Does Inflammation Contribute to Cancer Incidence and Mortality during Aging? A Conceptual Review.
aging
biomarkers
cancer
cell senescence
inflammation
older persons
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
23 Mar 2022
23 Mar 2022
Historique:
received:
15
01
2022
revised:
11
03
2022
accepted:
19
03
2022
entrez:
12
4
2022
pubmed:
13
4
2022
medline:
13
4
2022
Statut:
epublish
Résumé
Aging is associated with chronic low-grade inflammation, cancer incidence and mortality. As inflammation contributes to cancer initiation and progression, one could hypothesize that age-associated chronic low-grade inflammation contributes to the increase in cancer incidence and/or mortality observed during aging. Here, we review the evidence supporting this hypothesis: (1) epidemiological associations between biomarkers of systemic inflammation and cancer incidence and mortality in older people, (2) therapeutic clues suggesting that targeting inflammation could reduce cancer incidence and mortality and (3) experimental evidence from animal models highlighting inflammation as a link between various mechanisms of aging and cancer initiation and progression. Despite a large body of literature linking aging, inflammation and cancer, convincing evidence for the clear implication of specific inflammatory pathways explaining cancer incidence or mortality during aging is still lacking. Further dedicated research is needed to fill these gaps in evidence and pave the way for the development of applications in clinical care.
Identifiants
pubmed: 35406394
pii: cancers14071622
doi: 10.3390/cancers14071622
pmc: PMC8996949
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : SIRIC-BRIO
ID : PhD Grant 2020-2021
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