionated Intensity...
questionsmedicales.fr › Sciences de l'information › Informatique › Informatique médicale › Applications de l'informatique médicale › Prise de décision assistée par ordinateur › Thérapie assistée par ordinateur › Radiothérapie assistée par ordinateur › Radiothérapie conformationnelle › Radiothérapie conformationnelle avec modulation d'intensité › Limited Toxicity of Hypofractionated Intensity...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Limited Toxicity of Hypofractionated Intensity...