In-Depth Immunophenotyping With Mass Cytometry During TB Treatment Reveals New T-Cell Subsets Associated With Culture Conversion.
T-cell
immunomonitoring
mass cytometry (CyTOF)
tuberculosis
unsupervised analysis
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
12
01
2022
accepted:
22
02
2022
entrez:
8
4
2022
pubmed:
9
4
2022
medline:
12
4
2022
Statut:
epublish
Résumé
Tuberculosis (TB) is a difficult-to-treat infection because of multidrug regimen requirements based on drug susceptibility profiles and treatment observance issues. TB cure is defined by mycobacterial sterilization, technically complex to systematically assess. We hypothesized that microbiological outcome was associated with stage-specific immune changes in peripheral whole blood during TB treatment. The T-cell phenotypes of treated TB patients were prospectively characterized in a blinded fashion using mass cytometry after
Identifiants
pubmed: 35392094
doi: 10.3389/fimmu.2022.853572
pmc: PMC8980213
doi:
Substances chimiques
Antigens, Bacterial
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
853572Subventions
Organisme : FIC NIH HHS
ID : D43 TW007124
Pays : United States
Informations de copyright
Copyright © 2022 Chedid, Andrieu, Kokhreidze, Tukvadze, Biswas, Ather, Uddin, Banu, De Maio, Delogu, Endtz, Goletti, Vocanson, Dumitrescu, Hoffmann and Ader.
Déclaration de conflit d'intérêts
DG reports personal fees from Biomérieux (consulting), Qiagen (consulting, lectures), and Diasorin (lectures) outside the submitted work. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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