Oncogene Convergence in Extrachromosomal DNA Hubs.
Journal
Cancer discovery
ISSN: 2159-8290
Titre abrégé: Cancer Discov
Pays: United States
ID NLM: 101561693
Informations de publication
Date de publication:
02 05 2022
02 05 2022
Historique:
received:
19
01
2022
revised:
28
02
2022
accepted:
04
03
2022
pubmed:
11
4
2022
medline:
4
5
2022
entrez:
10
4
2022
Statut:
ppublish
Résumé
Extrachromosomal DNA circles (ecDNA) are a common mechanism for oncogene amplification and are associated with worse clinical outcomes compared with other types of oncogene amplification. Several recent discoveries of ecDNA hubs-local congregations of ecDNAs in the nucleus-highlight unique features of ecDNA biology that may contribute to higher oncogene expression and rapid tumor evolution.
Identifiants
pubmed: 35398879
pii: 694090
doi: 10.1158/2159-8290.CD-22-0076
pmc: PMC9302380
mid: NIHMS1807954
doi:
Substances chimiques
DNA
9007-49-2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1195-1198Subventions
Organisme : NHGRI NIH HHS
ID : P50 HG007735
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA209919
Pays : United States
Organisme : NHGRI NIH HHS
ID : RM1 HG007735
Pays : United States
Informations de copyright
©2022 The Authors; Published by the American Association for Cancer Research.
Références
Genes Chromosomes Cancer. 2020 Mar;59(3):133-143
pubmed: 31569279
Nature. 2021 Mar;591(7848):137-141
pubmed: 33361815
Lancet. 1965 Jul 10;1(7402):55-8
pubmed: 14304929
Nat Methods. 2016 Nov;13(11):919-922
pubmed: 27643841
Annu Rev Pathol. 2022 Jan 24;17:367-386
pubmed: 34752712
Genes Chromosomes Cancer. 2007 Oct;46(10):865-74
pubmed: 17616968
Cell. 2019 Nov 27;179(6):1330-1341.e13
pubmed: 31761532
Nature. 2021 Dec;600(7890):731-736
pubmed: 34819668
Cancer Cell. 2021 May 10;39(5):694-707.e7
pubmed: 33836152
Nat Genet. 2020 Sep;52(9):891-897
pubmed: 32807987
Nature. 2022 Feb;602(7897):510-517
pubmed: 35140399
Nat Genet. 2021 Dec;53(12):1673-1685
pubmed: 34782764
Cancer Discov. 2022 Feb;12(2):468-483
pubmed: 34819316
Nature. 2019 Nov;575(7784):699-703
pubmed: 31748743
Science. 2014 Jan 3;343(6166):72-6
pubmed: 24310612
Cell. 2013 Apr 11;153(2):320-34
pubmed: 23582323
J Neurosurg. 1965 Feb;22:160-8
pubmed: 14291674
Nature. 2017 Mar 2;543(7643):122-125
pubmed: 28178237