Elevated Serum Triglyceride Levels in Acute Pancreatitis: A Parameter to be Measured and Considered Early.
Journal
World journal of surgery
ISSN: 1432-2323
Titre abrégé: World J Surg
Pays: United States
ID NLM: 7704052
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
accepted:
24
02
2022
pubmed:
1
4
2022
medline:
10
6
2022
entrez:
31
3
2022
Statut:
ppublish
Résumé
The value of serum triglycerides (TGs) related to complications and the severity of acute pancreatitis (AP) has not been clearly defined. Our study aimed to analyze the association of elevated levels of TG with complications and the severity of AP. The demographic and clinical data of patients with AP were prospectively analyzed. TG levels were measured in the first 24 h of admission. Patients were divided into two groups: one with TG values of<200 mg/dL and another with TG≥200 mg/dL. Data on the outcomes of AP were collected. From January 2016 to December 2019, 247 cases were included: 200 with TG<200 mg/dL and 47 with TG≥200 mg/dL. Triglyceride levels≥200 mg/dL were associated with respiratory failure (21.3 vs. 10%, p=0.033), renal failure (23.4 vs. 12%, p=0.044), cardiovascular failure (19.1 vs. 7.5%, p=0.025), organ failure (34 vs. 18.5%, p=0.02), persistent organ failure (27.7 vs. 9.5%, p=0.001), multiple organ failure (19.1 vs. 8%, p=0.031), moderately severe and severe AP (68.1 vs. 40.5%, p=0.001), pancreatic necrosis (63.8 vs. 34%, p<0.001), and admission to the intensive care unit (27.7 vs. 9.5%, p=0.003). In the multivariable analysis, a TG level of≥200 mg/dL was independently associated with respiratory, renal, and cardiovascular failure, organ failure, persistent organ failure, multiple organ failure, pancreatic necrosis, severe pancreatitis, and admission to the intensive care unit (p<0.05). In our cohort, TG≥200 mg/dL was related to local and systemic complications. Early determinations of TG levels in AP could help identify patients at risk of complications.
Sections du résumé
BACKGROUND
The value of serum triglycerides (TGs) related to complications and the severity of acute pancreatitis (AP) has not been clearly defined. Our study aimed to analyze the association of elevated levels of TG with complications and the severity of AP.
METHODS
The demographic and clinical data of patients with AP were prospectively analyzed. TG levels were measured in the first 24 h of admission. Patients were divided into two groups: one with TG values of<200 mg/dL and another with TG≥200 mg/dL. Data on the outcomes of AP were collected.
RESULTS
From January 2016 to December 2019, 247 cases were included: 200 with TG<200 mg/dL and 47 with TG≥200 mg/dL. Triglyceride levels≥200 mg/dL were associated with respiratory failure (21.3 vs. 10%, p=0.033), renal failure (23.4 vs. 12%, p=0.044), cardiovascular failure (19.1 vs. 7.5%, p=0.025), organ failure (34 vs. 18.5%, p=0.02), persistent organ failure (27.7 vs. 9.5%, p=0.001), multiple organ failure (19.1 vs. 8%, p=0.031), moderately severe and severe AP (68.1 vs. 40.5%, p=0.001), pancreatic necrosis (63.8 vs. 34%, p<0.001), and admission to the intensive care unit (27.7 vs. 9.5%, p=0.003). In the multivariable analysis, a TG level of≥200 mg/dL was independently associated with respiratory, renal, and cardiovascular failure, organ failure, persistent organ failure, multiple organ failure, pancreatic necrosis, severe pancreatitis, and admission to the intensive care unit (p<0.05).
CONCLUSIONS
In our cohort, TG≥200 mg/dL was related to local and systemic complications. Early determinations of TG levels in AP could help identify patients at risk of complications.
Identifiants
pubmed: 35355100
doi: 10.1007/s00268-022-06533-w
pii: 10.1007/s00268-022-06533-w
pmc: PMC9174303
doi:
Substances chimiques
Triglycerides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1758-1767Informations de copyright
© 2022. The Author(s).
Références
Endocrinology. 1995 May;136(5):2143-9
pubmed: 7720663
J Dig Dis. 2021 Jan;22(1):41-48
pubmed: 33184988
Ann Epidemiol. 2007 Jul;17(7):491-7
pubmed: 17448682
Clin Chem. 2008 Jan;54(1):131-8
pubmed: 17981921
Eur J Intern Med. 2014 Oct;25(8):689-94
pubmed: 25269432
Med Clin (Barc). 2004 Oct 30;123(15):567-70
pubmed: 15535937
Am J Gastroenterol. 2015 Oct;110(10):1497-503
pubmed: 26323188
J Formos Med Assoc. 2006 Jul;105(7):550-5
pubmed: 16877234
Int J Pancreatol. 1991 Nov-Dec;10(3-4):261-7
pubmed: 1787337
Am J Gastroenterol. 2013 Dec;108(12):1911-7
pubmed: 24126632
Pancreas. 2008 Jul;37(1):13-2
pubmed: 18580438
Gastroenterology. 2013 Jun;144(6):1272-81
pubmed: 23622137
Indian J Endocrinol Metab. 2012 Jul;16(4):671-2
pubmed: 22837949
Lancet. 2000 Jun 3;355(9219):1924-5
pubmed: 10859031
J Clin Gastroenterol. 2009 Jul;43(6):591-6
pubmed: 19034041
Prz Gastroenterol. 2015;10(1):18-22
pubmed: 25960810
Gut. 2013 Jan;62(1):102-11
pubmed: 23100216
Hepatogastroenterology. 2012 Oct;59(119):2318-26
pubmed: 22389298
Crit Care Med. 1995 Oct;23(10):1638-52
pubmed: 7587228
Adv Intern Med. 1969;15:117-54
pubmed: 4908616
World J Gastroenterol. 2010 May 7;16(17):2094-9
pubmed: 20440849
Pancreatology. 2011;11(2):92-8
pubmed: 21577040
World J Gastroenterol. 2008 Jul 28;14(28):4558-61
pubmed: 18680239
Curr Gastroenterol Rep. 2010 Apr;12(2):83-90
pubmed: 20424979
Pancreatology. 2009;9(3):252-7
pubmed: 19407479
Gut. 2018 Apr;67(4):697-706
pubmed: 28774886
BMJ. 2014 Aug 12;349:g4859
pubmed: 25116169
Radiology. 1990 Feb;174(2):331-6
pubmed: 2296641
Am J Gastroenterol. 2013 Sep;108(9):1400-15; 1416
pubmed: 23896955
Pancreatology. 2015 Jul-Aug;15(4):313-20
pubmed: 25800175
AJR Am J Roentgenol. 2004 Nov;183(5):1261-5
pubmed: 15505289
Crit Care Med. 1985 Oct;13(10):818-29
pubmed: 3928249
Expert Rev Gastroenterol Hepatol. 2013 Mar;7(3):193-5
pubmed: 23445227
N Engl J Med. 2016 Nov 17;375(20):1972-1981
pubmed: 27959604
J Gastroenterol Hepatol. 2002 Feb;17 Suppl:S15-39
pubmed: 12000591
Pancreatology. 2018 Jul;18(5):486-493
pubmed: 29802078
Chest. 1992 Jun;101(6):1644-55
pubmed: 1303622
N Engl J Med. 2010 Apr 22;362(16):1491-502
pubmed: 20410514
Arch Endocrinol Metab. 2017 Mar-Apr;61(2):198-201
pubmed: 28225998
JAMA. 2001 May 16;285(19):2486-97
pubmed: 11368702
World J Emerg Surg. 2019 Jun 13;14:27
pubmed: 31210778
BMC Gastroenterol. 2015 Feb 14;15:19
pubmed: 25887309
Pancreatology. 2009;9(6):777-85
pubmed: 20110745
Gastroenterology. 2018 Mar;154(4):1096-1101
pubmed: 29409760
Can J Gastroenterol Hepatol. 2021 Mar 22;2021:6643595
pubmed: 33824864
Dig Dis. 2010;28(2):364-72
pubmed: 20814214
Can J Gastroenterol Hepatol. 2015 Dec 14;:
pubmed: 26668823
Nutrients. 2017 Jul 12;9(7):
pubmed: 28704954
Pancreas. 2014 Nov;43(8):1312-6
pubmed: 25058883
Sci Transl Med. 2011 Nov 2;3(107):107ra110
pubmed: 22049070
J Clin Gastroenterol. 2003 Jan;36(1):54-62
pubmed: 12488710