Type 2 immune polarization is associated with cardiopulmonary disease in preterm infants.

Animals Bronchopulmonary Dysplasia / etiology Female Humans Infant, Newborn Infant, Premature Inflammation / complications Interleukin-13 Lung / pathology Mice Pregnancy

Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
06 04 2022
Historique:
entrez: 6 4 2022
pubmed: 7 4 2022
medline: 9 4 2022
Statut: ppublish

Résumé

Postnatal maturation of the immune system is poorly understood, as is its impact on illnesses afflicting term or preterm infants, such as bronchopulmonary dysplasia (BPD) and BPD-associated pulmonary hypertension. These are both cardiopulmonary inflammatory diseases that cause substantial mortality and morbidity with high treatment costs. Here, we characterized blood samples collected from 51 preterm infants longitudinally at five time points, 20 healthy term infants at birth and age 3 to 16 weeks, and 5 healthy adults. We observed strong associations between type 2 immune polarization in circulating CD3

Identifiants

DOI: 10.1126/scitranslmed.aaz8454 PMID: 35385341
pubmed: 35385341
doi: 10.1126/scitranslmed.aaz8454
doi:

Substances chimiques

Interleukin-13 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

eaaz8454

Auteurs

Jason C Lao (JC)

Department of Paediatrics, Monash University, Melbourne, Victoria 3168, Australia.
Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria 3168, Australia.
ORCID: 0000-0002-4151-322X

Christine B Bui (CB)

Department of Paediatrics, Monash University, Melbourne, Victoria 3168, Australia.
Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria 3168, Australia.

Merrin A Pang (MA)

Department of Paediatrics, Monash University, Melbourne, Victoria 3168, Australia.
Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria 3168, Australia.
ORCID: 0000-0002-4449-8053

Steven X Cho (SX)

Department of Paediatrics, Monash University, Melbourne, Victoria 3168, Australia.
Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria 3168, Australia.

Ina Rudloff (I)

Department of Paediatrics, Monash University, Melbourne, Victoria 3168, Australia.
Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria 3168, Australia.
ORCID: 0000-0002-7885-110X

Kirstin Elgass (K)

Monash Micro Imaging, Hudson Institute of Medical Research, Melbourne, Victoria 3168, Australia.
ORCID: 0000-0001-7747-2637

Jan Schröder (J)

Department of Anatomy and Developmental Biology, Monash University, Melbourne, Victoria 3800, Australia.
Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Victoria 3800, Australia.
Australian Regenerative Medicine Institute, Monash University, Melbourne, Victoria 3800, Australia.
ORCID: 0000-0001-5270-0605

Anton Maksimenko (A)

Imaging and Medical Beamline, Australian Synchrotron, Melbourne, Victoria 3168, Australia.
ORCID: 0000-0001-7543-6325

Niamh E Mangan (NE)

Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Melbourne, Victoria 3168, Australia.
Department of Molecular and Translational Science, Monash University, Melbourne, Victoria 3168, Australia.
ORCID: 0000-0003-3844-0709

Malcolm R Starkey (MR)

Priority Research Centres for Healthy Lungs and GrowUpWell, Hunter Medical Research Institute and University of Newcastle, Newcastle, New South Wales 2308, Australia.
Department of Immunology and Pathology, Monash University, Melbourne, Victoria 3004, Australia.
ORCID: 0000-0002-7359-7464

Elisabeth M Skuza (EM)

Department of Paediatrics, Monash University, Melbourne, Victoria 3168, Australia.
Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria 3168, Australia.

Yu B Y Sun (YBY)

Department of Anatomy and Developmental Biology, Monash University, Melbourne, Victoria 3800, Australia.
Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Victoria 3800, Australia.
Australian Regenerative Medicine Institute, Monash University, Melbourne, Victoria 3800, Australia.
ORCID: 0000-0003-0863-2769

Friederike Beker (F)

Mater Research Institute, University of Queensland, Brisbane, Queensland 4101, Australia.
Neonatal Services, Mercy Hospital for Women, Melbourne, Victoria 3084, Australia.
ORCID: 0000-0001-5688-2426

Clare L Collins (CL)

Neonatal Services, Mercy Hospital for Women, Melbourne, Victoria 3084, Australia.

Omar F Kamlin (OF)

Department of Newborn Research, Royal Women's Hospital, Melbourne, Victoria 3052, Australia.
University of Melbourne, Melbourne, Victoria 3010, Australia.
Murdoch Children's Research Institute, Melbourne, Victoria 3052, Australia.
ORCID: 0000-0002-4872-3860

Kai König (K)

Department of Paediatrics, Medicum Wesemlin, Lucerne 6006, Switzerland.

Atul Malhotra (A)

Department of Paediatrics, Monash University, Melbourne, Victoria 3168, Australia.
Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria 3168, Australia.
Monash Newborn, Monash Children's Hospital, Melbourne, Victoria 3168, Australia.
ORCID: 0000-0001-9664-4182

Kenneth Tan (K)

Department of Paediatrics, Monash University, Melbourne, Victoria 3168, Australia.
Monash Newborn, Monash Children's Hospital, Melbourne, Victoria 3168, Australia.
ORCID: 0000-0002-1931-0549

Christiane Theda (C)

Department of Newborn Research, Royal Women's Hospital, Melbourne, Victoria 3052, Australia.
University of Melbourne, Melbourne, Victoria 3010, Australia.
Murdoch Children's Research Institute, Melbourne, Victoria 3052, Australia.
ORCID: 0000-0001-7577-6004

Morag J Young (MJ)

Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Melbourne, Victoria 3168, Australia.
Baker Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia.

Catriona A McLean (CA)

Department of Anatomical Pathology, Alfred Health, Melbourne, Victoria 3004, Australia.
Department of Medicine, Central Clinical School, Monash University, Melbourne, Victoria 3800, Australia.
ORCID: 0000-0002-0302-5727

Nicholas J Wilson (NJ)

CSL Limited, Bio21 Institute, Parkville, Melbourne, Victoria 3052, Australia.

Arvind Sehgal (A)

Department of Paediatrics, Monash University, Melbourne, Victoria 3168, Australia.
Monash Newborn, Monash Children's Hospital, Melbourne, Victoria 3168, Australia.

Philip M Hansbro (PM)

Priority Research Centres for Healthy Lungs and GrowUpWell, Hunter Medical Research Institute and University of Newcastle, Newcastle, New South Wales 2308, Australia.
Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences, Ultimo, Sydney, New South Wales 2007, Australia.
ORCID: 0000-0002-4741-3035

James T Pearson (JT)

Cardiovascular Disease Program, Monash Biomedicine Discovery Institute and Department of Physiology, Monash University, Melbourne, Victoria 3800, Australia.
Department of Cardiac Physiology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka 564-8565, Japan.
Victorian Heart Institute, Melbourne, Victoria 3168, Australia.
ORCID: 0000-0002-3318-5406

Jose M Polo (JM)

Department of Anatomy and Developmental Biology, Monash University, Melbourne, Victoria 3800, Australia.
Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Victoria 3800, Australia.
Australian Regenerative Medicine Institute, Monash University, Melbourne, Victoria 3800, Australia.
Adelaide Centre for Epigenetics, University of Adelaide, Adelaide, South Australia 5005, Australia.
South Australian Immunogenomics Cancer Institute, University of Adelaide, Adelaide, South Australia 5005, Australia.
ORCID: 0000-0002-2531-778X

Alex Veldman (A)

Department of Paediatrics, Monash University, Melbourne, Victoria 3168, Australia.
Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria 3168, Australia.
Department of Pediatrics, Helios HSK, Wiesbaden 65199, Germany.
Department of Pediatric Cardiology, J. Liebig University, Gießen 35392, Germany.
ORCID: 0000-0003-4830-0857

Philip J Berger (PJ)

Department of Paediatrics, Monash University, Melbourne, Victoria 3168, Australia.
Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria 3168, Australia.

Claudia A Nold-Petry (CA)

Department of Paediatrics, Monash University, Melbourne, Victoria 3168, Australia.
Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria 3168, Australia.
ORCID: 0000-0002-7439-3834

Marcel F Nold (MF)

Department of Paediatrics, Monash University, Melbourne, Victoria 3168, Australia.
Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria 3168, Australia.
Monash Newborn, Monash Children's Hospital, Melbourne, Victoria 3168, Australia.
ORCID: 0000-0001-9682-4618

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Type 2 immune polarization is associated with...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies néonatales › Maladies du prématuré › Dysplasie bronchopulmonaire › Type 2 immune polarization is associated with...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Type 2 immune polarization is associated with...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › Type 2 immune polarization is associated with...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › Prématuré › Type 2 immune polarization is associated with...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Type 2 immune polarization is associated with...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-13 › Type 2 immune polarization is associated with...
questionsmedicales.fr › Appareil respiratoire › Poumon › Type 2 immune polarization is associated with...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Type 2 immune polarization is associated with...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Type 2 immune polarization is associated with...