SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8
Journal
Nature immunology
ISSN: 1529-2916
Titre abrégé: Nat Immunol
Pays: United States
ID NLM: 100941354
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
received:
14
12
2021
accepted:
11
03
2022
pubmed:
7
4
2022
medline:
18
5
2022
entrez:
6
4
2022
Statut:
ppublish
Résumé
Although mRNA vaccine efficacy against severe coronavirus disease 2019 remains high, variant emergence has prompted booster immunizations. However, the effects of repeated exposures to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigens on memory T cells are poorly understood. Here, we utilize major histocompatibility complex multimers with single-cell RNA sequencing to profile SARS-CoV-2-responsive T cells ex vivo from humans with one, two or three antigen exposures, including vaccination, primary infection and breakthrough infection. Exposure order determined the distribution between spike-specific and non-spike-specific responses, with vaccination after infection leading to expansion of spike-specific T cells and differentiation to CCR7
Identifiants
pubmed: 35383307
doi: 10.1038/s41590-022-01184-4
pii: 10.1038/s41590-022-01184-4
pmc: PMC9106845
mid: NIHMS1788551
doi:
Substances chimiques
Receptors, Antigen, T-Cell
0
Spike Glycoprotein, Coronavirus
0
Vaccines, Synthetic
0
mRNA Vaccines
0
spike protein, SARS-CoV-2
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
781-790Subventions
Organisme : NIAID NIH HHS
ID : U01 AI150747
Pays : United States
Organisme : NIAID NIH HHS
ID : HHSN272201400006C
Pays : United States
Organisme : NIAID NIH HHS
ID : 75N93021C00016
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI144616
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI136514
Pays : United States
Organisme : NIAID NIH HHS
ID : 75N93019C00052
Pays : United States
Investigateurs
Aditya Gaur
(A)
James Hoffman
(J)
Motomi Mori
(M)
Li Tang
(L)
Elaine Tuomanen
(E)
Richard Webby
(R)
Hana Hakim
(H)
Randall T Hayden
(RT)
Diego R Hijano
(DR)
Resha Bajracharya
(R)
Walid Awad
(W)
Lee-Ann Van de Velde
(LA)
Brandi L Clark
(BL)
Taylor L Wilson
(TL)
Aisha Souquette
(A)
Ashley Castellaw
(A)
Ronald H Dallas
(RH)
Jason Hodges
(J)
Ashleigh Gowen
(A)
Jamie Russell-Bell
(J)
James Sparks
(J)
David E Wittman
(DE)
Thomas P Fabrizio
(TP)
Sean Cherry
(S)
Ericka Kirkpatrick Roubidoux
(EK)
Valerie Cortez
(V)
Pamela Freiden
(P)
Nicholas Wohlgemuth
(N)
Kendall Whitt
(K)
Commentaires et corrections
Type : UpdateOf
Type : CommentIn
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature America, Inc.
Références
Nature. 2020 Aug;584(7821):457-462
pubmed: 32668444
Immunity. 2020 Nov 17;53(5):1095-1107.e3
pubmed: 33128877
Nat Med. 2020 Jul;26(7):1033-1036
pubmed: 32398876
Immunity. 2021 May 11;54(5):1055-1065.e5
pubmed: 33945786
Nat Med. 2021 Jan;27(1):78-85
pubmed: 33184509
Nat Commun. 2022 Jan 10;13(1):80
pubmed: 35013199
J Biomed Inform. 2019 Jul;95:103208
pubmed: 31078660
Cell Mol Immunol. 2020 May;17(5):541-543
pubmed: 32203186
Nature. 2017 Jul 6;547(7661):89-93
pubmed: 28636592
Sci Immunol. 2021 Apr 15;6(58):
pubmed: 33858945
Cell Rep. 2021 Aug 24;36(8):109570
pubmed: 34390647
Nature. 2021 Jul;595(7868):572-577
pubmed: 34044428
Sci Immunol. 2021 Apr 14;6(58):
pubmed: 33853928
J Biomed Inform. 2009 Apr;42(2):377-81
pubmed: 18929686
Nature. 2022 Jan;601(7891):110-117
pubmed: 34758478
Nat Med. 2021 Jul;27(7):1280-1289
pubmed: 34017137
Cell. 2020 Oct 1;183(1):158-168.e14
pubmed: 32979941
Pediatr Allergy Immunol. 2020 Jul;31(5):565-569
pubmed: 32319118
Cell. 2020 Jun 25;181(7):1489-1501.e15
pubmed: 32473127
Nat Immunol. 2021 Jan;22(1):74-85
pubmed: 32999467
Cell Rep Med. 2021 Jul 20;2(7):100355
pubmed: 34230917
Sci Immunol. 2022 Jan 21;7(67):eabk3070
pubmed: 34793243
Cell. 2020 Nov 12;183(4):996-1012.e19
pubmed: 33010815
J Clin Invest. 2021 Jun 15;131(12):
pubmed: 33939647
Nature. 2021 Sep;597(7875):268-273
pubmed: 34320609
Science. 2021 Apr 30;:
pubmed: 33931567
Immunity. 2021 May 11;54(5):1066-1082.e5
pubmed: 33951417
Nature. 2017 Jul 6;547(7661):94-98
pubmed: 28636589
Proc Natl Acad Sci U S A. 2020 Sep 29;117(39):24384-24391
pubmed: 32913053
Cell. 2021 Jun 24;184(13):3573-3587.e29
pubmed: 34062119
Nat Med. 2021 Jun;27(6):981-984
pubmed: 33795870
Nucleic Acids Res. 2020 Jul 2;48(W1):W449-W454
pubmed: 32406916
Sci Immunol. 2021 Jan 21;6(55):
pubmed: 33478949
Nat Immunol. 2022 Jan;23(1):50-61
pubmed: 34853448
Nature. 2020 Nov;587(7833):270-274
pubmed: 32726801
Science. 2020 Oct 2;370(6512):89-94
pubmed: 32753554
Science. 2021 Mar 12;371(6534):1103-1104
pubmed: 33707254
EBioMedicine. 2021 Jun;68:103410
pubmed: 34098342
Front Immunol. 2022 Dec 16;13:1066176
pubmed: 36591270
J Clin Invest. 2021 Mar 1;131(5):
pubmed: 33427749
Nat Biotechnol. 2022 Jan;40(1):54-63
pubmed: 34426704
Sci Immunol. 2021 May 25;6(59):
pubmed: 34035118
Elife. 2021 Jan 05;10:
pubmed: 33399535
Nat Rev Immunol. 2015 Aug;15(8):486-99
pubmed: 26205583
N Engl J Med. 2021 Apr 8;384(14):1372-1374
pubmed: 33691060
Front Immunol. 2020 May 01;11:827
pubmed: 32425950
Nat Commun. 2021 May 10;12(1):2593
pubmed: 33972535
Cell. 2022 Aug 4;185(16):2936-2951.e19
pubmed: 35931021
Nat Immunol. 2020 Nov;21(11):1336-1345
pubmed: 32887977
Nat Rev Immunol. 2022 Feb;22(2):75
pubmed: 35017722
Cell Rep Med. 2021 Feb 16;2(2):100204
pubmed: 33521695
Nature. 2021 Jul;595(7867):426-431
pubmed: 34126625
Sci Immunol. 2021 Jul 1;6(61):
pubmed: 34210785
Immunity. 2021 Jan 12;54(1):44-52.e3
pubmed: 33338412
PLoS One. 2014 Jun 10;9(6):e98679
pubmed: 24914678
Immunity. 2020 Dec 15;53(6):1245-1257.e5
pubmed: 33326767