Screening of commonly prescribed drugs for effects on the CAT1-mediated transport of L-arginine and arginine derivatives.
ADMA
CAT1
Inhibition
L-Arginine
L-Homoarginine
Journal
Amino acids
ISSN: 1438-2199
Titre abrégé: Amino Acids
Pays: Austria
ID NLM: 9200312
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
received:
31
08
2021
accepted:
13
03
2022
pubmed:
5
4
2022
medline:
25
6
2022
entrez:
4
4
2022
Statut:
ppublish
Résumé
The cationic amino acid transporter 1 (CAT1/SLC7A1) plays a key role in the cellular uptake or export of L-arginine and some of its derivatives. This study investigated the effect of 113 chemically diverse and commonly used drugs (at 20 and 200 µM) on the CAT1-mediated cellular uptake of L-arginine, L-homoarginine, and asymmetric dimethylarginine (ADMA). Twenty-three (20%) of the tested substances showed weak inhibitory or stimulatory effects, but only verapamil showed consistent inhibitory effects on CAT1-mediated transport of all tested substrates.
Identifiants
pubmed: 35377022
doi: 10.1007/s00726-022-03156-2
pii: 10.1007/s00726-022-03156-2
pmc: PMC9217908
doi:
Substances chimiques
Cationic Amino Acid Transporter 1
0
Homoarginine
156-86-5
Arginine
94ZLA3W45F
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1101-1108Informations de copyright
© 2022. The Author(s).
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