Role and Function of Regulatory T Cell in Chronic Rhinosinusitis with Nasal Polyposis.
Journal
Journal of immunology research
ISSN: 2314-7156
Titre abrégé: J Immunol Res
Pays: Egypt
ID NLM: 101627166
Informations de publication
Date de publication:
2022
2022
Historique:
received:
26
12
2021
revised:
28
02
2022
accepted:
14
03
2022
entrez:
5
4
2022
pubmed:
6
4
2022
medline:
7
4
2022
Statut:
epublish
Résumé
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a subtype of chronic rhinosinusitis characterized by high edema in the stroma, albumin deposition, and formation of pseudocysts. The pathogenesis of CRSwNP is not yet fully understood. Regulatory T (Treg) cells are a subset of CD4+ T cells that play a suppressive immunoregulatory role in the process of CRSwNP. Recent studies have found that there was a significant reduction in Treg cells in polyp tissues, which leads to the onset of CRSwNP. An imbalance between Th17 and Treg cells can also aggravate inflammation toward the Th2 type. This review focuses on our understanding of the function and role of Treg cells and their regulatory factors and clinical significance in CRSwNP. We also summarize the current drug treatments for CRSwNP with Tregs as the potential therapeutic target, which will provide new ideas for the treatment of CRSwNP in the future.
Identifiants
pubmed: 35378904
doi: 10.1155/2022/1144563
pmc: PMC8976649
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1144563Informations de copyright
Copyright © 2022 Chenyang Lei et al.
Déclaration de conflit d'intérêts
The authors declare that there is no conflict of interest regarding the publication of this paper.
Références
Toxicol Lett. 2016 Jan 22;241:103-10
pubmed: 26617183
Nat Rev Immunol. 2014 Mar;14(3):154-65
pubmed: 24481337
Toxins (Basel). 2020 Oct 28;12(11):
pubmed: 33126405
Nature. 2006 May 11;441(7090):235-8
pubmed: 16648838
Front Immunol. 2012 Mar 21;3:51
pubmed: 22566933
Nature. 2013 Jan 3;493(7430):51-5
pubmed: 23235831
Otolaryngol Clin North Am. 2005 Dec;38(6):1257-66, ix-x
pubmed: 16326183
Int J Mol Sci. 2018 Mar 03;19(3):
pubmed: 29510522
Inflamm Res. 2013 Mar;62(3):283-9
pubmed: 23178794
Clin Exp Allergy. 2014;44(5):701-12
pubmed: 24931597
Am J Rhinol Allergy. 2014 Mar-Apr;28(2):e83-9
pubmed: 24717938
Clin Immunol. 2017 Jun;179:66-76
pubmed: 28279811
Immunity. 2007 Jul;27(1):145-59
pubmed: 17613255
Front Cell Infect Microbiol. 2018 Feb 28;8:57
pubmed: 29541629
Genes Dev. 2005 Dec 1;19(23):2783-810
pubmed: 16322555
Ann Rheum Dis. 2016 Nov;75(11):1984-1988
pubmed: 27098404
Cell. 2014 Aug 14;158(4):749-763
pubmed: 25126783
J Allergy Clin Immunol. 2009 Aug;124(2):253-9, 259.e1-2
pubmed: 19500825
Allergy. 2006 Nov;61(11):1275-9
pubmed: 17002702
Front Immunol. 2021 Apr 01;12:626193
pubmed: 33868244
PLoS One. 2012;7(8):e44056
pubmed: 22952871
Science. 2003 Feb 14;299(5609):1057-61
pubmed: 12522256
Int Immunopharmacol. 2018 Apr;57:55-61
pubmed: 29475096
Nat Genet. 2001 Jan;27(1):20-1
pubmed: 11137993
Nature. 2009 Mar 19;458(7236):351-6
pubmed: 19182775
Am J Rhinol Allergy. 2013 Sep-Oct;27(5):367-71
pubmed: 23601202
JAMA Otolaryngol Head Neck Surg. 2019 Apr 1;145(4):313-319
pubmed: 30730537
J Allergy Clin Immunol. 2010 Feb;125(2):397-403.e10
pubmed: 20159251
N Engl J Med. 2019 Jul 4;381(1):55-63
pubmed: 31269366
J Allergy Clin Immunol. 2011 Nov;128(5):989-95.e1-8
pubmed: 21958585
Rhinology. 2020 Feb 20;58(Suppl S29):1-464
pubmed: 32077450
Allergy Asthma Immunol Res. 2015 Jul;7(4):346-58
pubmed: 25936910
Allergy. 2011 Oct;66(10):1296-303
pubmed: 21575009
Nat Rev Immunol. 2017 Apr;17(4):233-247
pubmed: 28192415
J Allergy Clin Immunol Pract. 2016 Jul-Aug;4(4):584-9
pubmed: 27393772
Nat Rev Immunol. 2013 Apr;13(4):227-42
pubmed: 23470321
Nat Rev Immunol. 2016 Feb;16(2):90-101
pubmed: 26688349
Cell. 2010 Mar 19;140(6):845-58
pubmed: 20303875
Immunity. 2008 Jul 18;29(1):114-26
pubmed: 18617425
Annu Rev Immunol. 2005;23:275-306
pubmed: 15771572
J Clin Immunol. 2019 Oct;39(7):623-640
pubmed: 31478130
Nat Rev Immunol. 2004 Nov;4(11):841-55
pubmed: 15516964
J Allergy Clin Immunol. 2016 Nov;138(5):1344-1353
pubmed: 27544740
Allergy Asthma Clin Immunol. 2018 Jul 05;14:47
pubmed: 30002685
J Allergy Clin Immunol. 2017 Oct;140(4):1024-1031.e14
pubmed: 28687232
J Allergy Clin Immunol Pract. 2019 May - Jun;7(5):1700-1701
pubmed: 31076065
Autoimmun Rev. 2011 Oct;10(12):725-32
pubmed: 21763468
Allergy Asthma Clin Immunol. 2019 Jun 20;15:39
pubmed: 31249603
J Immunol. 2013 Feb 1;190(3):1076-84
pubmed: 23277487
Curr Allergy Asthma Rep. 2019 Mar 11;19(4):21
pubmed: 30859336
Sci Transl Med. 2012 Sep 12;4(151):151ra124
pubmed: 22972842
PLoS One. 2018 May 10;13(5):e0197355
pubmed: 29746583
Nat Immunol. 2007 Sep;8(9):967-74
pubmed: 17581537
Drugs. 2001;61(5):573-8
pubmed: 11368283
Sci Rep. 2018 May 21;8(1):7926
pubmed: 29784985
Nat Immunol. 2009 Jan;10(1):48-57
pubmed: 19011627
Clin Transl Immunology. 2016 Jan 08;5(1):e56
pubmed: 26900470
Eur Arch Otorhinolaryngol. 2021 Nov 11;:
pubmed: 34761301
Nat Immunol. 2007 Dec;8(12):1390-7
pubmed: 17994024
Allergy. 2020 Oct;75(10):2687-2689
pubmed: 32347979
Annu Rev Immunol. 2009;27:451-83
pubmed: 19105661
J Immunol. 2007 Jan 1;178(1):280-90
pubmed: 17182565
Curr Opin Immunol. 2015 Apr;33:101-11
pubmed: 25728990
J Immunol. 2013 May 1;190(9):4483-7
pubmed: 23543753
Eur Respir J. 2006 Jul;28(1):59-67
pubmed: 16540498
Rhinology. 2017 Sep 1;55(3):202-210
pubmed: 28501885
J Exp Med. 2005 Mar 7;201(5):723-35
pubmed: 15753206
J Allergy Clin Immunol. 2011 Oct;128(4):728-32
pubmed: 21868076
Cancer Immunol Immunother. 2012 Nov;61(11):2183-92
pubmed: 22729557
N Engl J Med. 2005 Oct 20;353(16):1711-23
pubmed: 16236742
Am J Rhinol Allergy. 2009 Sep-Oct;23(5):453-60
pubmed: 19807975
Cell. 2008 May 30;133(5):775-87
pubmed: 18510923
J Exp Med. 2003 Jul 21;198(2):235-47
pubmed: 12874257
Front Immunol. 2020 Jan 14;10:3100
pubmed: 31993063
J Otolaryngol Head Neck Surg. 2010 Oct;39(5):600-5
pubmed: 20828526
Biomed Rep. 2019 Feb;10(2):119-126
pubmed: 30719290
Front Immunol. 2015 Dec 17;6:639
pubmed: 26734006
Ann Intern Med. 2011 Mar 1;154(5):293-302
pubmed: 21357906
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Feb;30(4):277-81
pubmed: 27373033
Allergy Asthma Clin Immunol. 2016 Apr 27;12:19
pubmed: 27127525
Int Forum Allergy Rhinol. 2015 Jan;5(1):14-27
pubmed: 25332132
Int Forum Allergy Rhinol. 2015 Nov;5(11):1010-7
pubmed: 26121963
Clin Sci (Lond). 2020 Jan 31;134(2):123-138
pubmed: 31922185
Environ Microbiol. 2017 Jan;19(1):381-392
pubmed: 27902866
Oncotarget. 2018 May 18;9(38):24898-24913
pubmed: 29861841
Clin Immunol. 2010 Oct;137(1):111-21
pubmed: 20598643
Nat Immunol. 2001 Dec;2(12):1138-43
pubmed: 11702064
Immunity. 2009 Feb 20;30(2):204-17
pubmed: 19185518
Nat Immunol. 2013 Apr;14(4):307-8
pubmed: 23507634
Eur Arch Otorhinolaryngol. 2014 Oct;271(10):2729-36
pubmed: 24604680
Rhinology. 2002 Sep;40(3):118-21
pubmed: 12357710
Clin Immunol. 2013 Dec;149(3):400-10
pubmed: 24211714
World J Gastroenterol. 2015 Nov 21;21(43):12283-95
pubmed: 26604637
Immunobiology. 2011 Mar;216(3):386-92
pubmed: 20667622
Immunol Allergy Clin North Am. 2017 May;37(2):357-367
pubmed: 28366482
Molecules. 2017 Jan 14;22(1):
pubmed: 28098832
Curr Pharm Des. 2010;16(32):3540-53
pubmed: 20977419
J Allergy Clin Immunol. 2009 Sep;124(3):478-84, 484.e1-2
pubmed: 19541359
PLoS One. 2014 Dec 08;9(12):e113314
pubmed: 25485946
Allergy. 2009 Mar;64(3):335-47
pubmed: 19220222
Immunity. 2017 Jan 17;46(1):78-91
pubmed: 28099866
N Engl J Med. 2015 Oct;373(14):1329-39
pubmed: 26422723
J Allergy Clin Immunol. 2006 Nov;118(5):1133-41
pubmed: 17088140
Nat Rev Microbiol. 2017 Jul;15(7):435-447
pubmed: 28420883
Scand J Immunol. 2011 Aug;74(2):176-85
pubmed: 21375554
Allergy Rhinol (Providence). 2014 Jan;5(3):146-56
pubmed: 25565051
J Immunol. 2008 Apr 1;180(7):4785-92
pubmed: 18354202
J Allergy Clin Immunol. 2008 Nov;122(5):961-8
pubmed: 18804271
Eur Arch Otorhinolaryngol. 2013 Mar;270(4):1345-8
pubmed: 23064462
J Allergy Clin Immunol. 2013 Mar;131(3):772-80
pubmed: 23375208
Microb Cell Fact. 2020 Nov 25;19(1):215
pubmed: 33238997
Nat Med. 2014 Jan;20(1):62-8
pubmed: 24362934
Otolaryngol Head Neck Surg. 2015 Apr;152(4):598-609
pubmed: 25833927
Allergy. 2009 Oct;64(10):1539-1546
pubmed: 19392991
J Allergy Clin Immunol. 2004 Oct;114(4):981-3
pubmed: 15480349
J Allergy Clin Immunol. 2010 May;125(5):1061-8
pubmed: 20392482
Nat Med. 2013 Jun;19(6):739-46
pubmed: 23624599
Clin Exp Allergy. 2001 Dec;31(12):1923-31
pubmed: 11737045
Cell Immunol. 2004 Nov-Dec;232(1-2):57-63
pubmed: 15922716
J Inflamm (Lond). 2011 Aug 26;8(1):22
pubmed: 21871091
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020 Aug;34(8):701-705
pubmed: 32842201
J Allergy Clin Immunol. 2004 Dec;114(6):1425-33
pubmed: 15577848
Sci Rep. 2013 Nov 06;3:3153
pubmed: 24193319
J Allergy Clin Immunol. 2013 Jan;131(1):110-6.e1
pubmed: 23021878
Semin Immunol. 2013 Nov 15;25(4):305-12
pubmed: 24211039
BMC Musculoskelet Disord. 2016 Jul 16;17:290
pubmed: 27421886
J Immunol. 2014 Dec 1;193(11):5525-33
pubmed: 25348623
Allergy. 2012 Jun;67(6):732-40
pubmed: 22462754
Adv Exp Med Biol. 2015;872:217-33
pubmed: 26215996
Immunity. 2006 Sep;25(3):455-71
pubmed: 16973386
J Immunol. 2001 Oct 15;167(8):4245-53
pubmed: 11591746
Nat Rev Immunol. 2016 Nov;16(11):676-689
pubmed: 27640624
Int J Mol Sci. 2019 Mar 06;20(5):
pubmed: 30845709
Int Forum Allergy Rhinol. 2019 May;9(S1):S32-S46
pubmed: 31087632
Trends Mol Med. 2011 Nov;17(11):668-76
pubmed: 21890412
Curr Allergy Asthma Rep. 2018 Mar 24;18(4):25
pubmed: 29574586
Rhinology. 2016 Jun;54(2):134-40
pubmed: 27172454
Allergy Asthma Immunol Res. 2012 Jan;4(1):24-30
pubmed: 22211167
Clin Microbiol Rev. 2017 Jan;30(1):321-348
pubmed: 27903594
Allergy Rhinol (Providence). 2013 Summer;4(2):e69-76
pubmed: 24124640
Eur J Immunol. 2010 Jul;40(7):1830-5
pubmed: 20583029
Immunol Lett. 2013 Jul-Aug;154(1-2):42-8
pubmed: 23994430
Autoimmun Rev. 2014 Jun;13(6):668-77
pubmed: 24418308
Arthritis Res Ther. 2015 Jan 21;17:10
pubmed: 25604867
Nature. 2008 May 8;453(7192):236-40
pubmed: 18368049
Am J Rhinol Allergy. 2012 Sep-Oct;26(5):371-9
pubmed: 23168151
Am J Rhinol Allergy. 2014 Jan-Feb;28(1):e17-24
pubmed: 24717872
Am J Rhinol Allergy. 2017 Nov 1;31(6):345-351
pubmed: 29122078
Front Microbiol. 2020 Dec 17;11:607735
pubmed: 33391230
Am J Pathol. 2012 Jul;181(1):8-18
pubmed: 22640807
JAMA. 2016 Feb 2;315(5):469-79
pubmed: 26836729
Clin Exp Allergy. 2010 Sep;40(9):1323-32
pubmed: 20701615
Carcinogenesis. 2013 Jun;34(6):1296-303
pubmed: 23385062
Cold Spring Harb Perspect Biol. 2018 Mar 1;10(3):
pubmed: 28620098
Blood. 2012 Jun 14;119(24):5898-908
pubmed: 22538855
Clin Cancer Res. 2014 Feb 1;20(3):724-35
pubmed: 24297862
Rhinology. 2018 Dec 1;56(4):378-385
pubmed: 30033452
Rhinology. 2020 Aug 1;58(4):384-393
pubmed: 32333751
J Immunol. 2008 Sep 1;181(5):3285-90
pubmed: 18714000
Science. 2011 Apr 29;332(6029):600-3
pubmed: 21474713
Cancers (Basel). 2016 Mar 15;8(3):
pubmed: 26999211
Scand J Immunol. 2008 Oct;68(4):381-2
pubmed: 18782266
Front Immunol. 2016 Dec 14;7:592
pubmed: 28018358
Clin Immunol. 2013 Oct;149(1):97-110
pubmed: 23948613
Cytokine. 2018 Jan;101:14-18
pubmed: 27531077
PLoS One. 2015 May 28;10(5):e0126463
pubmed: 26020249
Ann Rheum Dis. 2015 Jun;74(6):1311-6
pubmed: 25398374
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2014 Oct;28(20):1628-32
pubmed: 25764775
J Allergy Clin Immunol. 2008 Jun;121(6):1435-41, 1441.e1-3
pubmed: 18423831
Cell Mol Immunol. 2014 Jul;11(4):387-97
pubmed: 24658435
Diabetes. 2006 Jan;55(1):158-70
pubmed: 16380489
Clin Immunol. 2008 Dec;129(3):394-400
pubmed: 18793874
Dermatol Ther (Heidelb). 2016 Jun;6(2):111-24
pubmed: 27221323
Immunol Rev. 2011 May;241(1):63-76
pubmed: 21488890
Immunity. 2009 Jun 19;30(6):899-911
pubmed: 19464196
Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19396-401
pubmed: 19036923
Allergy Rhinol (Providence). 2017 Oct 1;8(3):139-147
pubmed: 29070271