Laboratory and clinical predictors of focal involvement and bacteremia in brucellosis.
Bacteremia
Brucellosis
Complication
Focal involvement
Predictive values
Journal
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
ISSN: 1435-4373
Titre abrégé: Eur J Clin Microbiol Infect Dis
Pays: Germany
ID NLM: 8804297
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
received:
31
12
2021
accepted:
21
03
2022
pubmed:
3
4
2022
medline:
27
4
2022
entrez:
2
4
2022
Statut:
ppublish
Résumé
Early diagnosis of organ involvement and bacteremia in brucellosis increases treatment success and may prevent poor clinical outcomes. This study aimed to investigate the predictors of focal involvement and bacteremia in patients with brucellosis. A total of 139 brucellosis patients aged 16 years and older were included in the study. Patients with and without organ involvement and bacteremic and non-bacteremic patients were compared separately. Low back pain, lymphadenomegaly, absence of fever on admission, ESR, AST, and neutrophil-lymphocyte ratio (NLR) were predictors of focal involvement (OR: 2.604; 3.167; 7.224; 1.039; 1.032; 1.738, respectively). The AUC value of ESR was 0.669 (0.573-0.765, p = 0.002) with the cutoff point > 30 mm/h (sensitivity 89.74% and specificity 37.00%) in predicting focal involvement in patients with brucellosis. Myalgia and headache (OR: 2.970; 2692) were defined as clinical predictors of Brucella bacteremia. Focal involvement should be considered in patients with brucellosis in the absence of myalgia and fever, presence of low back pain, and sedimentation > 30 mm/h. Brucella bacteremia should be considered regardless of fever, especially in patients with myalgia and headache in endemic areas.
Identifiants
pubmed: 35364783
doi: 10.1007/s10096-022-04436-1
pii: 10.1007/s10096-022-04436-1
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
793-801Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
Pappas G, Papadimitriou P, Akritidis N, Christou L, Tsianos EV (2006) The new global map of human brucellosis. Lancet Infect Dis. https://doi.org/10.1016/S1473-3099(06)70382-6
doi: 10.1016/S1473-3099(06)70382-6
pubmed: 16439329
Skalsky K, Yahav D, Bishara J, Pitlik S, Leibovici L, Paul M (2008) Treatment of human brucellosis: systematic review and meta-analysis of randomised controlled trials. BMJ. https://doi.org/10.1136/bmj.39497.500903.25
doi: 10.1136/bmj.39497.500903.25
pubmed: 18321957
pmcid: 2276295
Young EJ. Brucella species (2005) In: Mandell GL, Bennett JE, Dolin R (eds). Principles and practice of infectious diseases. 6th edn., Philadelphia: Churchill Livingstone, pp. 2669–72
Galińska EM, Zagórski J (2013) Brucellosis in humans-etiology, diagnostics, clinical forms. Ann Agric Environ Med 20(2):233–238
pubmed: 23772567
Araj GF (2010) Update on laboratory diagnosis of human brucellosis. Int J Antimicrob Agents. https://doi.org/10.1016/j.ijantimicag.2010.06.014
doi: 10.1016/j.ijantimicag.2010.06.014
pubmed: 20692128
Mantur BG, Amarnath SK, Shinde RS (2007) Review of clinical and laboratory features of human brucellosis. Indian J Med Microbiol. https://doi.org/10.4103/0255-0857.34758
doi: 10.4103/0255-0857.34758
pubmed: 17901634
Araj GF (1999) Human brucellosis: a classical infectious disease with persistent diagnostic challenges. Clin Lab Sci 12(4):207–212
pubmed: 10558306
Pappas G, Akritidis N, Bosilkovski M, Tsianos E (2005) Brucellosis. N Engl J Med. https://doi.org/10.1056/NEJMra050570
doi: 10.1056/NEJMra050570
pubmed: 15930423
Wilkinson PC (1996) Immunoglobulin patterns of antibodies against Brucella in man and animals. J Immunol 96(3):457–463
Shi Y, Gao H, Pappas G et al (2018) Clinical features of 2041 human brucellosis cases in China. PLoS ONE. https://doi.org/10.1371/journal.pone.0205500
doi: 10.1371/journal.pone.0205500
pubmed: 30571739
pmcid: 6301672
HasanjaniRoushan MR, Mohrez M, SmailnejadGangi SM, SoleimaniAmiri MJ, Hajiahmadi M (2004) Epidemiological features and clinical manifestations in 469 adult patients with brucellosis in Babol, Northern Iran. Epidemiol Infect. https://doi.org/10.1017/s0950268804002833
doi: 10.1017/s0950268804002833
Bosilkovski M, Krteva L, Dimzova M, Vidinic I, Sopova Z, Spasovska K (2010) Human brucellosis in Macedonia - 10 years of clinical experience in endemic region. Croat Med J. https://doi.org/10.3325/cmj.2010.51.327
doi: 10.3325/cmj.2010.51.327
pubmed: 20718086
pmcid: 2931438
Eroglu E, Kandemir B (2020) Brucellosis: evaluation of two hundred and ten cases with different clinical features. Ann Acad Med Singap 49(7):462–467
doi: 10.47102/annals-acadmedsg.202053
Güler M, Avcı M, Gökgöz A (2019) Ninety-six cases of brucellosis: a retrospective evaluation. Klimik Derg 32(2):168–173
doi: 10.5152/kd.2019.37
Kerget F, Kerget B, Çelik N, İba Yılmaz S (2021) Specific tests and inflammatory biomarkers in the evaluation of brucellosis disease. Mikrobiyol Bul. https://doi.org/10.5578/mb.20219901
doi: 10.5578/mb.20219901
pubmed: 33882646
Colmenero JD, Reguera JM, Martos F et al (1996) Complications associated with Brucella melitensis infection: a study of 530 cases. Medicine (Baltimore). https://doi.org/10.1097/00005792-199607000
doi: 10.1097/00005792-199607000
Xu N, Dong X, Yao Y et al (2020) Improved early detection of focal brucellosis complications with anti-Brucella IgG. J Clin Microbiol. https://doi.org/10.1128/JCM.00903-20
doi: 10.1128/JCM.00903-20
pubmed: 32878947
pmcid: 7587116
Demirdal T, Sen P (2020) Risk factors for focal involvement in brucellosis. Diagn Microbiol Infect Dis. https://doi.org/10.1016/j.diagmicrobio.2020.115003
doi: 10.1016/j.diagmicrobio.2020.115003
pubmed: 32253073
Kayaaslan B, Bastug A, Aydin E et al (2016) A long-term survey of brucellosis: is there any marker to predict the complicated cases? Infect Dis (Lond). https://doi.org/10.3109/23744235.2015.1107187
doi: 10.3109/23744235.2015.1107187
Kursun E, Turunc T, Demiroglu Y, Arslan H (2013) Evaluation of four hundred and forty seven brucellosis cases. Intern Med. https://doi.org/10.2169/internalmedicine.52.9048
doi: 10.2169/internalmedicine.52.9048
pubmed: 23545668
Buzgan T, Karahocagil MK, Irmak H et al (2010) Clinical manifestations and complications in 1028 cases of brucellosis: a retrospective evaluation and review of the literature. Int J Infect Dis. https://doi.org/10.1016/j.ijid.2009.06.031
doi: 10.1016/j.ijid.2009.06.031
pubmed: 19910232
Shaalan MA, Memish ZA, Mahmoud SA et al (2002) Brucellosis in children: clinical observations in 115 cases. Int J Infect Dis. https://doi.org/10.1016/s1201-9712(02)90108-6
doi: 10.1016/s1201-9712(02)90108-6
pubmed: 12718832
Bukhari EE (2018) Pediatric brucellosis. An update review for the new millennium. Saudi Med J. https://doi.org/10.15537/smj.2018.4.21896
doi: 10.15537/smj.2018.4.21896
pubmed: 29619483
pmcid: 5938645
Sen P, Demirdal T, Nemli SA (2019) Predictive value of inflammation markers in brucellosis. Arch Iran Med 22(11):640–645
pubmed: 31823629
Balın ŞÖ, Tartar AS, Akbulut A (2018) The predictive role of haematological parameters in the diagnosis of osteoarticular brucellosis. Afr Health Sci. https://doi.org/10.4314/ahs.v18i4.19
doi: 10.4314/ahs.v18i4.19
pubmed: 30766564
pmcid: 6354860
Ben-Shimol S, Farahvar S, Fruchtman Y, Justman N (2020) Factors associated with single and recurrent bacteremia in childhood brucellosis. J Pediatric Infect Dis Soc. https://doi.org/10.1093/jpids/piz092
doi: 10.1093/jpids/piz092
pubmed: 31840752
Qie C, Cui J, Liu Y, Li Y, Wu H, Mi Y (2020) Epidemiological and clinical characteristics of bacteremic brucellosis. J Int Med Res. https://doi.org/10.1177/0300060520936829
doi: 10.1177/0300060520936829
pubmed: 32644831
pmcid: 7350054
Apa H, Devrim I, Memur S et al (2013) Factors affecting Brucella spp. blood cultures positivity in children. Vector Borne Zoonotic Dis. https://doi.org/10.1089/vbz.2012.0997
doi: 10.1089/vbz.2012.0997
pubmed: 23560724
Kadanali A, Ozden K, Altoparlak U, Erturk A, Parlak M (2009) Bacteremic and nonbacteremic brucellosis: clinical and laboratory observations. Infection. https://doi.org/10.1007/s15010-008-7353-3
doi: 10.1007/s15010-008-7353-3
pubmed: 19139815
Shi C, Wang L, Lv D et al (2021) Epidemiological, clinical and laboratory characteristics of patients with Brucella infection in Anhui Province, China. Infect Drug Resist. https://doi.org/10.2147/IDR.S319595
doi: 10.2147/IDR.S319595
pubmed: 34908848
pmcid: 8664647
Jacobsson G, Dashti S, Wahlberg T, Andersson R (2007) The epidemiology of and risk factors for invasive Staphylococcus aureus infections in western Sweden. Scand J Infect. https://doi.org/10.1080/00365540600810026
doi: 10.1080/00365540600810026
Erdem H, Kilic S, Sener B et al (2013) Diagnosis of chronic brucellar meningitis and meningoencephalitis: the results of the Istanbul-2 study. Clin Microbiol Infect. https://doi.org/10.1111/1469-0691.12092
doi: 10.1111/1469-0691.12092
pubmed: 24118178
Gómez MC, Nieto JA, Rosa C et al (2008) Evaluation of seven tests for diagnosis of human brucellosis in an area where the disease is endemic. Clin Vaccine Immunol. https://doi.org/10.1128/CVI.00424-07
doi: 10.1128/CVI.00424-07
pubmed: 18448622
pmcid: 2446629
Uysal B, Mumcu N, Yıldız O, Aygen B (2021) Comparison of the methods used in the diagnosis of brucellosis. Klimik Derg. https://doi.org/10.36519/kd.2021.3548
doi: 10.36519/kd.2021.3548
Gazapo E, Gonzalez Lahoz J, Subiza JL, Baquero M, Gil J, de la Concha EG (1989) Changes in IgM and IgG antibody concentrations in brucellosis over time: importance for diagnosis and follow-up. J Infect Dis. https://doi.org/10.1093/infdis/159.2.219
doi: 10.1093/infdis/159.2.219
pubmed: 2915152
Kutlu SS, Celikbaş A, Ergönül O, et al (2003) The value of the immunoglobulin G avidity test for the serologic diagnosis of brucellosis. Mikrobiyol Bul. PMID: 14748263