NT3 treatment alters spinal cord injury-induced changes in the gray matter volume of rhesus monkey cortex.

Animals Brain Gray Matter / diagnostic imaging Macaca mulatta Magnetic Resonance Imaging Neuralgia Spinal Cord Injuries

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
08 04 2022
Historique:
received: 17 02 2022
accepted: 01 04 2022
entrez: 9 4 2022
pubmed: 10 4 2022
medline: 13 4 2022
Statut: epublish

Résumé

Spinal cord injury (SCI) may cause structural alterations in brain due to pathophysiological processes, but the effects of SCI treatment on brain have rarely been reported. Here, voxel-based morphometry is employed to investigate the effects of SCI and neurotrophin-3 (NT3) coupled chitosan-induced regeneration on brain and spinal cord structures in rhesus monkeys. Possible association between brain and spinal cord structural alterations is explored. The pain sensitivity and stepping ability of animals are collected to evaluate sensorimotor functional alterations. Compared with SCI, the unique effects of NT3 treatment on brain structure appear in extensive regions which involved in motor control and neuropathic pain, such as right visual cortex, superior parietal lobule, left superior frontal gyrus (SFG), middle frontal gyrus, inferior frontal gyrus, insula, secondary somatosensory cortex, anterior cingulate cortex, and bilateral caudate nucleus. Particularly, the structure of insula is significantly correlated with the pain sensitivity. Regenerative treatment also shows a protective effect on spinal cord structure. The associations between brain and spinal cord structural alterations are observed in right primary somatosensory cortex, SFG, and other regions. These results help further elucidate secondary effects on brain of SCI and provide a basis for evaluating the effects of NT3 treatment on brain structure.

Identifiants

DOI: 10.1038/s41598-022-09981-5 PMID: 35396344 PMC: PMC8993853
pubmed: 35396344
doi: 10.1038/s41598-022-09981-5
pii: 10.1038/s41598-022-09981-5
pmc: PMC8993853
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

5919

Informations de copyright

© 2022. The Author(s).

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Auteurs

Shu-Sheng Bao (SS)

Beijing Key Laboratory for Biomaterials and Neural Regeneration, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China.

Can Zhao (C)

Institute of Rehabilitation Engineering, China Rehabilitation Science Institute, Beijing, 100068, China. zhaocan05@163.com.
School of Rehabilitation, Capital Medical University, Beijing, 100068, China. zhaocan05@163.com.

Hao-Wei Chen (HW)

Beijing Key Laboratory for Biomaterials and Neural Regeneration, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China.

Ting Feng (T)

Beijing Key Laboratory for Biomaterials and Neural Regeneration, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China.

Xiao-Jun Guo (XJ)

Beijing Key Laboratory for Biomaterials and Neural Regeneration, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China.

Meng Xu (M)

Department of Orthopedics, The First Medical Center of PLA General Hospital, Beijing, 100853, China. drxm301@163.com.

Jia-Sheng Rao (JS)

Beijing Key Laboratory for Biomaterials and Neural Regeneration, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China. raojschina@126.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › NT3 treatment alters spinal cord...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › NT3 treatment alters spinal cord...
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › Substance grise › NT3 treatment alters spinal cord...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca › Macaca mulatta › NT3 treatment alters spinal cord...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › NT3 treatment alters spinal cord...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Névralgie › NT3 treatment alters spinal cord...
questionsmedicales.fr › Plaies et blessures › Traumatismes de la moelle épinière › NT3 treatment alters spinal cord...