Hydrazines as Substrates and Inhibitors of the Archaeal Ammonia Oxidation Pathway.
ammonia-oxidizing archaea
hydrazines
Journal
Applied and environmental microbiology
ISSN: 1098-5336
Titre abrégé: Appl Environ Microbiol
Pays: United States
ID NLM: 7605801
Informations de publication
Date de publication:
26 04 2022
26 04 2022
Historique:
pubmed:
7
4
2022
medline:
29
4
2022
entrez:
6
4
2022
Statut:
ppublish
Résumé
Ammonia-oxidizing archaea (AOA) and bacteria (AOB) perform key steps in the global nitrogen cycle, the oxidation of ammonia to nitrite. While the ammonia oxidation pathway is well characterized in AOB, many knowledge gaps remain about the metabolism of AOA. Hydroxylamine is an intermediate in both AOB and AOA, but homologues of hydroxylamine dehydrogenase (HAO), catalyzing bacterial hydroxylamine oxidation, are absent in AOA. Hydrazine is a substrate for bacterial HAO, while phenylhydrazine is a suicide inhibitor of HAO. Here, we examine the effect of hydrazines in AOA to gain insights into the archaeal ammonia oxidation pathway. We show that hydrazine is both a substrate and an inhibitor for AOA and that phenylhydrazine irreversibly inhibits archaeal hydroxylamine oxidation. Both hydrazine and phenylhydrazine interfered with ammonia and hydroxylamine oxidation in AOA. Furthermore, the AOA "
Identifiants
pubmed: 35384704
doi: 10.1128/aem.02470-21
pmc: PMC9040604
doi:
Substances chimiques
Hydrazines
0
Hydroxylamines
0
Phenylhydrazines
0
Ammonia
7664-41-7
Adenosine Triphosphate
8L70Q75FXE
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0247021Références
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