Selenium attenuates the cadmium-induced placenta glucocorticoid barrier damage by up-regulating the expression of specificity protein 1.
11-beta-Hydroxysteroid Dehydrogenase Type 2
/ genetics
Animals
Cadmium
/ toxicity
Cadmium Poisoning
/ metabolism
Cell Line, Tumor
Female
Fetal Growth Retardation
/ chemically induced
Glucocorticoids
/ pharmacology
Humans
Placenta
/ metabolism
Pregnancy
Rats
Rats, Sprague-Dawley
Selenium
/ adverse effects
Sp1 Transcription Factor
/ biosynthesis
11β-hydroxysteroid dehydrogenase type 2(11β-HSD2)
cadmium (Cd)
rats
selenium (Se)
specificity protein 1(Sp1)
Journal
Journal of biochemical and molecular toxicology
ISSN: 1099-0461
Titre abrégé: J Biochem Mol Toxicol
Pays: United States
ID NLM: 9717231
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
revised:
26
01
2022
received:
04
03
2021
accepted:
02
03
2022
pubmed:
7
4
2022
medline:
20
7
2022
entrez:
6
4
2022
Statut:
ppublish
Résumé
Cadmium (Cd) is an environmental pollutant and pregnant women are especially susceptible to the effects of exposure to Cd. Our previous study found Cd can be accumulated in the placenta and causes fetal growth restriction (FGR) through damage the placental glucocorticoid barrier. Selenium (Se), as an essential micronutrient, can allivate Cd-induced toxicity. In this study, we aim to explore the protective mechanism of Se against Cd-induced the placental glucocorticoid barrier damage and FGR. Pregnant Sprague Dawley (SD) rats were exposed to CdCl
Substances chimiques
Glucocorticoids
0
Sp1 Transcription Factor
0
SP1 protein, human
0
Cadmium
00BH33GNGH
11-beta-Hydroxysteroid Dehydrogenase Type 2
EC 1.1.1.146
Selenium
H6241UJ22B
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e23056Subventions
Organisme : Wenzhou Municipal Science and Technology Bureau
ID : Y2020083
Informations de copyright
© 2022 Wiley Periodicals LLC.
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