Helminthic dehydrogenase drives PGE
Prostaglandin E2
Taenia solium cyst
Treg cells
glutamate dehydrogenase
immune regulation
Journal
EMBO reports
ISSN: 1469-3178
Titre abrégé: EMBO Rep
Pays: England
ID NLM: 100963049
Informations de publication
Date de publication:
04 05 2022
04 05 2022
Historique:
revised:
02
03
2022
received:
04
10
2021
accepted:
14
03
2022
pubmed:
1
4
2022
medline:
6
5
2022
entrez:
31
3
2022
Statut:
ppublish
Résumé
Immunoregulation of inflammatory, infection-triggered processes in the brain constitutes a central mechanism to control devastating disease manifestations such as epilepsy. Observational studies implicate the viability of Taenia solium cysts as key factor determining severity of neurocysticercosis (NCC), the most common cause of epilepsy, especially in children, in Sub-Saharan Africa. Viable, in contrast to decaying, cysts mostly remain clinically silent by yet unknown mechanisms, potentially involving Tregs in controlling inflammation. Here, we show that glutamate dehydrogenase from viable cysts instructs tolerogenic monocytes to release IL-10 and the lipid mediator PGE
Identifiants
pubmed: 35357743
doi: 10.15252/embr.202154096
pmc: PMC9066053
doi:
Substances chimiques
Interleukin-10
130068-27-8
Oxidoreductases
EC 1.-
Dinoprostone
K7Q1JQR04M
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e54096Informations de copyright
© 2022 The Authors. Published under the terms of the CC BY NC ND 4.0 license.
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