PI4P-Dependent Targeting of ATG14 to Mature Autophagosomes.

Autophagosomes / metabolism Autophagy Autophagy-Related Proteins / genetics Lysosomes / metabolism Membrane Fusion

Journal

Biochemistry
ISSN: 1520-4995
Titre abrégé: Biochemistry
Pays: United States
ID NLM: 0370623

Informations de publication

Date de publication:
19 04 2022
Historique:
pubmed: 6 4 2022
medline: 21 4 2022
entrez: 5 4 2022
Statut: ppublish

Résumé

Degradation of autophagosomal cargo requires the tethering and fusion of autophagosomes with lysosomes that is mediated by the scaffolding protein autophagy related 14 (ATG14). Here, we report that phosphatidylinositol 4-kinase 2A (PI4K2A) generates a pool of phosphatidylinositol 4-phosphate (PI4P) that facilitates the recruitment of ATG14 to mature autophagosomes. We also show that PI4K2A binds to ATG14, suggesting that PI4P may be synthesized

Identifiants

DOI: 10.1021/acs.biochem.1c00775 PMID: 35380781
pubmed: 35380781
doi: 10.1021/acs.biochem.1c00775
doi:

Substances chimiques

Autophagy-Related Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

722-729

Auteurs

Hui-Qiao Sun (HQ)

Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.

Yan Chen (Y)

School of Physics and Astronomy, University of Minnesota, Minneapolis, Minnesota 55455, United States.

Per Niklas Hedde (PN)

Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii 96813, United States.
Laboratory for Fluorescence Dynamics, Department of Biomedical Engineering, University of California, Irvine, California 92697, United States.
ORCID: 0000-0002-2994-369X

Joachim Mueller (J)

School of Physics and Astronomy, University of Minnesota, Minneapolis, Minnesota 55455, United States.

Joseph P Albanesi (JP)

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.
ORCID: 0000-0002-6864-8140

Helen Yin (H)

Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.

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Classifications MeSH

questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Phagosomes › Autophagosomes › PI4P-Dependent Targeting of ATG14 to Mature...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Autophagie › PI4P-Dependent Targeting of ATG14 to Mature...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines associées à l'autophagie › PI4P-Dependent Targeting of ATG14 to Mature...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Lysosomes › PI4P-Dependent Targeting of ATG14 to Mature...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Fusion membranaire › PI4P-Dependent Targeting of ATG14 to Mature...