The Epidemiology of Biliary Atresia: Exploring the Role of Developmental Factors on Birth Prevalence.
maternal diabetes
prematurity
Journal
The Journal of pediatrics
ISSN: 1097-6833
Titre abrégé: J Pediatr
Pays: United States
ID NLM: 0375410
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
01
02
2022
revised:
04
03
2022
accepted:
24
03
2022
pubmed:
2
4
2022
medline:
29
6
2022
entrez:
1
4
2022
Statut:
ppublish
Résumé
To identify key epidemiologic factors relevant to fetal development that are associated with biliary atresia. This population-based registry study examined infants born in Texas between 1999 and 2014. Epidemiologic data relevant to fetal development were compared between cases of biliary atresia identified in the Texas Birth Defects Registry (n = 305) vs all live births (n = 4 689 920), and Poisson regression was used to calculate prevalence ratios (PRs) and 95% CIs. The prevalence of biliary atresia over the study period was 0.65 per 10 000 live births. Biliary atresia was positively associated with female sex (adjusted PR, 1.68; 95% CI, 1.33-2.12), delivery before 32-37 weeks of gestation (adjusted PR, 1.64; 95% CI, 1.18-2.29), delivery before 32 weeks of gestation (adjusted PR, 3.85; 95% CI, 2.38-6.22), and non-Hispanic Black vs non-Hispanic White maternal race/ethnicity (adjusted PR, 1.54, 95% CI, 1.06-2.24), while biliary atresia was inversely associated with season of conception in the fall relative to spring (adjusted PR, 0.62; 95% CI, 0.45-0.86). In addition, biliary atresia was associated with maternal diabetes (adjusted PR, 2.34; 95% CI, 1.57-3.48), with a stronger association with pregestational diabetes compared with gestational diabetes. In subgroup analyses, these associations were present in isolated biliary atresia cases that do not have any additional birth defects. Biliary atresia is associated with multiple factors related to fetal development, including pregestational maternal diabetes, female sex, and preterm birth. These associations also were observed in isolated cases of biliary atresia without other malformations or laterality defects. Our results are consistent with early life events influencing the pathogenesis of biliary atresia, and support further studies investigating in utero events to better understand etiology and time of onset.
Identifiants
pubmed: 35364097
pii: S0022-3476(22)00288-8
doi: 10.1016/j.jpeds.2022.03.038
pmc: PMC9332904
mid: NIHMS1794335
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
89-94.e2Subventions
Organisme : NIDDK NIH HHS
ID : K23 DK109207
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES030285
Pays : United States
Organisme : NIDDK NIH HHS
ID : R03 DK128535
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
Références
Ann Intern Med. 2014 Mar 18;160(6):414-20
pubmed: 24424622
Birth Defects Res A Clin Mol Teratol. 2012 Nov;94(11):882-92
pubmed: 22945287
Pediatrics. 2008 Mar;121(3):517-21
pubmed: 18310200
J Pediatr Surg. 2007 Dec;42(12):2090-2
pubmed: 18082714
J Pediatr Gastroenterol Nutr. 2019 Oct;69(4):396-403
pubmed: 31335837
J Pediatr Gastroenterol Nutr. 2017 Oct;65(4):370-374
pubmed: 28727655
J Pediatr. 2013 Jul;163(1):100-3.e1
pubmed: 23414661
Birth Defects Res. 2021 Mar 15;113(5):439-445
pubmed: 33275842
Ophthalmic Epidemiol. 2021 Oct;28(5):428-435
pubmed: 33345678
Hepatology. 2011 Nov;54(5):1893-4
pubmed: 21748760
Pediatrics. 2011 Dec;128(6):e1428-33
pubmed: 22106076
Am J Obstet Gynecol. 2020 Feb;222(2):176.e1-176.e11
pubmed: 31454511
J Pediatr. 2002 Aug;141(2):217-22
pubmed: 12183717
J Pediatr Gastroenterol Nutr. 2013 Apr;56(4):344-54
pubmed: 23263590
Paediatr Perinat Epidemiol. 2004 Mar;18(2):97-105
pubmed: 14996248
J Pediatr Gastroenterol Nutr. 2013 Oct;57(4):e22-3
pubmed: 22847464
Pediatrics. 1997 Mar;99(3):376-82
pubmed: 9041292
J Pediatr. 2006 Sep;149(3):393-400
pubmed: 16939755
Surgery. 1993 Jun;113(6):662-8
pubmed: 8506525
J Pediatr. 1982 May;100(5):749-53
pubmed: 7069535
Hepatology. 2013 Nov;58(5):1724-31
pubmed: 23703680
Am J Med Genet A. 2007 Oct 1;143A(19):2274-84
pubmed: 17726689
Z Kinderchir. 1988 Apr;43(2):68-71
pubmed: 3388982
J Korean Med Sci. 2017 Apr;32(4):656-660
pubmed: 28244293
J Pediatr Gastroenterol Nutr. 2015 Aug;61(2):167-75
pubmed: 25658057
Birth Defects Res. 2021 Jan 1;113(1):43-54
pubmed: 33091229
J Hepatol. 1999 Dec;31(6):1006-13
pubmed: 10604573
J Pediatr Surg. 1990 Oct;25(10):1076-80; discussion 1081
pubmed: 2262862