Temporal dynamics of fMRI signal changes during conditioned interoceptive pain-related fear and safety acquisition and extinction.
Differential fear conditioning
FMRI
Gut-brain axis
Pain-related fear
Safety learning
Temporal dynamics
Journal
Behavioural brain research
ISSN: 1872-7549
Titre abrégé: Behav Brain Res
Pays: Netherlands
ID NLM: 8004872
Informations de publication
Date de publication:
03 06 2022
03 06 2022
Historique:
received:
19
10
2021
revised:
14
03
2022
accepted:
28
03
2022
pubmed:
2
4
2022
medline:
21
4
2022
entrez:
1
4
2022
Statut:
ppublish
Résumé
Associative learning and memory mechanisms drive interoceptive signaling along the gut-brain axis, thus shaping affective-emotional reactions and behavior. Specifically, learning to predict potentially harmful, visceral pain is assumed to succeed within very few trials. However, the temporal dynamics of cerebellar and cerebral fMRI signal changes underlying early acquisition and extinction of learned fear signals and the concomitant evolvement of safety learning remain incompletely understood. 3 T fMRI data of healthy individuals from three studies were uniformly processed across the whole brain and the cerebellum. All studies employed differential delay conditioning (N = 94) with one visual cue (CS
Identifiants
pubmed: 35364111
pii: S0166-4328(22)00136-X
doi: 10.1016/j.bbr.2022.113868
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
113868Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.