Processing of information from the parafascicular nucleus of the thalamus through the basal ganglia.
substantia nigra pars reticulata
RRID:AB_10000240
RRID:AB_162543
RRID:AB_2209751
RRID:AB_2301751
RRID:AB_2337244
RRID:AB_2340375
RRID:AB_2535718
RRID:IMSR_EM:01153
RRID:IMSR_JAX:012569
basal ganglia
in vivo electrophysiology
intralaminar nuclei of the thalamus
optogenetics
Journal
Journal of neuroscience research
ISSN: 1097-4547
Titre abrégé: J Neurosci Res
Pays: United States
ID NLM: 7600111
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
revised:
08
03
2022
received:
13
08
2021
accepted:
15
03
2022
pubmed:
1
4
2022
medline:
23
4
2022
entrez:
31
3
2022
Statut:
ppublish
Résumé
Accumulating evidence implicates the parafascicular nucleus of the thalamus (Pf) in basal ganglia (BG)-related functions and pathologies. Despite Pf connectivity with all BG components, most attention is focused on the thalamostriatal system and an integrated view of thalamic information processing in this network is still lacking. Here, we addressed this question by recording the responses elicited by Pf activation in single neurons of the substantia nigra pars reticulata (SNr), the main BG output structure in rodents, in anesthetized mice. We performed optogenetic activation of Pf neurons innervating the striatum, the subthalamic nucleus (STN), or the SNr using virally mediated transcellular delivery of Cre from injection in either target in Rosa26-LoxP-stop-ChR2-EYFP mice to drive channelrhodopsin expression. Photoactivation of Pf neurons connecting the striatum evoked an inhibition often followed by an excitation, likely resulting from the activation of the trans-striatal direct and indirect pathways, respectively. Photoactivation of Pf neurons connecting the SNr or the STN triggered one or two early excitations, suggesting partial functional overlap of trans-subthalamic and direct thalamonigral projections. Excitations were followed in about half of the cases by an inhibition that might reflect recruitment of intranigral inhibitory loops. Finally, global Pf stimulation, electrical or optogenetic, elicited similar complex responses comprising up to four components: one or two short-latency excitations, an inhibition, and a late excitation. These data provide evidence for functional connections between the Pf and different BG components and for convergence of the information processed through these pathways in single SNr neurons, stressing their importance in regulating BG outflow.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1370-1385Informations de copyright
© 2022 Wiley Periodicals LLC.
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