Role of adherent and invasive
BACTERIAL INTERACTIONS
BACTERIAL PATHOGENESIS
CROHN'S DISEASE
E. COLI
Journal
Gut
ISSN: 1468-3288
Titre abrégé: Gut
Pays: England
ID NLM: 2985108R
Informations de publication
Date de publication:
01 2023
01 2023
Historique:
received:
24
08
2021
accepted:
10
03
2022
pubmed:
2
4
2022
medline:
4
1
2023
entrez:
1
4
2022
Statut:
ppublish
Résumé
We used the postoperative recurrence model to better understand the role of adherent and invasive From a prospective, multicentre cohort of operated patients with CD, AIEC identification was performed within the surgical specimen (M0) (N=181 patients) and the neoterminal ileum (n=119 patients/181) during colonoscopy performed 6 months after surgery (M6). Endoscopic postoperative recurrence was graded using Rutgeerts' index. The mucosa-associated microbiota was analysed by 16S sequencing at M0 and M6. Relative risks or ORs were adjusted on potential confounders. AIEC prevalence was twofold higher within the neoterminal ileum at M6 (30.3%) than within the surgical specimen (14.9%) (p<0.001). AIEC within the neoterminal ileum at M6 was associated with higher rate of early ileal lesions (i1) (41.6% vs 17.1%; aRR 3.49 (95% CI 1.01 to 12.04), p=0.048) or ileal lesions (i2b+i3) (38.2% vs 17.1%; aRR 3.45 (95% CI 1.06 to 11.30), p=0.040) compared with no lesion (i0). AIEC within the surgical specimen was predictive of higher risk of i2b-endoscopic postoperative recurrence (POR) (aOR 2.54 (95% CI 1.01 to 6.44), p=0.049) and severe endoscopic POR (aOR 3.36 (95% CI 1.25 to 9.06), p=0.017). While only 5.0% (6/119) of the patients were AIEC-positive at both M0 and M6, 43.7% (52/119), patients with history of positive test for AIEC (M0 or M6) had higher risk of ileal endoscopic POR (aOR 2.32 (95% CI 1.01 to 5.39), p=0.048)), i2b-endoscopic postoperative recurrence (aOR 2.41 (95% CI 1.01 to 5.74); p=0.048) and severe endoscopic postoperative (aOR=3.84 (95% CI 1.32 to 11.18), p=0.013). AIEC colonisation was associated with a specific microbiota signature including increased abundance of Based on the postoperative recurrence model, our data support the idea that AIEC are involved in the early steps of ileal CD. NCT03458195.
Identifiants
pubmed: 35361684
pii: gutjnl-2021-325971
doi: 10.1136/gutjnl-2021-325971
doi:
Banques de données
ClinicalTrials.gov
['NCT03458195']
Types de publication
Clinical Trial
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
39-48Investigateurs
Pierre Cattan Saint-Louis
(PC)
Mircea Chirica
(M)
Nicolas Munoz-Bongrand
(N)
Hélène Corte
(H)
Jean-Marc Gornet
(JM)
Clotilde Baudry
(C)
Nelson Lourenco
(N)
Mariane Maillet
(M)
My-Linh Tran-Minh
(ML)
Andrée Nisard
(A)
Laurent Beaugerie Saint-Antoine
(LB)
Anne Bourrier
(A)
Isabelle Nion-Larmurier
(I)
Cecilia Landman
(C)
Julien Kirchgesner
(J)
Xavier Dray
(X)
Ulrika Chaput
(U)
Marine Camus
(M)
Philippe Marteau
(P)
Loic Brot
(L)
Najim Chafai
(N)
Jeremie H Lefevre
(JH)
Clotilde Debove
(C)
Yann Parc
(Y)
Magali Svreck
(M)
Nadia Hoyau-Idrissi
(N)
Nathalie Guedj
(N)
Yves Panis
(Y)
Leon Maggiorri
(L)
Mariane Ferron
(M)
Yoram Bouhnik
(Y)
Olivier Corcos
(O)
Gilles Bommelaer
(G)
Marion Goutte
(M)
Anne Dubois
(A)
Caroline Chevarin
(C)
Marie Dodel
(M)
Dilek Coban
(D)
Pierre Desreumaux
(P)
Philippe Zerbib
(P)
Coralie Sommeville
(C)
Virginie Suffys
(V)
Jean-Louis Dupas
(JL)
Franck Brazier
(F)
Clara Yzet
(C)
Denis Chatelain
(D)
Christophe Attencourt
(C)
Charles Sabbagh
(C)
Martine Leconte
(M)
Bernard Flourié
(B)
Yves François
(Y)
Eddy Cotte
(E)
Anne-Laure Charlois
(AL)
Peggy Falgon
(P)
Driffa Moussata
(D)
Marion Chauvenet
(M)
Sarah Boyer
(S)
Jérome Filippi
(J)
Paul Hofmann
(P)
Carole Margalef
(C)
Patricia Detre
(P)
Commentaires et corrections
Type : CommentIn
Informations de copyright
© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.