Oxidative Damage Induces a Vacancy G-Quadruplex That Binds Guanine Metabolites: Solution Structure of a cGMP Fill-in Vacancy G-Quadruplex in the Oxidized


Journal

Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056

Informations de publication

Date de publication:
13 04 2022
Historique:
pubmed: 31 3 2022
medline: 15 4 2022
entrez: 30 3 2022
Statut: ppublish

Résumé

Guanine (G)-oxidation to 8-oxo-7,8-dihydroguanine (OG) by reactive oxygen species in genomic DNA has been implicated with various human diseases. G-quadruplex (G4)-forming sequences in gene promoters are highly susceptible to G-oxidation, which can subsequently cause gene activation. However, the underlying G4 structural changes that result from OG modifications remain poorly understood. Herein, we investigate the effect of G-oxidation on the

Identifiants

pubmed: 35352895
doi: 10.1021/jacs.2c00435
pmc: PMC9904417
mid: NIHMS1870059
doi:

Substances chimiques

Guanine 5Z93L87A1R

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

6361-6372

Subventions

Organisme : NCI NIH HHS
ID : P30 CA023168
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA177585
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA240346
Pays : United States

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Auteurs

Kai-Bo Wang (KB)

Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, People's Republic of China.

Yushuang Liu (Y)

Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, People's Republic of China.

Yipu Li (Y)

Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, People's Republic of China.

Jonathan Dickerhoff (J)

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States.

Jinzhu Li (J)

Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, People's Republic of China.

Ming-Hua Yang (MH)

Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, People's Republic of China.

Danzhou Yang (D)

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States.
Purdue Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, United States.
Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
Purdue Institute for Drug Discovery, Purdue University, West Lafayette, Indiana 47907, United States.

Ling-Yi Kong (LY)

Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, People's Republic of China.

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Classifications MeSH