Ultra-high dose rate radiation production and delivery systems intended for FLASH.
FLASH
UHDR
conformal
dose rate
electron
proton
Journal
Medical physics
ISSN: 2473-4209
Titre abrégé: Med Phys
Pays: United States
ID NLM: 0425746
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
revised:
21
02
2022
received:
23
10
2021
accepted:
15
03
2022
pubmed:
12
4
2022
medline:
20
7
2022
entrez:
11
4
2022
Statut:
ppublish
Résumé
Higher dose rates, a trend for radiotherapy machines, can be beneficial in shortening treatment times for radiosurgery and mitigating the effects of motion. Recently, even higher doses (e.g., 100 times greater) have become targeted because of their potential to generate the FLASH effect (FE). We refer to these physical dose rates as ultra-high (UHDR). The complete relationship between UHDR and the FE is unknown. But UHDR systems are needed to explore the relationship further and to deliver clinical UHDR treatments, where indicated. Despite the challenging set of unknowns, the authors seek to make reasonable assumptions to probe how existing and developing technology can address the UHDR conditions needed to provide beam generation capable of producing the FE in preclinical and clinical applications. As a preface, this paper discusses the known and unknown relationships between UHDR and the FE. Based on these, different accelerator and ionizing radiation types are then discussed regarding the relevant UHDR needs. The details of UHDR beam production are discussed for existing and potential future systems such as linacs, cyclotrons, synchrotrons, synchrocyclotrons, and laser accelerators. In addition, various UHDR delivery mechanisms are discussed, along with required developments in beam diagnostics and dose control systems.
Identifiants
pubmed: 35403262
doi: 10.1002/mp.15659
pmc: PMC9544515
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4875-4911Informations de copyright
© 2022 The Authors. Medical Physics published by Wiley Periodicals LLC on behalf of American Association of Physicists in Medicine.
Références
Med Phys. 2021 Jun;48(6):3134-3142
pubmed: 33866565
Med Phys. 2018 Feb;45(2):863-874
pubmed: 29206287
Med Phys. 2013 Jul;40(7):072101
pubmed: 23822445
Int J Radiat Oncol Biol Phys. 2017 Jan 1;97(1):195-203
pubmed: 27816362
Int J Radiat Oncol Biol Phys. 2021 Jul 1;110(3):872-882
pubmed: 33444695
Med Phys. 2020 Sep;47(9):4348-4355
pubmed: 32452558
Int J Radiat Oncol Biol Phys. 2020 Feb 1;106(2):440-448
pubmed: 31928642
Med Phys. 2017 Jun;44(6):2544-2555
pubmed: 28339108
Med Phys. 2017 Mar;44(3):1157-1167
pubmed: 28094853
Int J Radiat Oncol Biol Phys. 2020 Mar 1;106(3):621-629
pubmed: 31759074
Med Phys. 1977 Jul-Aug;4(4):297-301
pubmed: 407436
Radiat Res. 2020 Dec 1;194(6):618-624
pubmed: 32853385
Med Phys. 2022 Jul;49(7):4875-4911
pubmed: 35403262
Phys Med Biol. 2014 Sep 7;59(17):4961-71
pubmed: 25109620
Med Phys. 2020 Jul;47(7):3243-3249
pubmed: 32279337
Phys Med Biol. 2002 Jul 7;47(13):2247-61
pubmed: 12164585
Med Phys. 2021 Feb;48(2):819-830
pubmed: 33251606
Nature. 2004 Sep 30;431(7008):538-41
pubmed: 15457252
Acta Radiol Ther Phys Biol. 1977 Apr;16(2):145-56
pubmed: 405843
Med Phys. 2001 Jul;28(7):1427-30
pubmed: 11488574
Med Phys. 2012 Jun;39(6):3501-8
pubmed: 22755730
Phys Med Biol. 2002 Apr 21;47(8):1285-301
pubmed: 12030556
Phys Med Biol. 2017 Aug 11;62(17):7075-7096
pubmed: 28741595
Sci Transl Med. 2014 Jul 16;6(245):245ra93
pubmed: 25031268
Radiat Res. 2020 Dec 1;194(6):636-645
pubmed: 32853387
Front Oncol. 2020 Jan 17;9:1563
pubmed: 32010633
Radiother Oncol. 2018 Dec;129(3):582-588
pubmed: 30177374
Nature. 2004 Sep 30;431(7008):535-8
pubmed: 15457251
Int J Radiat Biol Relat Stud Phys Chem Med. 1971;19(5):479-83
pubmed: 5314348
Phys Med. 2019 Apr;60:50-57
pubmed: 31000086
Phys Med Biol. 2009 Jun 7;54(11):3315-28
pubmed: 19430107
Int J Radiat Biol Relat Stud Phys Chem Med. 1974 Sep;26(3):259-67
pubmed: 4547756
J Appl Clin Med Phys. 2015 May 08;16(3):5219
pubmed: 26103482
Phys Med. 2015 Jun;31(4):322-32
pubmed: 25812487
Med Phys. 2014 Jun;41(6):061713
pubmed: 24877808
Med Phys. 2022 Mar;49(3):1972-1973
pubmed: 35262219
Med Phys. 2000 Apr;27(4):716-24
pubmed: 10798694
Science. 2002 Nov 22;298(5598):1596-600
pubmed: 12446903
Phys Med. 2020 Oct;78:101-108
pubmed: 32956916
Radiat Res. 2020 Dec 1;194(6):571-572
pubmed: 32853355
Phys Med Biol. 2021 Feb 24;66(5):055018
pubmed: 33498040
Radiother Oncol. 2019 Oct;139:18-22
pubmed: 31303340
Phys Med Biol. 2019 Aug 28;64(17):175007
pubmed: 31272087
Cancers (Basel). 2021 Mar 01;13(5):
pubmed: 33804336
Radiat Res. 2020 Dec 1;194(6):656-664
pubmed: 32991708
Med Phys. 2020 Dec;47(12):6396-6404
pubmed: 32910460
Med Phys. 2021 Aug;48(8):4472-4484
pubmed: 34077590
Phys Med Biol. 2000 Jul;45(7):1781-805
pubmed: 10943919
Med Phys. 2020 Dec;47(12):6388-6395
pubmed: 33068294
Sci Rep. 2020 Dec 10;10(1):21600
pubmed: 33303827
Phys Med Biol. 2003 Nov 21;48(22):N301-12
pubmed: 14680273
Radiother Oncol. 2017 Sep;124(3):365-369
pubmed: 28545957
Radiother Oncol. 2019 Oct;139:40-45
pubmed: 30755324
Nature. 2006 Dec 7;444(7120):737-9
pubmed: 17151663
J Radiat Res. 2013 Jul;54 Suppl 1:i155-61
pubmed: 23824121
Int J Radiat Biol Relat Stud Phys Chem Med. 1982 Dec;42(6):611-20
pubmed: 6984434
Acta Oncol. 2019 Oct;58(10):1463-1469
pubmed: 31241377
Clin Cancer Res. 2019 Jan 1;25(1):35-42
pubmed: 29875213
Med Phys. 2012 May;39(5):2559-68
pubmed: 22559626
Med Phys. 2006 Jan;33(1):155-62
pubmed: 16485422
Cancers (Basel). 2020 Jun 24;12(6):
pubmed: 32599789
Med Phys. 2021 Jan;48(1):e1-e30
pubmed: 33078858
Nature. 2004 Sep 30;431(7008):541-4
pubmed: 15457253
Phys Med Biol. 2021 Jan 30;66(3):03NT01
pubmed: 33296881
Radiat Res. 2020 Dec 1;194(6):625-635
pubmed: 33348373
Radiother Oncol. 2019 Oct;139:4-10
pubmed: 31253467
Phys Med Biol. 2009 Oct 7;54(19):5831-46
pubmed: 19741273
Med Phys. 2018 Nov;45(11):e953-e983
pubmed: 30421804
Clin Cancer Res. 2020 Mar 15;26(6):1497-1506
pubmed: 31796518