Nitrate consumption preserves HFD-induced skeletal muscle mitochondrial ADP sensitivity and lysine acetylation: A potential role for SIRT1.

AMP-Activated Protein Kinases / genetics Acetylation Adenosine Diphosphate / metabolism Animals Diet, High-Fat / adverse effects Glucose / metabolism Insulin / metabolism Insulin Resistance Lysine / metabolism Mice Mice, Inbred C57BL Muscle, Skeletal / metabolism Nitrates / metabolism Proto-Oncogene Proteins c-akt / metabolism Sirtuin 1 / genetics

Insulin resistance Mitochondrial dysfunction Nitrate Obesity SIRT1

Journal

Redox biology

ISSN: 2213-2317

Titre abrégé: Redox Biol

Pays: Netherlands

ID NLM: 101605639

Informations de publication

Date de publication:
06 2022

Historique:

received: 12 03 2022

accepted: 28 03 2022

pubmed: 11 4 2022

medline: 11 5 2022

entrez: 10 4 2022

Statut: ppublish

Résumé

Dietary nitrate supplementation, and the subsequent serial reduction to nitric oxide, has been shown to improve glucose homeostasis in several pre-clinical models of obesity and insulin resistance. While the mechanisms remain poorly defined, the beneficial effects of nitrate appear to be partially dependent on AMPK-mediated signaling events, a central regulator of metabolism and mitochondrial bioenergetics. Since AMPK can activate SIRT1, we aimed to determine if nitrate supplementation (4 mM sodium nitrate via drinking water) improved skeletal muscle mitochondrial bioenergetics and acetylation status in mice fed a high-fat diet (HFD: 60% fat). Consumption of HFD induced whole-body glucose intolerance, and within muscle attenuated insulin-induced Akt phosphorylation, mitochondrial ADP sensitivity (higher apparent K

Identifiants

DOI: 10.1016/j.redox.2022.102307 PMID: 35398714 PMC: PMC9006675

pubmed: 35398714

pii: S2213-2317(22)00079-9

doi: 10.1016/j.redox.2022.102307

pmc: PMC9006675

pii:

doi:

Substances chimiques

Insulin 0

Nitrates 0

Adenosine Diphosphate 61D2G4IYVH

Proto-Oncogene Proteins c-akt EC 2.7.11.1

AMP-Activated Protein Kinases EC 2.7.11.31

Sirt1 protein, mouse EC 3.5.1.-

Sirtuin 1 EC 3.5.1.-

Glucose IY9XDZ35W2

Lysine K3Z4F929H6

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

102307

Nitrate consumption preserves HFD-induced skeletal muscle mitochondrial ADP sensitivity and lysine acetylation: A potential role for SIRT1.

Journal

Informations de publication

Résumé

Identifiants

Substances chimiques

Types de publication

Langues

Sous-ensembles de citation

Pagination

Informations de copyright

Auteurs

Henver S Brunetta (HS)

Heather L Petrick (HL)

Iman Momken (I)

Rachel M Handy (RM)

Christopher Pignanelli (C)

Everson A Nunes (EA)

Jérôme Piquereau (J)

Mathias Mericskay (M)

Graham P Holloway (GP)

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Classifications MeSH