Associations between high-metabolic rate organ masses and fasting hunger: A study using whole-body magnetic resonance imaging in healthy males.
Appetite
Energy expenditure
Fasting hunger
Fat-free mass
High-metabolic rate organs
Liver
Journal
Physiology & behavior
ISSN: 1873-507X
Titre abrégé: Physiol Behav
Pays: United States
ID NLM: 0151504
Informations de publication
Date de publication:
01 06 2022
01 06 2022
Historique:
received:
31
10
2021
revised:
11
03
2022
accepted:
25
03
2022
pubmed:
1
4
2022
medline:
20
4
2022
entrez:
31
3
2022
Statut:
ppublish
Résumé
Fat-free mass (FFM) has been shown to be positively associated with hunger and energy intake, an association mediated by resting metabolic rate (RMR). However, FFM comprises a heterogeneous group of tissues with distinct metabolic rates, and it remains unknown how specific high-metabolic rate organs contribute to the degree of perceived hunger. To examine whether FFM and its anatomical components were associated with fasting hunger when assessed at the tissue-organ level. Body composition (quantitative magnetic resonance and magnetic resonance imaging), RMR and whole-body glucose oxidation (indirect calorimetry), HOMA-index as a marker of insulin sensitivity, nitrogen balance and fasting hunger (visual analogue scales) were assessed in 21 healthy males (age = 25 ± 3y; BMI = 23.4 ± 2.1 kg/m FFM (r Fasting hunger was more strongly associated with the combined mass of high-metabolic rate organs than with FFM as a uniform body component, highlighting the importance of integrating individual tissue-organ masses and their functional correlates into homeostatic models of human appetite. The association between liver mass and fasting hunger may reflect its role in ensuring the brain's basal energy needs are met.
Sections du résumé
BACKGROUND
Fat-free mass (FFM) has been shown to be positively associated with hunger and energy intake, an association mediated by resting metabolic rate (RMR). However, FFM comprises a heterogeneous group of tissues with distinct metabolic rates, and it remains unknown how specific high-metabolic rate organs contribute to the degree of perceived hunger.
OBJECTIVE
To examine whether FFM and its anatomical components were associated with fasting hunger when assessed at the tissue-organ level.
DESIGN
Body composition (quantitative magnetic resonance and magnetic resonance imaging), RMR and whole-body glucose oxidation (indirect calorimetry), HOMA-index as a marker of insulin sensitivity, nitrogen balance and fasting hunger (visual analogue scales) were assessed in 21 healthy males (age = 25 ± 3y; BMI = 23.4 ± 2.1 kg/m
RESULTS
FFM (r
CONCLUSIONS
Fasting hunger was more strongly associated with the combined mass of high-metabolic rate organs than with FFM as a uniform body component, highlighting the importance of integrating individual tissue-organ masses and their functional correlates into homeostatic models of human appetite. The association between liver mass and fasting hunger may reflect its role in ensuring the brain's basal energy needs are met.
Identifiants
pubmed: 35358549
pii: S0031-9384(22)00103-2
doi: 10.1016/j.physbeh.2022.113796
pii:
doi:
Substances chimiques
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
113796Subventions
Organisme : Wellcome Trust
ID : 204825/Z/16/Z
Pays : United Kingdom
Informations de copyright
Copyright © 2022. Published by Elsevier Inc.