An integrated intervention combining cognitive-behavioural stress management and progressive muscle relaxation improves immune biomarkers and reduces COVID-19 severity and progression in patients with COVID-19: A randomized control trial.
COVID-19
COVID-19 progression
COVID-19 severity
immune biomarkers
relaxation protocol
Journal
Stress and health : journal of the International Society for the Investigation of Stress
ISSN: 1532-2998
Titre abrégé: Stress Health
Pays: England
ID NLM: 101089166
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
revised:
26
03
2022
received:
22
08
2021
accepted:
04
04
2022
pubmed:
9
4
2022
medline:
16
12
2022
entrez:
8
4
2022
Statut:
ppublish
Résumé
COVID-19 is a world disaster. In response to COVID-19 quarantine, stress, anxiety, and depression may easily develop which negatively affect immunity and decrease the patient's response against the COVID-19 virus. This study investigated the effect of an integrated intervention combining cognitive-behavioural stress management (CBSM) and progressive muscle relaxation (PMRs) on immune biomarkers and disease severity and progression in patients with COVID-19 and the period to which these changes last. Thirty patients with mild or moderate COVID-19 were randomly distributed into intervention and control groups. The intervention group performed an integrated intervention combining CBSM and PMRs. There were three outcome measures including blood immune markers, salivary immunoglobulin A, and Wisconsin scale (WIS). Two-week post-intervention, there were significant differences between groups in the WIS total score, Leucocytes, Lymphocytes, Interleukin-6, and Immunoglobulin-A. While there were non-significant differences between both groups in Interleukin-10 and TNF-α. The significant differences between groups in the WIS total score, Leucocytes, Lymphocytes, Interleukin-6, and Immunoglobulin-A significantly continued 1 week as a follow-up. This study concluded that performing an integrated intervention combining CBSM and PMRs for 2 weeks significantly increases immune biomarkers mainly Leucocytes, Lymphocytes, Interleukin-10, and Interleukin-6 along with S-IgA. Also, this protocol significantly decreases disease severity and associated stress, anxiety, and depression; and enhances the quality of life in patients with COVID-19. The study was retrospectively registered with NCT04998708.
Identifiants
pubmed: 35393715
doi: 10.1002/smi.3151
pmc: PMC9111066
doi:
Substances chimiques
Biomarkers
0
Interleukin-10
130068-27-8
Interleukin-6
0
Immunoglobulin A
0
Banques de données
ClinicalTrials.gov
['NCT04998708']
Types de publication
Randomized Controlled Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
978-988Informations de copyright
© 2022 John Wiley & Sons Ltd.
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