Biallelic, Selectable, Knock-in Targeting of CCR5
CCR5
CRISPR-Cas9
biallelic mutations
co-receptor of human immunodeficiency virus type 1 (HIV-1),adipose-derived stem cells (ASCs)
homology directed repair (HDR)
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
23
11
2021
accepted:
22
02
2022
entrez:
7
4
2022
pubmed:
8
4
2022
medline:
9
4
2022
Statut:
epublish
Résumé
Transplanting HIV-1 positive patients with hematopoietic stem cells homozygous for a 32 bp deletion in the chemokine receptor type 5 (CCR5) gene resulted in a loss of detectable HIV-1, suggesting genetically disrupting CCR5 is a promising approach for HIV-1 cure. Targeting the CCR5-locus with CRISPR-Cas9 was shown to decrease the amount of CCR5 expression and HIV-1 susceptibility
Identifiants
pubmed: 35386712
doi: 10.3389/fimmu.2022.821190
pmc: PMC8978527
doi:
Substances chimiques
CCR5 protein, human
0
Receptors, CCR5
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
821190Informations de copyright
Copyright © 2022 Scheller, Rashad, Saleh, Willingham, Reilich, Lin, Izadpanah, Alt and Braun.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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