In vivo imaging of microenvironmental and anti-PD-L1-mediated dynamics in cancer using S100A8/S100A9 as an imaging biomarker.

Animals Biomarkers Breast Neoplasms / metabolism Calgranulin A / genetics Calgranulin B / genetics Female Humans Immune Checkpoint Inhibitors Mice Rats Tumor Microenvironment
MRP8/MRP14 Molecular imaging S100A8/S100A9 Target-specific imaging Tumor microenvironment

Journal

Neoplasia (New York, N.Y.)
ISSN: 1476-5586
Titre abrégé: Neoplasia
Pays: United States
ID NLM: 100886622

Informations de publication

Date de publication:
06 2022
Historique:
received: 22 12 2021
accepted: 22 03 2022
pubmed: 4 4 2022
medline: 29 4 2022
entrez: 3 4 2022
Statut: ppublish

Résumé

As a promotor of tumor invasion and tumor microenvironment (TME) formation, the protein complex S100A8/S100A9 is associated with poor prognosis. Our aim was to further evaluate its origin and regulatory effects, and to establish an imaging biomarker for TME activity. S100A9 In S100A9 Our results confirm a secretion of S100A8/S100A9 by the TME, while tumor cells do not apparently release the protein. Under immune checkpoint inhibition S100A9-imaging reports an early decrease of TME activity. Therefore, S100A9-specific imaging may serve as an imaging biomarker for TME formation and activity.

Identifiants

DOI: 10.1016/j.neo.2022.100792 PMID: 35367789 PMC: PMC8983428
pubmed: 35367789
pii: S1476-5586(22)00021-5
doi: 10.1016/j.neo.2022.100792
pmc: PMC8983428
pii:
doi:

Substances chimiques

Biomarkers 0
Calgranulin A 0
Calgranulin B 0
Immune Checkpoint Inhibitors 0
S100A9 protein, mouse 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

100792

Informations de copyright

Copyright © 2022. Published by Elsevier Inc.

Déclaration de conflit d'intérêts

Declaration of Competing Interests The authors have no relevant financial or non-financial interests to disclose.

Auteurs

Anne Helfen (A)

Department of Radiology, University Hospital Muenster, University of Muenster, D-48149 Muenster, Germany. Electronic address: anne.helfen@ukmuenster.de.

Jan Rieß (J)

Department of Radiology, University Hospital Muenster, University of Muenster, D-48149 Muenster, Germany.

Olesja Fehler (O)

Institute of Immunology, University of Muenster, D-48149 Muenster, Germany.

Miriam Stölting (M)

Department of Radiology, University Hospital Muenster, University of Muenster, D-48149 Muenster, Germany.

Zhengwen An (Z)

The CRUK City of London Cancer Centre, SE1 9RT London, UK.

Vanessa Kocman (V)

Department of Radiology, University Hospital Muenster, University of Muenster, D-48149 Muenster, Germany.

Annika Schnepel (A)

Department of Radiology, University Hospital Muenster, University of Muenster, D-48149 Muenster, Germany.

Christiane Geyer (C)

Department of Radiology, University Hospital Muenster, University of Muenster, D-48149 Muenster, Germany.

Mirjam Gerwing (M)

Department of Radiology, University Hospital Muenster, University of Muenster, D-48149 Muenster, Germany.

Max Masthoff (M)

Department of Radiology, University Hospital Muenster, University of Muenster, D-48149 Muenster, Germany.

Thomas Vogl (T)

Institute of Immunology, University of Muenster, D-48149 Muenster, Germany.

Carsten Höltke (C)

Department of Radiology, University Hospital Muenster, University of Muenster, D-48149 Muenster, Germany.

Johannes Roth (J)

Institute of Immunology, University of Muenster, D-48149 Muenster, Germany.

Tony Ng (T)

The CRUK City of London Cancer Centre, SE1 9RT London, UK; UCL Cancer Institute, University College London, SE1 9RT London, UK; School of Cancer and Pharmaceutical Sciences, King´s College London, SE1 9RT London, UK.

Moritz Wildgruber (M)

Department of Radiology, University Hospital Muenster, University of Muenster, D-48149 Muenster, Germany; Department for Radiology, LMU Munich, D-81377 Munich, Germany.

Michel Eisenblätter (M)

Department of Radiology, University Hospital Muenster, University of Muenster, D-48149 Muenster, Germany; Department of Diagnostic and Interventional Radiology, Medical Center - University of Freiburg, D-79106 Freiburg, Germany.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › In vivo imaging of microenvironmental and...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › In vivo imaging of microenvironmental and...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › In vivo imaging of microenvironmental and...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de surface › Complexe antigénique L1 leucocytaire › Calgranuline A › In vivo imaging of microenvironmental and...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de surface › Complexe antigénique L1 leucocytaire › Calgranuline B › In vivo imaging of microenvironmental and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › In vivo imaging of microenvironmental and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Antinéoplasiques immunologiques › Inhibiteurs de points de contrôle immunitaires › In vivo imaging of microenvironmental and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › In vivo imaging of microenvironmental and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › In vivo imaging of microenvironmental and...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › In vivo imaging of microenvironmental and...