Specific NLRP3 Inflammasome Assembling and Regulation in Neutrophils: Relevance in Inflammatory and Infectious Diseases.
Gasdermin-D
IL-18
IL-1β
NETosis
NLRP3
apoptosis
caspase-1
caspase-11
cell death
cryopyrin-associated periodic syndrome (CAPS)
gasdermin
inflammasome
macrophage
monocyte
neutrophil extracelluar traps (NETs)
neutrophils
pyroptosis
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
01 04 2022
01 04 2022
Historique:
received:
03
03
2022
revised:
27
03
2022
accepted:
30
03
2022
entrez:
12
4
2022
pubmed:
13
4
2022
medline:
14
4
2022
Statut:
epublish
Résumé
The NLRP3 inflammasome is a cytosolic multimeric protein platform that leads to the activation of the protease zymogen, caspase-1 (CASP1). Inflammasome activation mediates the proteolytic activation of pro-inflammatory cytokines (IL-1β and IL-18) and program cell death called pyroptosis. The pyroptosis is mediated by the protein executioner Gasdermin D (GSDMD), which forms pores at the plasma membrane to facilitate IL-1β/IL-18 secretion and causes pyroptosis. The NLRP3 inflammasome is activated in response to a large number of pathogenic and sterile insults. However, an uncontrolled inflammasome activation may drive inflammation-associated diseases. Initially, inflammasome-competent cells were believed to be limited to macrophages, dendritic cells (DC), and monocytes. However, emerging evidence indicates that neutrophils can assemble inflammasomes in response to various stimuli with functional relevance. Interestingly, the regulation of inflammasome in neutrophils appears to be unconventional. This review provides a broad overview of the role and regulation of inflammasomes-and more specifically NLRP3-in neutrophils.
Identifiants
pubmed: 35406754
pii: cells11071188
doi: 10.3390/cells11071188
pmc: PMC8997905
pii:
doi:
Substances chimiques
Inflammasomes
0
Interleukin-18
0
NLR Family, Pyrin Domain-Containing 3 Protein
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Cell Mol Immunol. 2017 Jan;14(1):118-126
pubmed: 26996064
Science. 2019 Apr 5;364(6435):
pubmed: 30872533
mBio. 2018 Feb 13;9(1):
pubmed: 29440572
J Exp Med. 2017 May 1;214(5):1333-1350
pubmed: 28424248
Proc Natl Acad Sci U S A. 1999 May 25;96(11):6261-6
pubmed: 10339575
PLoS One. 2016 Aug 10;11(8):e0160249
pubmed: 27509078
Immunity. 2010 Nov 24;33(5):657-70
pubmed: 21094463
Nat Immunol. 2019 May;20(5):527-533
pubmed: 30962589
Sci Immunol. 2017 Apr 28;2(10):
pubmed: 28626833
Nat Immunol. 2008 Aug;9(8):847-56
pubmed: 18604214
Front Immunol. 2019 Jan 10;9:3147
pubmed: 30687336
J Immunol. 2018 May 15;200(10):3341-3346
pubmed: 29661823
J Leukoc Biol. 2011 Feb;89(2):311-7
pubmed: 21106641
Br Med Bull. 2018 Dec 1;128(1):5-14
pubmed: 30137312
Nature. 2011 Sep 14;477(7366):596-600
pubmed: 21918512
Cells. 2021 Jun 15;10(6):
pubmed: 34203915
Nature. 2017 Jul 6;547(7661):99-103
pubmed: 28459430
J Immunol. 2016 Nov 15;197(10):4101-4109
pubmed: 27742831
Arthritis Res Ther. 2019 Nov 27;21(1):250
pubmed: 31775905
Sci Transl Med. 2011 Mar 9;3(73):73ra20
pubmed: 21389264
PLoS One. 2014 Oct 03;9(10):e108553
pubmed: 25279834
Immunol Rev. 2015 May;265(1):1-5
pubmed: 25879279
J Exp Med. 2018 Mar 5;215(3):827-840
pubmed: 29432122
Cell. 2010 Mar 19;140(6):821-32
pubmed: 20303873
Blood Adv. 2022 Apr 12;6(7):2001-2013
pubmed: 34991159
Sci Immunol. 2018 Aug 24;3(26):
pubmed: 30143555
Cell Rep. 2016 Jul 12;16(2):571-582
pubmed: 27346360
Blood Adv. 2021 Mar 9;5(5):1523-1534
pubmed: 33683342
Nature. 2009 Mar 26;458(7237):509-13
pubmed: 19158676
Cancer Cell. 2008 Nov 4;14(5):408-19
pubmed: 18977329
Nat Commun. 2020 May 5;11(1):2212
pubmed: 32371889
Mucosal Immunol. 2017 Jul;10(4):1056-1068
pubmed: 28051086
Nat Immunol. 2011 Oct 19;12(11):1035-44
pubmed: 22012443
Eur J Immunol. 2016 Apr;46(4):1004-10
pubmed: 27062120
Cell. 2004 Oct 29;119(3):431-43
pubmed: 15507213
Cell Rep. 2014 Jul 24;8(2):570-82
pubmed: 25043180
Trends Immunol. 2019 Jul;40(7):635-647
pubmed: 31160208
Nat Commun. 2014;5:3209
pubmed: 24492532
Ann Rheum Dis. 2019 Jul;78(7):957-966
pubmed: 31040119
Trends Immunol. 2010 Aug;31(8):318-24
pubmed: 20620114
Physiology (Bethesda). 2020 Mar 1;35(2):112-124
pubmed: 32027562
PLoS One. 2011;6(12):e28526
pubmed: 22174830
Eur J Immunol. 2018 Apr;48(4):584-592
pubmed: 29274245
Cancer Res. 2011 Apr 1;71(7):2411-6
pubmed: 21427354
J Exp Med. 2020 Dec 7;217(12):
pubmed: 32926097
Nature. 2014 Oct 9;514(7521):187-92
pubmed: 25119034
Sci Rep. 2020 Dec 14;10(1):21837
pubmed: 33318544
Cell Death Differ. 2004 Feb;11(2):143-53
pubmed: 14576767
Nat Methods. 2015 May;12(5):445-52
pubmed: 25775045
Sci Adv. 2021 Mar 5;7(10):
pubmed: 33674305
Sci Rep. 2017 Mar 27;7:45126
pubmed: 28345580
J Immunol. 2012 Nov 1;189(9):4231-5
pubmed: 23024281
Front Oncol. 2019 Nov 15;9:1146
pubmed: 31799175
Front Immunol. 2020 Jun 09;11:1121
pubmed: 32582201
Cell Rep. 2020 Jul 28;32(4):107967
pubmed: 32726630
J Immunol. 2004 Mar 1;172(5):2731-8
pubmed: 14978070
Trends Immunol. 2019 Nov;40(11):1035-1052
pubmed: 31662274
Blood. 1992 Oct 15;80(8):2012-20
pubmed: 1382715
PLoS Pathog. 2012;8(11):e1003047
pubmed: 23209417
Nat Med. 2015 Mar;21(3):248-55
pubmed: 25686105
Cell Res. 2020 Apr;30(4):315-327
pubmed: 32152420
Cell Rep. 2017 Feb 28;18(9):2077-2087
pubmed: 28249154
Eur J Immunol. 2014 Jul;44(7):2111-20
pubmed: 24687687
Nat Immunol. 2012 Nov;13(11):1118-28
pubmed: 23023392
Immunity. 2009 Jun 19;30(6):875-87
pubmed: 19501000
Thromb Haemost. 2012 Mar;107(3):597-8
pubmed: 22318427
J Immunol. 2015 Feb 15;194(4):1763-75
pubmed: 25609842
Nature. 2020 Dec;588(7839):688-692
pubmed: 33268895
Curr Opin Immunol. 2018 Oct;54:28-34
pubmed: 29883877
J Leukoc Biol. 2021 Mar;109(3):561-571
pubmed: 32531835
PLoS One. 2014 May 20;9(5):e96703
pubmed: 24846290
Sci Transl Med. 2013 Mar 27;5(178):178ra40
pubmed: 23536012
Immunity. 2018 Jan 16;48(1):35-44.e6
pubmed: 29195811
Nat Immunol. 2011 Dec 25;13(2):170-80
pubmed: 22197976
Nat Rev Immunol. 2018 Feb;18(2):134-147
pubmed: 28990587
Nat Commun. 2020 Nov 4;11(1):5566
pubmed: 33149141
Innate Immun. 2016 Feb;22(2):103-12
pubmed: 26610398
Arthritis Rheum. 2009 Dec;60(12):3651-62
pubmed: 19950280
Nat Med. 2012 Sep;18(9):1386-93
pubmed: 22922410
Arthritis Res Ther. 2016 Feb 11;18:47
pubmed: 26867643
Annu Rev Immunol. 2005;23:197-223
pubmed: 15771570
Biochemistry (Mosc). 2020 Oct;85(10):1178-1190
pubmed: 33202203
Nat Immunol. 2021 May;22(5):550-559
pubmed: 33707781
FEMS Microbiol Rev. 2017 Mar 1;41(2):139-157
pubmed: 27965320
PLoS Pathog. 2013;9(6):e1003452
pubmed: 23818853
Mod Rheumatol. 2018 May;28(3):513-517
pubmed: 28880687
Cell Host Microbe. 2015 Mar 11;17(3):357-368
pubmed: 25704009
Cell Rep. 2015 Feb 3;10(4):562-73
pubmed: 25620698
Nat Genet. 2001 Nov;29(3):301-5
pubmed: 11687797
Nat Rev Immunol. 2016 Jan;16(1):7-21
pubmed: 26655628
Clin Mol Allergy. 2011 May 31;9(1):10
pubmed: 21624140
Cell Rep. 2015 Dec 29;13(12):2829-2841
pubmed: 26711347
J Immunol. 2011 Feb 15;186(4):2529-34
pubmed: 21257968
Carcinogenesis. 2012 May;33(5):949-55
pubmed: 22425643
Eur J Immunol. 2012 Mar;42(3):710-5
pubmed: 22213227
J Leukoc Biol. 2012 Jan;91(1):167-81
pubmed: 21954284
Nat Rev Immunol. 2019 Aug;19(8):477-489
pubmed: 31036962
Cell Host Microbe. 2010 Dec 16;8(6):471-83
pubmed: 21147462
Nat Rev Immunol. 2011 Jul 25;11(8):519-31
pubmed: 21785456
Semin Immunopathol. 2015 Jul;37(4):377-85
pubmed: 25963520
Nat Rev Drug Discov. 2018 Aug;17(8):588-606
pubmed: 30026524
Cancer Cell. 2009 Sep 8;16(3):183-94
pubmed: 19732719
Nature. 2015 Oct 29;526(7575):666-71
pubmed: 26375259
Blood. 2016 May 5;127(18):2173-81
pubmed: 27002116
Immunol Rev. 2020 Sep;297(1):5-12
pubmed: 32856334
Cancer Immunol Immunother. 2019 Apr;68(4):673-685
pubmed: 30569204
Cell. 2020 Sep 17;182(6):1419-1440.e23
pubmed: 32810438
Cell. 2020 Sep 17;182(6):1401-1418.e18
pubmed: 32810439
J Exp Med. 2021 Oct 4;218(10):
pubmed: 34477811
Nature. 2015 Oct 29;526(7575):660-5
pubmed: 26375003
J Immunol. 2001 Jan 1;166(1):678-89
pubmed: 11123353
Nat Med. 2008 Apr;14(4):399-406
pubmed: 18327267
Annu Rev Cell Dev Biol. 2020 Oct 6;36:191-218
pubmed: 32663035
J Cell Biol. 2007 Jan 15;176(2):231-41
pubmed: 17210947
Sci Immunol. 2016 Aug;1(2):
pubmed: 28417112
Nat Commun. 2017 Jan 03;8:14128
pubmed: 28045099
Front Immunol. 2021 Jun 15;12:598943
pubmed: 34211455
Front Immunol. 2021 May 04;12:649235
pubmed: 34017331
Front Immunol. 2021 Sep 29;12:746032
pubmed: 34659244
Nat Immunol. 2006 Jun;7(6):576-82
pubmed: 16648852
Int J Mol Sci. 2019 Jul 06;20(13):
pubmed: 31284572
Lancet. 2016 Oct 22;388(10055):2039-2052
pubmed: 27112094
J Immunol. 2021 Apr 15;206(8):1913-1922
pubmed: 33712519
EMBO J. 2020 Jan 15;39(2):e103397
pubmed: 31793683
J Immunol. 2018 Nov 1;201(9):2767-2775
pubmed: 30266768
Nature. 2014 Sep 11;513(7517):237-41
pubmed: 24919149
Nat Commun. 2016 Feb 15;7:10555
pubmed: 26877061
J Biol Chem. 2014 Feb 21;289(8):5320-9
pubmed: 24398679
Acta Haematol. 2000;104(1):10-5
pubmed: 11111115
Nat Rev Immunol. 2016 Jul;16(7):407-20
pubmed: 27291964
Immunity. 2019 Jun 18;50(6):1412-1424.e6
pubmed: 31076360
Arthritis Res Ther. 2018 Aug 29;20(1):196
pubmed: 30157949
Immunology. 2016 Jun;148(2):125-39
pubmed: 26878338
Blood. 2002 Aug 1;100(3):854-61
pubmed: 12130495
PLoS Pathog. 2012;8(3):e1002638
pubmed: 22479187
Sci Rep. 2017 Aug 10;7(1):7743
pubmed: 28798364
Immunity. 2016 Apr 19;44(4):833-46
pubmed: 27037191
Semin Immunol. 2016 Apr;28(2):119-28
pubmed: 27151246
Blood. 2021 Sep 2;138(9):806-810
pubmed: 34473230
Sci Immunol. 2018 Aug 24;3(26):
pubmed: 30143554
PLoS One. 2016 Apr 13;11(4):e0153567
pubmed: 27073889
Blood. 2010 Jul 29;116(4):625-7
pubmed: 20410504
Methods Mol Biol. 2016;1458:179-93
pubmed: 27581022