Ketones regulate endothelial homeostasis.

Animals Diet, Ketogenic Endothelial Cells Heart Failure Homeostasis Ketone Bodies Ketones / pharmacology Mice

Journal

Cell metabolism
ISSN: 1932-7420
Titre abrégé: Cell Metab
Pays: United States
ID NLM: 101233170

Informations de publication

Date de publication:
05 04 2022
Historique:
entrez: 6 4 2022
pubmed: 7 4 2022
medline: 9 4 2022
Statut: ppublish

Résumé

In a recent paper in EMBO Molecular Medicine, Weis et al. reveal that cardiac endothelial cells can oxidize ketone bodies, which enhances cell proliferation, migration, and vessel sprouting. Furthermore, increasing ketone body levels with a ketogenic diet can increase endothelial cell proliferation and prevent blood vessel rarefication in hypertrophied mouse hearts. This suggests that increasing endothelial cell ketone oxidation has potential in treating heart failure.

Identifiants

DOI: 10.1016/j.cmet.2022.03.008 PMID: 35385704
pubmed: 35385704
pii: S1550-4131(22)00096-1
doi: 10.1016/j.cmet.2022.03.008
pii:
doi:

Substances chimiques

Ketone Bodies 0
Ketones 0

Types de publication

Journal Article Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

513-515

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests S.V. holds a Tier 1 Canada Research Chair in Cardiovascular Surgery and reports receiving research grants and/or speaking honoraria from Amarin, Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Eli Lilly, EOCI Pharmacomm Ltd, HLS Therapeutics, Janssen, Novartis, Novo Nordisk, Pfizer, PhaseBio, Sanofi, Sun Pharmaceuticals, and the Toronto Knowledge Translation Working Group. He is the President of the Canadian Medical and Surgical Knowledge Translation Research Group, a federally incorporated not-for-profit physician organization. G.D.L. reports receiving research grants and/or speaking honoraria from Applied Therapeutics, Boehringer Ingelheim, Servier, Janssen, Sanofi, and Novartis.

Auteurs

Gary D Lopaschuk (GD)

Cardiovascular Research Centre, Department of Pediatrics, University of Alberta, Edmonton, AB, Canada. Electronic address: gary.lopaschuk@ualberta.ca.

David A Hess (DA)

Robarts Research Institute, University of Western Ontario, London, ON, Canada.

Subodh Verma (S)

Division of Cardiac Surgery, Li Ka Shing Knowledge Institute of St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Ketones regulate endothelial homeostasis.
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › Régime pauvre en glucides › Régime cétogène › Ketones regulate endothelial homeostasis.
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Ketones regulate endothelial homeostasis.
questionsmedicales.fr › Maladies cardiovasculaires › Cardiopathies › Défaillance cardiaque › Ketones regulate endothelial homeostasis.
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › Ketones regulate endothelial homeostasis.
questionsmedicales.fr › Composés chimiques organiques › Cétones › Corps cétoniques › Ketones regulate endothelial homeostasis.
questionsmedicales.fr › Composés chimiques organiques › Cétones › Ketones regulate endothelial homeostasis.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Ketones regulate endothelial homeostasis.