Extremely premature infants born at 23-25 weeks gestation are at substantial risk for pulmonary hypertension.
Journal
Journal of perinatology : official journal of the California Perinatal Association
ISSN: 1476-5543
Titre abrégé: J Perinatol
Pays: United States
ID NLM: 8501884
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
22
08
2021
accepted:
17
03
2022
revised:
22
02
2022
pubmed:
3
4
2022
medline:
14
6
2022
entrez:
2
4
2022
Statut:
ppublish
Résumé
Extremely low gestational age newborns (ELGANs) represent an especially vulnerable population. Herein, we aimed to determine incidence and severity of pulmonary hypertension associated with bronchopulmonary dysplasia (BPD-PH) in extremely immature ELGANs (gestational age: 23 In this prospective observational cohort study, we assessed BPD-PH by means of several echocardiography markers and serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels at 3 and 12 months of chronological age. In addition, we analyzed incidence and efficacy of pharmacologic treatment for BPD-PH. At 3 months 15/34 ELGANs had echocardiographic evidence of BPD-PH, while at 12 months of age 6/34 still had PH. PH-targeted therapy consisted of sildenafil monotherapy in 11 and dual oral combination therapy (sildenafil and macitentan) in four ELGANs at 3 and 12 months. 44% (15/34) of ELGANs developed BPD-PH. All received PH-targeted pharmacotherapy at 3 months, leading to hemodynamic improvements at 12 months in most infants.
Identifiants
pubmed: 35365772
doi: 10.1038/s41372-022-01374-w
pii: 10.1038/s41372-022-01374-w
pmc: PMC9184271
doi:
Substances chimiques
Biomarkers
0
Sildenafil Citrate
BW9B0ZE037
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
781-787Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2022. The Author(s).
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