Genome-wide Association Meta-analysis of Childhood and Adolescent Internalizing Symptoms.

Adolescent Adult Aggression Anxiety / genetics Attention Deficit Disorder with Hyperactivity / genetics Autistic Disorder / genetics Bipolar Disorder Child Child, Preschool Depression / genetics Genome-Wide Association Study Humans Loneliness Polymorphism, Single Nucleotide Schizophrenia Sleep Initiation and Maintenance Disorders / genetics
anxiety depression genetic epidemiology molecular genetics repeated measures

Journal

Journal of the American Academy of Child and Adolescent Psychiatry
ISSN: 1527-5418
Titre abrégé: J Am Acad Child Adolesc Psychiatry
Pays: United States
ID NLM: 8704565

Informations de publication

Date de publication:
07 2022
Historique:
received: 29 09 2020
revised: 15 10 2021
accepted: 25 03 2022
pubmed: 5 4 2022
medline: 6 7 2022
entrez: 4 4 2022
Statut: ppublish

Résumé

To investigate the genetic architecture of internalizing symptoms in childhood and adolescence. In 22 cohorts, multiple univariate genome-wide association studies (GWASs) were performed using repeated assessments of internalizing symptoms, in a total of 64,561 children and adolescents between 3 and 18 years of age. Results were aggregated in meta-analyses that accounted for sample overlap, first using all available data, and then using subsets of measurements grouped by rater, age, and instrument. The meta-analysis of overall internalizing symptoms (INT Genetic correlations indicate that childhood and adolescent internalizing symptoms share substantial genetic vulnerabilities with adult internalizing disorders and other childhood psychiatric traits, which could partially explain both the persistence of internalizing symptoms over time and the high comorbidity among childhood psychiatric traits. Reducing phenotypic heterogeneity in childhood samples will be key in paving the way to future GWAS success.

Identifiants

DOI: 10.1016/j.jaac.2021.11.035 PMID: 35378236
pubmed: 35378236
pii: S0890-8567(22)00179-4
doi: 10.1016/j.jaac.2021.11.035
pii:
doi:

Types de publication

Journal Article Meta-Analysis Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

934-945

Subventions

Organisme : Medical Research Council
ID : MR/S019669/1
Pays : United Kingdom

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Eshim S Jami (ES)

Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; University College London, London, United Kingdom. Electronic address: e.shahid@ucl.ac.uk.

Anke R Hammerschlag (AR)

Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Amsterdam Public Health Research Institute, Amsterdam, the Netherlands; Child Health Research Centre, University of Queensland, Brisbane, Australia.

Hill F Ip (HF)

Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.

Andrea G Allegrini (AG)

University College London, London, United Kingdom; Social, Genetic and Developmental Psychiatry Centre, King's College London, London, United Kingdom.

Beben Benyamin (B)

University of South Australia, Adelaide, Australia; South Australian Health and Medical Research Institute, Adelaide, Australia.

Richard Border (R)

Institute for Behavioral Genetics, University of Colorado Boulder.

Elizabeth W Diemer (EW)

Erasmus University Medical Center, Rotterdam, the Netherlands; Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

Chang Jiang (C)

Michigan State University, East Lansing; University of Florida, Gainesville.

Ville Karhunen (V)

Imperial College London, United Kingdom.

Yi Lu (Y)

Karolinska Institutet, Stockholm, Sweden.

Qing Lu (Q)

Michigan State University, East Lansing.

Travis T Mallard (TT)

University of Texas, Austin.

Pashupati P Mishra (PP)

Tampere University, Tampere, Finland, and Fimlab Laboratories, Tampere, Finland.

Ilja M Nolte (IM)

University of Groningen, University Medical Center Groningen, the Netherlands.

Teemu Palviainen (T)

Institute for Molecular Medicine Finland - FIMM, University of Helsinki, Finland.

Roseann E Peterson (RE)

Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond.

Hannah M Sallis (HM)

School of Psychological Science, University of Bristol, United Kingdom, and Medical Research Council (MRC) Integrative Epidemiology Unit, University of Bristol, United Kingdom; Centre for Academic Mental Health, Population Health Sciences, University of Bristol, United Kingdom.

Andrey A Shabalin (AA)

University of Utah, Salt Lake City.

Ashley E Tate (AE)

Karolinska Institutet, Stockholm, Sweden.

Elisabeth Thiering (E)

Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany; Ludwig-Maximilians-Universität, Munich, Germany.

Natàlia Vilor-Tejedor (N)

Erasmus University Medical Center, Rotterdam, the Netherlands; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain; BarcelonaBeta Brain Research Center, (BBRC) Pasqual Maragall Foundation, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain.

Carol Wang (C)

School of Medicine and Public Health, University of Newcastle, Australia.

Ang Zhou (A)

University of South Australia, Adelaide, Australia.

Daniel E Adkins (DE)

University of Utah, Salt Lake City.

Silvia Alemany (S)

Universitat Pompeu Fabra (UPF), Barcelona, Spain; SGlobal, Barcelona Institute of Global Health, Barcelona, Spain; and CIBER Epidemiología y Salud Pública (CIBERESP), Spain.

Helga Ask (H)

Norwegian Institute of Public Health, Oslo, Norway.

Qi Chen (Q)

Karolinska Institutet, Stockholm, Sweden.

Robin P Corley (RP)

Institute for Behavioral Genetics, University of Colorado Boulder.

Erik A Ehli (EA)

Avera Institute for Human Genetics, Avera McKennan Hospital & University Health Center, Sioux Falls, South Dakota.

Luke M Evans (LM)

Institute for Behavioral Genetics, University of Colorado Boulder.

Alexandra Havdahl (A)

Norwegian Institute of Public Health, Oslo, Norway.

Fiona A Hagenbeek (FA)

Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Amsterdam Public Health Research Institute, Amsterdam, the Netherlands.

Christian Hakulinen (C)

University of Helsinki, Helsinki, Finland.

Anjali K Henders (AK)

Institute for Molecular Biosciences, University of Queensland, Brisbane, Australia.

Jouke Jan Hottenga (JJ)

Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.

Tellervo Korhonen (T)

Institute for Molecular Medicine Finland - FIMM, University of Helsinki, Finland.

Abdullah Mamun (A)

Institute for Social Science Research, University of Queensland, Brisbane, Australia.

Shelby Marrington (S)

School of Public Health, University of Queensland, Brisbane, Australia.

Alexander Neumann (A)

Erasmus University Medical Center, Rotterdam, the Netherlands; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada.

Kaili Rimfeld (K)

Social, Genetic and Developmental Psychiatry Centre, King's College London, London, United Kingdom.

Fernando Rivadeneira (F)

Erasmus University Medical Center, Rotterdam, the Netherlands.

Judy L Silberg (JL)

Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond.

Catharina E van Beijsterveldt (CE)

Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.

Eero Vuoksimaa (E)

Institute for Molecular Medicine Finland - FIMM, University of Helsinki, Finland.

Alyce M Whipp (AM)

Institute for Molecular Medicine Finland - FIMM, University of Helsinki, Finland.

Xiaoran Tong (X)

Michigan State University, East Lansing; University of Florida, Gainesville.

Ole A Andreassen (OA)

NORMENT Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; and Oslo University Hospital, Norway.

Dorret I Boomsma (DI)

Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.

Sandra A Brown (SA)

University of California San Diego, La Jolla.

S Alexandra Burt (SA)

Michigan State University, East Lansing.

William Copeland (W)

University of Vermont, Burlington.

Danielle M Dick (DM)

Virginia Commonwealth University, Richmond.

K Paige Harden (KP)

University of Texas, Austin.

Kathleen Mullan Harris (KM)

Carolina Population Center, University of North Carolina at Chapel Hill.

Catharina A Hartman (CA)

University of Groningen, University Medical Center Groningen, the Netherlands.

Joachim Heinrich (J)

Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany; Ludwig-Maximilians-Universität, Munich, Germany; Melbourne School of Population and Global Health, The University of Melbourne, Victoria, Australia.

John K Hewitt (JK)

Institute for Behavioral Genetics, University of Colorado Boulder.

Christian Hopfer (C)

University of Colorado, Aurora.

Elina Hypponen (E)

University of South Australia, Adelaide, Australia; South Australian Health and Medical Research Institute, Adelaide, Australia.

Marjo-Riitta Jarvelin (MR)

MRC-PHE Centre for Environment and Health, Imperial College London, United Kingdom; the Center for Life Course Health Research, University of Oulu, Oulu, Finland; and Oulu University Hospital, Oulu, Finland.

Jaakko Kaprio (J)

Institute for Molecular Medicine Finland - FIMM, University of Helsinki, Finland.

Liisa Keltikangas-Järvinen (L)

University of Helsinki, Helsinki, Finland.

Kelly L Klump (KL)

Michigan State University, East Lansing.

Kenneth Krauter (K)

University of Colorado Boulder.

Ralf Kuja-Halkola (R)

Karolinska Institutet, Stockholm, Sweden.

Henrik Larsson (H)

Karolinska Institutet, Stockholm, Sweden.

Terho Lehtimäki (T)

Tampere University, Tampere, Finland, and Fimlab Laboratories, Tampere, Finland.

Paul Lichtenstein (P)

Karolinska Institutet, Stockholm, Sweden.

Sebastian Lundström (S)

University of Gothenburg, Sweden.

Hermine H Maes (HH)

Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond; Massey Cancer Center, Virginia Commonwealth University, Richmond.

Per Magnus (P)

Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.

Marcus R Munafò (MR)

School of Psychological Science, University of Bristol, United Kingdom, and Medical Research Council (MRC) Integrative Epidemiology Unit, University of Bristol, United Kingdom; NIHR Biomedical Research Centre at the University Hospitals Bristol NHS Foundation Trust and the University of Bristol, United Kingdom.

Jake M Najman (JM)

School of Public Health, University of Queensland, Brisbane, Australia.

Pål R Njølstad (PR)

Center for Diabetes Research, University of Bergen, Bergen, Norway, and Haukeland University Hospital, Bergen, Norway.

Albertine J Oldehinkel (AJ)

University of Groningen, University Medical Center Groningen, the Netherlands.

Craig E Pennell (CE)

School of Medicine and Public Health, University of Newcastle, Australia.

Robert Plomin (R)

Social, Genetic and Developmental Psychiatry Centre, King's College London, London, United Kingdom.

Ted Reichborn-Kjennerud (T)

Norwegian Institute of Public Health, Oslo, Norway.

Chandra Reynolds (C)

University of California at Riverside, California, and Indiana University, Bloomington, Indiana.

Richard J Rose (RJ)

University of California at Riverside, California, and Indiana University, Bloomington, Indiana.

Andrew Smolen (A)

Institute for Behavioral Genetics, University of Colorado Boulder.

Harold Snieder (H)

University of Groningen, University Medical Center Groningen, the Netherlands.

Michael Stallings (M)

Institute for Behavioral Genetics, University of Colorado Boulder.

Marie Standl (M)

Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.

Jordi Sunyer (J)

Universitat Pompeu Fabra (UPF), Barcelona, Spain; SGlobal, Barcelona Institute of Global Health, Barcelona, Spain; and CIBER Epidemiología y Salud Pública (CIBERESP), Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.

Henning Tiemeier (H)

Erasmus University Medical Center, Rotterdam, the Netherlands; Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

Sally J Wadsworth (SJ)

Institute for Behavioral Genetics, University of Colorado Boulder.

Tamara L Wall (TL)

University of California San Diego, La Jolla.

Andrew J O Whitehouse (AJO)

Telethon Kids Institute, University of Western Australia, Perth.

Gail M Williams (GM)

School of Public Health, University of Queensland, Brisbane, Australia.

Eivind Ystrøm (E)

Norwegian Institute of Public Health, Oslo, Norway; PROMENTA Research Center, University of Oslo, Norway.

Michel G Nivard (MG)

Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.

Meike Bartels (M)

Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Amsterdam Public Health Research Institute, Amsterdam, the Netherlands.

Christel M Middeldorp (CM)

Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Child Health Research Centre, University of Queensland, Brisbane, Australia; Child and Youth Mental Health Service, Children's Health Queensland Hospital and Health Service, Brisbane, Australia.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Genome-wide Association Meta-analysis of...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Genome-wide Association Meta-analysis of...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Comportement social › Agressivité › Genome-wide Association Meta-analysis of...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Anxiété › Genome-wide Association Meta-analysis of...
questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Troubles déficitaires de l'attention et du comportement perturbateur › Trouble déficitaire de l'attention avec hyperactivité › Genome-wide Association Meta-analysis of...
questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Troubles généralisés du développement de l'enfant › Trouble du spectre autistique › Trouble autistique › Genome-wide Association Meta-analysis of...
questionsmedicales.fr › Troubles mentaux › Troubles de l'humeur › Troubles bipolaires et apparentés › Trouble bipolaire › Genome-wide Association Meta-analysis of...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Genome-wide Association Meta-analysis of...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Enfant d'âge préscolaire › Genome-wide Association Meta-analysis of...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Dépression › Genome-wide Association Meta-analysis of...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Genome-wide Association Meta-analysis of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genome-wide Association Meta-analysis of...
questionsmedicales.fr › Sciences sociales › Sociologie › Facteurs sociologiques › Isolement social › Solitude › Genome-wide Association Meta-analysis of...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Genome-wide Association Meta-analysis of...
questionsmedicales.fr › Troubles mentaux › Schizophrénie et troubles avec traits psychotiques › Schizophrénie › Genome-wide Association Meta-analysis of...
questionsmedicales.fr › Troubles mentaux › Troubles de la veille et du sommeil › Dyssomnies › Troubles du sommeil d'origine intrinsèque › Troubles de l'endormissement et du maintien du sommeil › Genome-wide Association Meta-analysis of...