Shapes of subcortical structures in adolescents with and without familial history of substance use disorder.
MRI
adolescents
familial risk for SUD
shape analysis
subcortical brain structures
substance use disorder (SUD)
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
15 06 2022
15 06 2022
Historique:
revised:
24
01
2022
received:
04
11
2021
accepted:
26
01
2022
pubmed:
9
4
2022
medline:
24
5
2022
entrez:
8
4
2022
Statut:
ppublish
Résumé
It has been suggested that intergenerational transmission of risk for substance use disorder (SUD) manifests in the brain anatomy of substance naïve adolescents. While volume and shapes of subcortical structures (SSS) have been shown to be heritable, these structures, especially the pallidum, putamen, nucleus accumbens, and hippocampus, have also been associated with substance use disorders. However, it is not clear if those anatomical differences precede substance use or are the result of that use. Therefore, we examined if volume and SSS of adolescents with a family history (FH+) of SUD differed from adolescents without such a history (FH-). Because risk for SUD is associated with anxiety and impulsivity, we also examined correlations between these psychological characteristics and volume/SSS. Using structural MRI and FSL software, we segmented subcortical structures and obtained indices of SSS and volumes of 64 FH+ and 58 FH- adolescents. We examined group differences in volume and SSS, and the correlations between volume/SSS and trait anxiety and impulsivity. FH+ adolescents had a significant inward deformation in the shape of the right anterior hippocampus compared to FH- adolescents, while the volume of this structure did not differ between groups. Neither shape nor volume of the other subcortical structures differed between groups. In the FH+ adolescents, the left hippocampus shape was positively correlated with both trait anxiety and impulsivity, while in FH- adolescents a negative correlation pattern of SSS was seen in the hippocampus. SSS appears to capture local anatomical features that traditional volumetric analysis does not. The inward shape deformation in the right anterior hippocampus in FH+ adolescents may be related to the known increased risk for behavioral dysregulation leading to SUD in FH+ offspring. Hippocampus shape also exhibits opposite patterns of correlation with anxiety and impulsivity scores across the FH+ and FH- adolescents. These novel findings may reveal neural correlates, not captured by traditional volumetric analysis, of familial transmission of increased vulnerability to SUD.
Identifiants
pubmed: 35393707
doi: 10.1002/hbm.25804
pmc: PMC9120549
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2759-2770Subventions
Organisme : NIDA NIH HHS
ID : R01 DA038154
Pays : United States
Informations de copyright
© 2022 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
Références
Eur Neuropsychopharmacol. 2013 Apr;23(4):276-84
pubmed: 22739126
Neuroimage Clin. 2018 Jul 24;20:243-251
pubmed: 30094172
Psychiatry Res Neuroimaging. 2017 Oct 30;268:22-26
pubmed: 28843088
J Genet Psychol. 2007 Dec;168(4):465-9
pubmed: 18232522
JAMA Pediatr. 2020 Nov 1;174(11):1073-1081
pubmed: 32986124
Nat Genet. 2019 Nov;51(11):1624-1636
pubmed: 31636452
Psychiatr Times. 2008 Oct;25(10):19-23
pubmed: 20640182
Neuroimage Clin. 2013 Jul 11;3:47-53
pubmed: 24179848
PLoS One. 2016 Apr 06;11(4):e0152983
pubmed: 27049765
Am J Psychiatry. 2001 Nov;158(11):1783-93
pubmed: 11691682
Nature. 2015 Apr 9;520(7546):224-9
pubmed: 25607358
Neuroimage. 2019 Jan 15;185:35-57
pubmed: 30291974
Arch Gen Psychiatry. 1998 Nov;55(11):973-9
pubmed: 9819065
J Stud Alcohol Drugs. 2015 Jan;76(1):47-56
pubmed: 25486393
Drug Alcohol Depend. 2019 Sep 1;202:191-199
pubmed: 31357120
Hum Brain Mapp. 2022 Jun 15;43(9):2759-2770
pubmed: 35393707
Neuroimage. 2009 Jan 1;44(1):83-98
pubmed: 18501637
Psychiatry Res. 2004 Dec 30;132(3):209-18
pubmed: 15664792
Biol Psychiatry. 2003 Dec 1;54(11):1234-40
pubmed: 14643091
Soc Work Public Health. 2013;28(3-4):407-23
pubmed: 23731428
Arthritis Care Res (Hoboken). 2011 Nov;63 Suppl 11:S467-72
pubmed: 22588767
J Am Acad Child Adolesc Psychiatry. 2013 May;52(5):527-536.e2
pubmed: 23622854
Neuroimage. 2009 Oct 1;47(4):1476-86
pubmed: 19463957
Front Neuroendocrinol. 2018 Apr;49:106-113
pubmed: 29421158
Eur Arch Psychiatry Clin Neurosci. 2015 Dec;265(8):637-45
pubmed: 25467383
Hum Brain Mapp. 2015 Dec;36(12):5018-37
pubmed: 26350954
Neuropsychopharmacology. 2010 Jan;35(1):27-47
pubmed: 19675534
Front Hum Neurosci. 2015 Apr 22;9:219
pubmed: 25954186
Hum Brain Mapp. 2010 Mar;31(3):438-47
pubmed: 19718651
Front Behav Neurosci. 2019 Sep 19;13:192
pubmed: 31680889
Front Psychiatry. 2018 May 03;9:175
pubmed: 29773998
Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 Apr;5(4):392-402
pubmed: 32115373
Nat Commun. 2016 Dec 15;7:13738
pubmed: 27976715
J Clin Psychol. 1995 Nov;51(6):768-74
pubmed: 8778124
Addict Biol. 2020 Nov;25(6):e12830
pubmed: 31746534
Psychiatry Res. 2002 Aug 20;115(1-2):15-35
pubmed: 12165365
Neuroimage. 2011 Jun 1;56(3):907-22
pubmed: 21352927
Neuroimage. 2011 May 1;56(1):212-9
pubmed: 21272654
Arch Gen Psychiatry. 1988 Dec;45(12):1069-77
pubmed: 2848472
Am J Drug Alcohol Abuse. 2015;41(5):414-24
pubmed: 26337200
Schizophr Res. 2013 Jan;143(1):179-84
pubmed: 23201308
Addiction. 2008 Jul;103(7):1198-205
pubmed: 18494839
Dev Cogn Neurosci. 2021 Apr;48:100942
pubmed: 33751954
Hippocampus. 1998;8(6):608-19
pubmed: 9882018
Nat Rev Neurosci. 2014 Oct;15(10):655-69
pubmed: 25234264
Psychol Addict Behav. 2009 Jun;23(2):315-28
pubmed: 19586148
Alcohol Clin Exp Res. 2018 Jan;42(1):89-99
pubmed: 29105114