Bacillus subtilis BR4 derived stigmatellin Y interferes Pqs-PqsR mediated quorum sensing system of Pseudomonas aeruginosa.
Bacillus subtilis
PqsR
biofilm
quorum quenching
quorum sensing
stigmatellin Y
Journal
Journal of basic microbiology
ISSN: 1521-4028
Titre abrégé: J Basic Microbiol
Pays: Germany
ID NLM: 8503885
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
revised:
27
02
2022
received:
12
01
2022
accepted:
13
03
2022
pubmed:
1
4
2022
medline:
7
7
2022
entrez:
31
3
2022
Statut:
ppublish
Résumé
Cell-to-cell communication is essentially required in bacteria for the production of multiple virulence factors and successful colonization in the host. Targeting the virulence factors production without hampering the growth of the pathogens is a potential strategy to control pathogenesis. To accomplish this, a total of 43 mangrove isolates were screened for quorum quenching (QQ) activity against Pseudomonas aeruginosa (PA), in which eight bacteria have shown antibiofilm activity without hampering the growth of the PA. Prominent QQ activity was observed in Bacillus subtilis BR4. Previously, we found that BR4 produces stigmatellin Y, a structural analogue of PQS signal of PA, which could competitively bind with PqsR receptor and inhibits the quorum sensing (QS) system of PA. Further, stigmatellin Y containing ethyl acetate extract (S-EAE) (100 µg ml
Identifiants
pubmed: 35355286
doi: 10.1002/jobm.202200017
doi:
Substances chimiques
Bacterial Proteins
0
Polyenes
0
Virulence Factors
0
stigmatellin
91682-96-1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
801-814Subventions
Organisme : University Grants Commission
ID : 41-1171/2012
Informations de copyright
© 2022 Wiley-VCH GmbH.
Références
Gutiérrez-Gutiérrez B, Salamanca E, de Cueto M, Hsueh PR, Viale P, Paño-Pardo JR, et al. Effect of appropriate combination therapy on mortality of patients with bloodstream infections due to carbapenemase-producing Enterobacteriaceae (INCREMENT): a retrospective cohort study. Lancet Infect Dis. 2017;17:726-34.
Wang S, Payne GF, Bentley WE. Quorum sensing communication: molecularly connecting cells, their neighbors, and even devices. Annu Rev Chem Biomol Eng. 2020;11:447-68.
Boopathi S, Liu D, Jia AQJ. Molecular trafficking between bacteria determines the shape of gut microbial community. Gut Microbes. 2021;13:1959841.
Rossi E, La Rosa R, Bartell JA, Marvig RL, Haagensen J, Sommer LM, et al. Pseudomonas aeruginosa adaptation and evolution in patients with cystic fibrosis. Nat Rev Microbiol. 2021;19:331-42.
Gangcuangco LM, Clark P, Stewart C, Miljkovic G, Saul ZK. Persistent bacteremia from Pseudomonas aeruginosa with in vitro resistance to the novel antibiotics ceftolozane-tazobactam and ceftazidime-avibactam. Case Rep Infect Dis. 2016;2016:1520404.
Carradori S, di Giacomo N, Lobefalo M, Luisi G, Campestre C, Sisto F. Biofilm and quorum sensing inhibitors: the road so far. Expert Opin Ther Pat. 2020;30:917-30.
Reuter K, Steinbach A, Helms V. Interfering with bacterial quorum sensing. Perspect Medicin Chem. 2016;8:1-15.
Newman DJ, Cragg GM. Natural products as sources of new drugs from 1981 to 2014. J Nat Prod. 2016;79:629-61.
Srinivasan R, Kannappan A, Shi C, Lin XJMD. Marine bacterial secondary metabolites: a treasure house for structurally unique and effective antimicrobial compounds. Mar Drugs. 2021;19:530.
Boopathi S, Selvakumar G, Sivakumar N. Quorum quenching potentials of probiotic Enterococcus durans LAB38 against methicillin resistant Staphylococcus aureus. Asian J Pharm Clin Res. 2017;10:445-50.
Bassler BL, Greenberg EP, Stevens AMJ. Cross-species induction of luminescence in the quorum-sensing bacterium Vibrio harveyi. J Bacteriol. 1997;179:4043-5.
Musthafa KS, Saroja V, Pandian SK, Ravi AV. Antipathogenic potential of marine Bacillus sp. SS4 on N-acyl-homoserine-lactone-mediated virulence factors production in Pseudomonas aeruginosa (PAO1). J Biosci. 2011;36:55-67.
Essar DW, Eberly L, Hadero A, Crawford I. Identification and characterization of genes for a second anthranilate synthase in Pseudomonas aeruginosa: interchangeability of the two anthranilate synthases and evolutionary implications. J Bacteriol. 1990;172:884-900.
Ortori CA, Dubern JF, Chhabra SR, Cámara M, Hardie K, Williams P, et al. Simultaneous quantitative profiling of N-acyl-L-homoserine lactone and 2-alkyl-4 (1 H)-quinolone families of quorum-sensing signaling molecules using LC-MS/MS. Anal Bioanal Chem. 2011;399:839-50.
Boopathi S, Vashisth R, Manoharan P, Kandasamy R, Sivakumar N, Stigmatellin Y. An anti-biofilm compound from Bacillus subtilis BR4 possibly interferes in PQS-PqsR mediated quorum sensing system in Pseudomonas aeruginosa. Bioorg Med Chem Lett. 2017;27:2113-8.
Déziel E, Lépine F, Milot S, He J, Mindrinos MN, Tompkins RG, et al. Analysis of Pseudomonas aeruginosa 4-hydroxy-2-alkylquinolines (HAQs) reveals a role for 4-hydroxy-2-heptylquinoline in cell-to-cell communication. Proc Natl Acad Sci USA. 2004;101:1339-44.
Romero M, Martin-Cuadrado AB, Otero A. Determination of whether quorum quenching is a common activity in marine bacteria by analysis of cultivable bacteria and metagenomic sequences. Appl Environ Microbiol. 2012;78:6345-8.
Kaur N, Rajendran MK, Kaur G, Shanmugam M. Isoptericola rhizophila sp. nov., a novel actinobacterium isolated from rhizosphere soil. Antonie Van Leeuwenhoek. 2014;106:301-7.
Rameshkumar N, Nair S. Isolation and molecular characterization of genetically diverse antagonistic, diazotrophic red-pigmented vibrios from different mangrove rhizospheres. FEMS Microbiol Ecol. 2009;67:455-67.
Yateem A, Al-Sharrah T. Enhanced hydrocarbons degradation in the rhizosphere of mangrove plants by a halophilic Bacillus subtilis subtilis strain. Soil Sediment Contam. 2011;20:261-73.
Alfaro-Espinoza G, Ullrich MS. Marinobacterium mangrovicola sp. nov., a marine nitrogen-fixing bacterium isolated from mangrove roots of Rhizophora mangle. Int J Syst Evol Microbiol. 2014;64:3988-93.
Shahnawaz M, Sangale MK, Ade AB. Rhizosphere of Avicennia marina (Forsk.) Vierh. as a landmark for polythene degrading bacteria. Environ Sci Pollut Res Int. 2016;23:14621-35.
Liu M, Cui Y, Chen Y, Lin X, Huang H, Bao S. Diversity of Bacillus-like bacterial community in the sediments of the Bamenwan mangrove wetland in Hainan, China. Can J Microbiol. 2017;63:238-45.
Galdino ACM, Viganor L, Ziccardi M, Nunes APF, dos Santos KRN, Branquinha MH, et al. Heterogeneous production of proteases from Brazilian clinical isolates of Pseudomonas aeruginosa. Enferm Infect Microbiol Clin. 2017;35:630-7.
Cowell BA, Twining SS, Hobden JA, Kwong MSF, Fleiszig SMJ. Mutation of lasA and lasB reduces Pseudomonas aeruginosa invasion of epithelial cells. Microbiology. 2003;149:2291-9.
Allen L, Dockrell DH, Pattery T, Lee DG, Cornelis P, Hellewell PG, et al. Pyocyanin production by Pseudomonas aeruginosa induces neutrophil apoptosis and impairs neutrophil-mediated host defenses in vivo. J Immunol. 2005;174:3643-9.
Chen F, Gao Y, Chen X, Yu Z, Li XJ. Quorum quenching enzymes and their application in degrading signal molecules to block quorum sensing-dependent infection. Int J Mol Sci. 2013;14:17477-500.
Maura D, Hazan R, Kitao T, Ballok AE, Rahme LG. Evidence for direct control of virulence and defense gene circuits by the Pseudomonas aeruginosa quorum sensing regulator, MvfR. Sci Rep. 2016;6:34083.
Wade DS, Calfee MW, Rocha ER, Ling EA, Engstrom E, Coleman JP, et al. Regulation of Pseudomonas quinolone signal synthesis in Pseudomonas aeruginosa. J Bacteriol. 2005;187:4372-80.
Royt PW, Honeychuck RV, Ravich V, Ponnaluri P, Pannell LK, Buyer JS, et al. 4-Hydroxy-2-nonylquinoline: a novel iron chelator isolated from a bacterial cell membrane. Bioorg Chem. 2001;29:387-97.
Ilangovan A, Fletcher M, Rampioni G, Pustelny C, Rumbaugh K, Heeb S, et al. Structural basis for native agonist and synthetic inhibitor recognition by the Pseudomonas aeruginosa quorum sensing regulator PqsR (MvfR). PLOS Pathog. 2013;9:e1003508.
Ramasubburayan R, Prakash S, Iyapparaj P, Sumathi S, Titus S, Immanuel G, et al. Isolation, screening and evaluation of antifouling activity of mangrove associated bacterium, Bacillus subtilis subsp. subtilis RG. Proc Nat Acad Sci India B: Biol Sci. 2015;87:1015-24.