Autoantibodies Against Proteins Previously Associated With Autoimmunity in Adult and Pediatric Patients With COVID-19 and Children With MIS-C.

The antibody profile against autoantigens previously associated with autoimmune diseases and other human proteins in patients with COVID-19 or multisystem inflammatory syndrome in children (MIS-C) remains poorly defined. Here we show that 30% of adults with COVID-19 had autoantibodies against the lung antigen KCNRG, and 34% had antibodies to the SLE-associated Smith-D3 protein. Children with COVID-19 rarely had autoantibodies; one of 59 children had GAD65 autoantibodies associated with acute onset of insulin-dependent diabetes. While autoantibodies associated with SLE/Sjögren's syndrome (Ro52, Ro60, and La) and/or autoimmune gastritis (gastric ATPase) were detected in 74% (40/54) of MIS-C patients, further analysis of these patients and of children with Kawasaki disease (KD), showed that the administration of intravenous immunoglobulin (IVIG) was largely responsible for detection of these autoantibodies in both groups of patients. Monitoring

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Copyright © 2022 Burbelo, Castagnoli, Shimizu, Delmonte, Dobbs, Discepolo, Lo Vecchio, Guarino, Licciardi, Ramenghi, Rey-Jurado, Vial, Marseglia, Licari, Montagna, Rossi, Montealegre Sanchez, Barron, Warner, Chiorini, Espinosa, Noguera, Dropulic, Truong, Gerstbacher, Mató, Kanegaye, Tremoulet, Pediatric Emergency Medicine Kawasaki Group, Eisenstein, Su, Imberti, Poli, Burns, Notarangelo and Cohen.

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The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.