Boosting the therapeutic efficacy of discoidal nanoconstructs against glioblastoma with rationally designed PEG-Docetaxel conjugates.

Animals Antineoplastic Agents Docetaxel Glioblastoma / drug therapy Mice Nanoparticles / chemistry Oleic Acid Polyethylene Glycols / chemistry Taxoids / pharmacology
Docetaxel Drug conjugates Drug delivery Glioblastoma Nanomedicine

Journal

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
ISSN: 1873-3441
Titre abrégé: Eur J Pharm Biopharm
Pays: Netherlands
ID NLM: 9109778

Informations de publication

Date de publication:
May 2022
Historique:
received: 15 11 2021
revised: 18 03 2022
accepted: 22 03 2022
pubmed: 1 4 2022
medline: 4 5 2022
entrez: 31 3 2022
Statut: ppublish

Résumé

Maximizing loading while modulating the release of therapeutic molecules from nanoparticles and implantable drug delivery systems is the key to successfully address deadly diseases like brain cancer. Here, four different conjugates of the potent chemotherapeutic molecule docetaxel (DTXL)were realized to optimize the pharmacological properties of 1,000 × 400 nmDiscoidal PolymericNanoconstructs(DPNs). DTXL was covalently linked to poly-(ethylene) glycol(PEG)chains of different molecular weights, namely 350, 550 and 1,000 Da, and oleic acid (OA). After extensive physico-chemical and pharmacological characterizations, the conjugate PEG

Identifiants

DOI: 10.1016/j.ejpb.2022.03.011 PMID: 35358697
pubmed: 35358697
pii: S0939-6411(22)00059-5
doi: 10.1016/j.ejpb.2022.03.011
pii:
doi:

Substances chimiques

Antineoplastic Agents 0
Taxoids 0
Docetaxel 15H5577CQD
Oleic Acid 2UMI9U37CP
Polyethylene Glycols 3WJQ0SDW1A

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

90-100

Informations de copyright

Copyright © 2022 Elsevier B.V. All rights reserved.

Auteurs

Alessia Felici (A)

Laboratory of Nanotechnology for Precision Medicine, Fondazione Istituto Italiano di Tecnologia, Genoa 16163, Italy; Department of Informatics, Bioengineering, Robotics and System Engineering, University of Genoa, Genoa, Italy.

Michele Schlich (M)

Laboratory of Nanotechnology for Precision Medicine, Fondazione Istituto Italiano di Tecnologia, Genoa 16163, Italy; Department of Life and Environmental Sciences, Università degli Studi di Cagliari, 09124 Cagliari, Italy.

Daniele Di Mascolo (D)

Laboratory of Nanotechnology for Precision Medicine, Fondazione Istituto Italiano di Tecnologia, Genoa 16163, Italy.

Luca Goldoni (L)

Analytical Chemistry Laboratory, Fondazione Istituto Italiano di Tecnologia, 16163 Genova, Italy.

Anna Lisa Palange (A)

Laboratory of Nanotechnology for Precision Medicine, Fondazione Istituto Italiano di Tecnologia, Genoa 16163, Italy.

Paolo Decuzzi (P)

Laboratory of Nanotechnology for Precision Medicine, Fondazione Istituto Italiano di Tecnologia, Genoa 16163, Italy. Electronic address: paolo.decuzzi@iit.it.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Boosting the therapeutic efficacy of discoidal...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Boosting the therapeutic efficacy of discoidal...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Diterpènes › Taxoïdes › Docetaxel › Boosting the therapeutic efficacy of discoidal...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Gliome › Astrocytome › Glioblastome › Boosting the therapeutic efficacy of discoidal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Boosting the therapeutic efficacy of discoidal...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Boosting the therapeutic efficacy of discoidal...
questionsmedicales.fr › Lipides › Acides gras › Acides gras insaturés › Acides gras monoinsaturés › Acides oléiques › Acide oléique › Boosting the therapeutic efficacy of discoidal...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Polyéthylène glycols › Boosting the therapeutic efficacy of discoidal...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Diterpènes › Taxoïdes › Boosting the therapeutic efficacy of discoidal...