Blocking function of allergen-specific immunoglobulin G, F(ab')
Journal
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
ISSN: 1534-4436
Titre abrégé: Ann Allergy Asthma Immunol
Pays: United States
ID NLM: 9503580
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
13
01
2022
revised:
10
03
2022
accepted:
16
03
2022
pubmed:
12
4
2022
medline:
31
5
2022
entrez:
11
4
2022
Statut:
ppublish
Résumé
The blocking function of allergen-specific F(ab') To investigate the inhibitory function of sIgG, sF(ab') This study involved 10 subjects (aged 18-42 years) with house dust mite allergic rhinitis or asthma who received a 156-week course of Der-p SCIT. Total IgG levels were purified from the serum of the participants at weeks 0 and 156 by protein A affinity chromatography. Der-p sIgG was purified by affinity chromatography with Der-p as a ligand at week 156. The sF(ab') We found that the Der-p sIgG, sF(ab') SCIT-induced Der-p sIgG, sF(ab') This study was approved by the Ethics Committee of the First Affiliated Hospital of Guangzhou Medical University and registered in the Chinese Clinical Trial Registry (ChiCTR-OOC-15006207, https://www.chictr.org.cn/enindex.aspx).
Sections du résumé
BACKGROUND
The blocking function of allergen-specific F(ab')
OBJECTIVE
To investigate the inhibitory function of sIgG, sF(ab')
METHODS
This study involved 10 subjects (aged 18-42 years) with house dust mite allergic rhinitis or asthma who received a 156-week course of Der-p SCIT. Total IgG levels were purified from the serum of the participants at weeks 0 and 156 by protein A affinity chromatography. Der-p sIgG was purified by affinity chromatography with Der-p as a ligand at week 156. The sF(ab')
RESULTS
We found that the Der-p sIgG, sF(ab')
CONCLUSION
SCIT-induced Der-p sIgG, sF(ab')
CLINICAL TRIAL REGISTRATION
This study was approved by the Ethics Committee of the First Affiliated Hospital of Guangzhou Medical University and registered in the Chinese Clinical Trial Registry (ChiCTR-OOC-15006207, https://www.chictr.org.cn/enindex.aspx).
Identifiants
pubmed: 35405358
pii: S1081-1206(22)00293-9
doi: 10.1016/j.anai.2022.03.031
pii:
doi:
Substances chimiques
Allergens
0
Antigens, Dermatophagoides
0
Arthropod Proteins
0
Immunoglobulin G
0
Immunologic Factors
0
Immunoglobulin E
37341-29-0
Banques de données
ChiCTR
['ChiCTR-OOC-15006207']
Types de publication
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
689-696Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.