Phylogeny, Antifungal Susceptibility, and Point Mutations of
Phe397Leu substitution
T. indotineae
antifungal susceptibility testing
dermatophytes
dermatophytosis
point mutation
squalene epoxidase
terbinafine resistance
Journal
Frontiers in cellular and infection microbiology
ISSN: 2235-2988
Titre abrégé: Front Cell Infect Microbiol
Pays: Switzerland
ID NLM: 101585359
Informations de publication
Date de publication:
2022
2022
Historique:
received:
10
01
2022
accepted:
11
02
2022
entrez:
4
4
2022
pubmed:
5
4
2022
medline:
6
4
2022
Statut:
epublish
Résumé
Drug resistance is one of the major challenges to skin fungal infections, especially in tropical and subtropical infections caused by dermatophytes. This study aimed to determine the antifungal susceptibility of clinically dermatophytes and evaluate point mutations in terbinafine-resistant isolates. A total number of 123 clinical dermatophyte isolates in eight species were evaluated in terms of sensitivity to seven major antifungals. Furthermore, the point mutation in squalene epoxidase (
Identifiants
pubmed: 35372131
doi: 10.3389/fcimb.2022.851769
pmc: PMC8972121
doi:
Substances chimiques
Antifungal Agents
0
Squalene Monooxygenase
EC 1.14.14.17
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
851769Informations de copyright
Copyright © 2022 Pashootan, Shams-Ghahfarokhi, Chaichi Nusrati, Salehi, Asmar and Razzaghi-Abyaneh.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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