Anti-Inflammatory Drugs Decrease the PD-L1 Expression and Increase the CD8+ T-Cell Infiltration.
Journal
Cancer prevention research (Philadelphia, Pa.)
ISSN: 1940-6215
Titre abrégé: Cancer Prev Res (Phila)
Pays: United States
ID NLM: 101479409
Informations de publication
Date de publication:
01 04 2022
01 04 2022
Historique:
received:
28
01
2022
revised:
08
02
2022
accepted:
08
02
2022
entrez:
4
4
2022
pubmed:
5
4
2022
medline:
6
4
2022
Statut:
ppublish
Résumé
In this issue of Cancer Prevention Research, Cecil and colleagues show that nonsteroidal anti-inflammatory drugs (NSAID), celecoxib and naproxen, decrease the expression of programmed death-ligand 1 (PD-L1) and increase the influx of Type I tumor-infiltrating lymphocytes in colonic tumors. Importantly, both decrease of PD-L1 expression and increase of CD8+ T cells were associated with the inhibition of COX-2/PGE2 pathway in vitro and syngeneic colonic tumor xenograft models. This study clearly suggests that NSAIDs regulate the intratumoral immunity multiple ways, including suppression of expression of immune checkpoint blockade. Thus, NSAIDs should be considered as chemopreventive for patients with PD-L1-positive colonic polyp. See related article, p. 225.
Identifiants
pubmed: 35373258
pii: 682289
doi: 10.1158/1940-6207.CAPR-22-0052
doi:
Substances chimiques
Anti-Inflammatory Agents
0
B7-H1 Antigen
0
CD274 protein, human
0
Types de publication
Editorial
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
209-211Commentaires et corrections
Type : CommentOn
Informations de copyright
©2022 American Association for Cancer Research.