Omega-3/Omega-6 Long-Chain Fatty Acid Imbalance in Phase I Retinopathy of Prematurity.
LCPUFA
adiponectin
hyperglycemia
retinal neuron
retinal vessel
retinopathy of prematurity
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
23 Mar 2022
23 Mar 2022
Historique:
received:
29
01
2022
revised:
17
03
2022
accepted:
21
03
2022
entrez:
12
4
2022
pubmed:
13
4
2022
medline:
14
4
2022
Statut:
epublish
Résumé
There is a gap in understanding the effect of the essential ω-3 and ω-6 long-chain polyunsaturated fatty acids (LCPUFA) on Phase I retinopathy of prematurity (ROP), which precipitates proliferative ROP. Postnatal hyperglycemia contributes to Phase I ROP by delaying retinal vascularization. In mouse neonates with hyperglycemia-associated Phase I retinopathy, dietary ω-3 (vs. ω-6 LCPUFA) supplementation promoted retinal vessel development. However, ω-6 (vs. ω-3 LCPUFA) was also developmentally essential, promoting neuronal growth and metabolism as suggested by a strong metabolic shift in almost all types of retinal neuronal and glial cells identified with single-cell transcriptomics. Loss of adiponectin (APN) in mice (mimicking the low APN levels in Phase I ROP) decreased LCPUFA levels (including ω-3 and ω-6) in retinas under normoglycemic and hyperglycemic conditions. ω-3 (vs. ω-6) LCPUFA activated the APN pathway by increasing the circulating APN levels and inducing expression of the retinal APN receptor. Our findings suggested that both ω-3 and ω-6 LCPUFA are crucial in protecting against retinal neurovascular dysfunction in a Phase I ROP model; adequate ω-6 LCPUFA levels must be maintained in addition to ω-3 supplementation to prevent retinopathy. Activation of the APN pathway may further enhance the ω-3 and ω-6 LCPUFA's protection against ROP.
Identifiants
pubmed: 35405946
pii: nu14071333
doi: 10.3390/nu14071333
pmc: PMC9002570
pii:
doi:
Substances chimiques
Adiponectin
0
Fatty Acids, Omega-3
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Institute of Health
ID : R01EY032492
Organisme : National Institute of Health
ID : R01EY017017
Organisme : Boston Children's Hospital
ID : 1U54HD090255
Organisme : NEI NIH HHS
ID : R01 EY017017
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD105351
Pays : United States
Organisme : National Institute of Health
ID : R01EY030904
Organisme : National Institute of Health
ID : R01EY01717-13S1
Organisme : Massachusetts Lions Eye Research Fund
ID : 87820
Organisme : NEI NIH HHS
ID : R01 EY030904
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY032492
Pays : United States
Organisme : Boston Children's Hospital
ID : 92214
Organisme : Boston Children's Hospital
ID : 97906
Organisme : NICHD NIH HHS
ID : U54 HD090255
Pays : United States
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