Correlates of non-persistent endocrine disrupting chemical mixtures among reproductive-aged Black women in Detroit, Michigan.
Black women
Chemical mixtures
Endocrine disruptors
Parabens
Phenols
Phthalates
Journal
Chemosphere
ISSN: 1879-1298
Titre abrégé: Chemosphere
Pays: England
ID NLM: 0320657
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
received:
04
01
2022
revised:
14
03
2022
accepted:
24
03
2022
pubmed:
1
4
2022
medline:
25
5
2022
entrez:
31
3
2022
Statut:
ppublish
Résumé
Some studies indicate that Black women have higher exposure to multiple non-persistent endocrine disrupting chemicals (EDCs) than white women, but little is known about correlates of exposure to EDC mixtures. Using baseline data from a prospective cohort study of reproductive-aged Black women (N = 751), we characterized profiles of EDC mixtures and identified correlates of exposure. At baseline, we quantified biomarkers of 16 phthalates, 7 phenols, 4 parabens, and triclocarban in urine and collected covariate data through self-administered questionnaires and interviews. We used principal component (PC) analysis and k-means clustering to describe EDC mixture profiles. Associations between correlates and PCs were estimated as the mean difference (β) in PC scores, while associations between correlates and cluster membership were estimated as the odds ratio (OR) of cluster membership. Personal care product use was consistently associated with profiles of higher biomarker concentrations of non-persistent EDCs. Use of nail polish, menstrual and vaginal products (e.g., vaginal powder, vaginal deodorant), and sunscreen was associated with a mixture of phthalate and some phenol biomarkers using both methods. Current vaginal ring use, a form of hormonal contraception placed inside the vagina, was strongly associated with higher concentrations of high molecular weight phthalate biomarkers (k-means clustering: OR = 2.42, 95% CI = 1.28, 4.59; PCA: β = -0.32, 95% CI = -0.71, 0.07). Several dietary, reproductive, and demographic correlates were also associated with mixtures of EDC biomarkers. These findings suggest that personal care product use, diet, and contraceptive use may be sources of exposure to multiple non-persistent EDCs among reproductive-aged Black women. Targeted interventions to reduce exposure to multiple EDCs among Black women are warranted.
Identifiants
pubmed: 35358566
pii: S0045-6535(22)00940-7
doi: 10.1016/j.chemosphere.2022.134447
pmc: PMC9215202
mid: NIHMS1795076
pii:
doi:
Substances chimiques
Biomarkers
0
Endocrine Disruptors
0
Environmental Pollutants
0
Phenols
0
Phthalic Acids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
134447Subventions
Organisme : NIEHS NIH HHS
ID : R01 ES024749
Pays : United States
Organisme : NIEHS NIH HHS
ID : T32 ES014562
Pays : United States
Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.
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