Microbiota-dependent activation of the myeloid calcineurin-NFAT pathway inhibits B7H3- and B7H4-dependent anti-tumor immunity in colorectal cancer.

Animals B7 Antigens CD8-Positive T-Lymphocytes Calcineurin / metabolism Colorectal Neoplasms / metabolism Mice Microbiota NFATC Transcription Factors / metabolism V-Set Domain-Containing T-Cell Activation Inhibitor 1
B7H3 B7H4 CD276 NFAT VCTN1 calcineurin colorectal cancer microbiota

Journal

Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918

Informations de publication

Date de publication:
12 04 2022
Historique:
received: 16 12 2021
revised: 10 03 2022
accepted: 11 03 2022
pubmed: 2 4 2022
medline: 16 4 2022
entrez: 1 4 2022
Statut: ppublish

Résumé

Bacterial sensing by intestinal tumor cells contributes to tumor growth through cell-intrinsic activation of the calcineurin-NFAT axis, but the role of this pathway in other intestinal cells remains unclear. Here, we found that myeloid-specific deletion of calcineurin in mice activated protective CD8

Identifiants

DOI: 10.1016/j.immuni.2022.03.008 PMID: 35364006
pubmed: 35364006
pii: S1074-7613(22)00131-5
doi: 10.1016/j.immuni.2022.03.008
pii:
doi:

Substances chimiques

B7 Antigens 0
CD276 protein, human 0
Cd276 protein, mouse 0
NFATC Transcription Factors 0
V-Set Domain-Containing T-Cell Activation Inhibitor 1 0
Calcineurin EC 3.1.3.16

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

701-717.e7

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests G.Z. is a named inventor on a patent (EP2955232A1: Method for diagnosing adenomas and/or colorectal cancer (CRC) based on analyzing the gut microbiome).

Auteurs

Kenneth Peuker (K)

Department of Medicine I, University Medical Center Dresden, Technische Universität (TU) Dresden, 01307 Dresden, Germany; Center for Regenerative Therapies Dresden (CRTD), Technische Universität (TU) Dresden, 01307 Dresden, Germany.

Anne Strigli (A)

Department of Medicine I, University Medical Center Dresden, Technische Universität (TU) Dresden, 01307 Dresden, Germany; Center for Regenerative Therapies Dresden (CRTD), Technische Universität (TU) Dresden, 01307 Dresden, Germany.

Daniele V F Tauriello (DVF)

Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri i Reixac 10, 08028 Barcelona, Spain; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), 08028 Barcelona, Spain.

Alexander Hendricks (A)

Department of General and Thoracic Surgery, University Medical Center Schleswig-Holstein, 24105 Kiel, Germany; Department of General Surgery, University Medicine Rostock, 18507 Rostock, Germany.

Witigo von Schönfels (W)

Department of General and Thoracic Surgery, University Medical Center Schleswig-Holstein, 24105 Kiel, Germany.

Greta Burmeister (G)

Department of General and Thoracic Surgery, University Medical Center Schleswig-Holstein, 24105 Kiel, Germany; Department of General Surgery, University Medicine Rostock, 18507 Rostock, Germany.

Mario Brosch (M)

Department of Medicine I, University Medical Center Dresden, Technische Universität (TU) Dresden, 01307 Dresden, Germany; Center for Regenerative Therapies Dresden (CRTD), Technische Universität (TU) Dresden, 01307 Dresden, Germany.

Alexander Herrmann (A)

Department of Medicine I, University Medical Center Dresden, Technische Universität (TU) Dresden, 01307 Dresden, Germany; Center for Regenerative Therapies Dresden (CRTD), Technische Universität (TU) Dresden, 01307 Dresden, Germany.

Sandra Krüger (S)

Institute of Pathology, University Medical Center Schleswig-Holstein, 24105 Kiel, Germany.

Jessica Nitsche (J)

Department of Medicine I, University Medical Center Dresden, Technische Universität (TU) Dresden, 01307 Dresden, Germany; Center for Regenerative Therapies Dresden (CRTD), Technische Universität (TU) Dresden, 01307 Dresden, Germany.

Lea Južnić (L)

Department of Medicine I, University Medical Center Dresden, Technische Universität (TU) Dresden, 01307 Dresden, Germany; Center for Regenerative Therapies Dresden (CRTD), Technische Universität (TU) Dresden, 01307 Dresden, Germany.

Marc Marius Geissler (MM)

Department of Medicine I, University Medical Center Dresden, Technische Universität (TU) Dresden, 01307 Dresden, Germany; Center for Regenerative Therapies Dresden (CRTD), Technische Universität (TU) Dresden, 01307 Dresden, Germany.

Andreas Hiergeist (A)

Institute of Clinical Microbiology and Hygiene, University Hospital Regensburg, 93042 Regensburg, Germany.

André Gessner (A)

Institute of Clinical Microbiology and Hygiene, University Hospital Regensburg, 93042 Regensburg, Germany.

Jakob Wirbel (J)

Structural and Computational Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.

Ruby Priyadarshini Ponnudurai (RP)

Structural and Computational Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.

Antje Tunger (A)

Institute of Immunology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany; National Center for Tumor Diseases (NCT), Partner Site Dresden, 01307 Dresden, Germany.

Rebekka Wehner (R)

Institute of Immunology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany; National Center for Tumor Diseases (NCT), Partner Site Dresden, 01307 Dresden, Germany.

Daniel E Stange (DE)

National Center for Tumor Diseases (NCT), Partner Site Dresden, 01307 Dresden, Germany; Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, 01307 Dresden, Germany; German Cancer Consortium (DKTK), Partner Site Dresden, Dresden, Germany; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

Jürgen Weitz (J)

National Center for Tumor Diseases (NCT), Partner Site Dresden, 01307 Dresden, Germany; Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, 01307 Dresden, Germany; German Cancer Consortium (DKTK), Partner Site Dresden, Dresden, Germany; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

Daniela E Aust (DE)

Institute of Pathology, University Medical Center Dresden, Technische Universität (TU) Dresden, Dresden, Germany; Tumor and Normal Tissue Bank of the University Cancer Center (UCC), University Medical Center Dresden, Technische Universität (TU) Dresden, Dresden, Germany.

Gustavo B Baretton (GB)

Institute of Pathology, University Medical Center Dresden, Technische Universität (TU) Dresden, Dresden, Germany.

Marc Schmitz (M)

Institute of Immunology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany; National Center for Tumor Diseases (NCT), Partner Site Dresden, 01307 Dresden, Germany; German Cancer Consortium (DKTK), Partner Site Dresden, Dresden, Germany; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

Christoph Röcken (C)

Institute of Pathology, University Medical Center Schleswig-Holstein, 24105 Kiel, Germany.

Jochen Hampe (J)

Department of Medicine I, University Medical Center Dresden, Technische Universität (TU) Dresden, 01307 Dresden, Germany; Center for Regenerative Therapies Dresden (CRTD), Technische Universität (TU) Dresden, 01307 Dresden, Germany.

Sebastian Hinz (S)

Department of General and Thoracic Surgery, University Medical Center Schleswig-Holstein, 24105 Kiel, Germany; Department of General Surgery, University Medicine Rostock, 18507 Rostock, Germany.

Georg Zeller (G)

Structural and Computational Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.

Triantafyllos Chavakis (T)

Institute for Clinical Chemistry and Laboratory Medicine, University Medical Center Dresden, Technische Universität (TU) Dresden, 01307 Dresden, Germany.

Clemens Schafmayer (C)

Department of General and Thoracic Surgery, University Medical Center Schleswig-Holstein, 24105 Kiel, Germany; Department of General Surgery, University Medicine Rostock, 18507 Rostock, Germany.

Eduard Batlle (E)

Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri i Reixac 10, 08028 Barcelona, Spain; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), 08028 Barcelona, Spain; ICREA, Pg. Lluís Companys 23, 08010 Barcelona, Spain.

Sebastian Zeissig (S)

Department of Medicine I, University Medical Center Dresden, Technische Universität (TU) Dresden, 01307 Dresden, Germany; Center for Regenerative Therapies Dresden (CRTD), Technische Universität (TU) Dresden, 01307 Dresden, Germany. Electronic address: sebastian.zeissig@tu-dresden.de.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Microbiota-dependent activation of the myeloid...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Antigènes B7 › Microbiota-dependent activation of the myeloid...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Microbiota-dependent activation of the myeloid...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Phosphoprotein Phosphatases › Calcineurine › Microbiota-dependent activation of the myeloid...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du rectum › Tumeurs colorectales › Microbiota-dependent activation of the myeloid...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Microbiota-dependent activation of the myeloid...
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Microbiota-dependent activation of the myeloid...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription NFATC › Microbiota-dependent activation of the myeloid...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Antigènes B7 › V-set domain-containing T-cell activation inhibitor 1 › Microbiota-dependent activation of the myeloid...