SOAT1: A Suitable Target for Therapy in High-Grade Astrocytic Glioma?
IDH1/2
SOAT1
astrocytoma
glioblastoma
lipid droplets
mitotane
targeted therapy
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
28 Mar 2022
28 Mar 2022
Historique:
received:
28
01
2022
revised:
23
03
2022
accepted:
26
03
2022
entrez:
12
4
2022
pubmed:
13
4
2022
medline:
14
4
2022
Statut:
epublish
Résumé
Targeting molecular alterations as an effective treatment for isocitrate dehydrogenase-wildtype glioblastoma (GBM) patients has not yet been established. Sterol-O-Acyl Transferase 1 (SOAT1), a key enzyme in the conversion of endoplasmic reticulum cholesterol to esters for storage in lipid droplets (LD), serves as a target for the orphan drug mitotane to treat adrenocortical carcinoma. Inhibition of SOAT1 also suppresses GBM growth. Here, we refined SOAT1-expression in GBM and
Identifiants
pubmed: 35409086
pii: ijms23073726
doi: 10.3390/ijms23073726
pmc: PMC8998855
pii:
doi:
Substances chimiques
Isocitrate Dehydrogenase
EC 1.1.1.41
Sterol O-Acyltransferase
EC 2.3.1.26
sterol O-acyltransferase 1
EC 2.3.1.26
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
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