O-GlcNAcase Inhibitor ASN90 is a Multimodal Drug Candidate for Tau and α-Synuclein Proteinopathies.
Alzheimer’s disease
O-GlcNAcase inhibitor
Parkinson’s disease
drug development
microtubule-associated protein tau
proteinopathies
α-synuclein
Journal
ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337
Informations de publication
Date de publication:
20 04 2022
20 04 2022
Historique:
pubmed:
1
4
2022
medline:
22
4
2022
entrez:
31
3
2022
Statut:
ppublish
Résumé
Neurodegenerative proteinopathies are characterized by the intracellular formation of insoluble and toxic protein aggregates in the brain that are closely linked to disease progression. In Alzheimer's disease and in rare tauopathies, aggregation of the microtubule-associated tau protein leads to the formation of neurofibrillary tangles (NFT). In Parkinson's disease (PD) and other α-synucleinopathies, intracellular Lewy bodies containing aggregates of α-synuclein constitute the pathological hallmark. Inhibition of the glycoside hydrolase O-GlcNAcase (OGA) prevents the removal of O-linked
Identifiants
pubmed: 35357812
doi: 10.1021/acschemneuro.2c00057
pmc: PMC9026285
doi:
Substances chimiques
Pharmaceutical Preparations
0
alpha-Synuclein
0
tau Proteins
0
hexosaminidase C
EC 3.2.1.50
beta-N-Acetylhexosaminidases
EC 3.2.1.52
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1296-1314Références
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