Rare sudden unexpected death in epilepsy SCN5A variants cause changes in channel function implicating cardiac arrhythmia as a cause of death.
SUDEP
cardiac arrhythmia
epilepsy
genetics
ion channels
Journal
Epilepsia
ISSN: 1528-1167
Titre abrégé: Epilepsia
Pays: United States
ID NLM: 2983306R
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
revised:
06
04
2022
received:
25
11
2021
accepted:
07
04
2022
pubmed:
10
4
2022
medline:
7
6
2022
entrez:
9
4
2022
Statut:
ppublish
Résumé
Sudden unexpected death in epilepsy (SUDEP) is a leading cause of premature death in epilepsy. The underlying pathological mechanisms are likely to be multifactorial. Cardiac arrhythmia has been suggested as a cause of death in some patients with SUDEP. SCN5A encodes the cardiac Na
Substances chimiques
Anticonvulsants
0
NAV1.5 Voltage-Gated Sodium Channel
0
SCN5A protein, human
0
Lamotrigine
U3H27498KS
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e57-e62Informations de copyright
© 2022 International League Against Epilepsy.
Références
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