PDGF/PDGFR: A Possible Molecular Target in Scleroderma Fibrosis.
PDGF receptor (PDGFR)
PDGF/PDGFR targeting therapy
anti-PDGFR autoantibodies
fibrosis
platelet-derived growth factor (PDGF)
scleroderma (SSc)
systemic sclerosis (SSc)
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
31 Mar 2022
31 Mar 2022
Historique:
received:
28
02
2022
revised:
28
03
2022
accepted:
30
03
2022
entrez:
12
4
2022
pubmed:
13
4
2022
medline:
14
4
2022
Statut:
epublish
Résumé
Systemic sclerosis (SSc) is a clinically heterogeneous disorder of the connective tissue characterized by vascular alterations, immune/inflammatory manifestations, and organ fibrosis. SSc pathogenesis is complex and still poorly understood. Therefore, effective therapies are lacking and remain nonspecific and limited to disease symptoms. In the last few years, many molecular and cellular mediators of SSc fibrosis have been described, providing new potential options for targeted therapies. In this review: (i) we focused on the PDGF/PDGFR pathway as key signaling molecules in the development of tissue fibrosis; (ii) we highlighted the possible role of stimulatory anti-PDGFRα autoantibodies in the pathogenesis of SSc; (iii) we reported the most promising PDGF/PDGFR targeting therapies.
Identifiants
pubmed: 35409263
pii: ijms23073904
doi: 10.3390/ijms23073904
pmc: PMC8999630
pii:
doi:
Substances chimiques
Autoantibodies
0
Platelet-Derived Growth Factor
0
Receptor, Platelet-Derived Growth Factor alpha
EC 2.7.10.1
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Marche Biobank Project
ID : POR FESR 2014 - 2020
Références
Fibrogenesis Tissue Repair. 2013 May 10;6(1):10
pubmed: 23663505
Biochem Biophys Res Commun. 2016 Sep 2;477(4):667-672
pubmed: 27349873
J Scleroderma Relat Disord. 2020 Mar;5(2 Suppl):6-16
pubmed: 35382227
Arthritis Res Ther. 2014 Jul 08;16(4):R144
pubmed: 25007944
Curr Opin Rheumatol. 2021 Mar 1;33(2):122-127
pubmed: 33481429
Handb Exp Pharmacol. 2017;243:355-369
pubmed: 27718060
Arthritis Res Ther. 2015 Aug 18;17:213
pubmed: 26283632
Chemother Res Pract. 2014;2014:357027
pubmed: 24963404
Hum Immunol. 2017 Feb;78(2):153-165
pubmed: 27984087
Cytokine Growth Factor Rev. 2004 Aug;15(4):205-13
pubmed: 15207812
JAMA. 2020 Apr 7;323(13):1266-1276
pubmed: 32259228
Nature. 2016 Dec 8;540(7632):276-279
pubmed: 27894125
Arthritis Res Ther. 2015 Mar 23;17:73
pubmed: 25885360
Dev Cell. 2009 Feb;16(2):303-13
pubmed: 19217431
Heart Rhythm. 2013 Jul;10(7):1044-51
pubmed: 23499624
Ann Transl Med. 2021 Dec;9(23):1728
pubmed: 35071422
Rheumatology (Oxford). 2013 Nov;52(11):1963-72
pubmed: 23893664
N Engl J Med. 2006 Jun 22;354(25):2667-76
pubmed: 16790699
Pathol Int. 2017 May;67(5):235-246
pubmed: 28393435
Arthritis Rheumatol. 2015 Jul;67(7):1891-903
pubmed: 25808833
Biophys Rev. 2020 Aug;12(4):805-815
pubmed: 32691300
Cells. 2020 Apr 03;9(4):
pubmed: 32260126
Structure. 2017 Feb 7;25(2):341-352
pubmed: 28111021
Cell Mol Life Sci. 2021 Apr;78(8):3867-3881
pubmed: 33449152
Anal Biochem. 2017 Jul 1;528:26-33
pubmed: 28450104
J Autoimmun. 2020 Jul;111:102444
pubmed: 32284212
Semin Arthritis Rheum. 2013 Feb;42(4):377-90
pubmed: 22789835
Biochemistry. 2015 Mar 17;54(10):1918-29
pubmed: 25707433
Biochem Soc Trans. 2020 Jun 30;48(3):1167-1176
pubmed: 32369556
Onco Targets Ther. 2018 Feb 16;11:833-842
pubmed: 29497315
Clin Rheumatol. 2020 Jan;39(1):27-36
pubmed: 31111363
J Dermatol. 2010 Jan;37(1):42-53
pubmed: 20175839
Physiol Rev. 1999 Oct;79(4):1283-316
pubmed: 10508235
Front Pharmacol. 2022 Feb 03;13:826839
pubmed: 35185577
Front Immunol. 2021 Nov 29;12:745308
pubmed: 34912333
Cancer Res. 2008 Jun 15;68(12):4774-82
pubmed: 18559524
Mol Aspects Med. 2018 Aug;62:75-88
pubmed: 29137923
EMBO J. 1992 Nov;11(11):3921-6
pubmed: 1396586
Mol Aspects Med. 2018 Aug;62:44-62
pubmed: 29155002
N Engl J Med. 2014 May 29;370(22):2071-82
pubmed: 24836310
Nat Rev Rheumatol. 2019 Dec;15(12):705-730
pubmed: 31712723
Biomedicines. 2022 Jan 12;10(1):
pubmed: 35052842
Curr Opin Immunol. 2007 Dec;19(6):640-5
pubmed: 18083509
Transl Res. 2021 May;231:139-158
pubmed: 33422651
Exp Cell Res. 2016 Dec 10;349(2):282-290
pubmed: 27816607
Front Immunol. 2017 Feb 08;8:75
pubmed: 28228756
N Engl J Med. 2019 Oct 17;381(16):1596-1597
pubmed: 31618556
Lancet Respir Med. 2020 May;8(5):453-460
pubmed: 32145830
Arthritis Rheumatol. 2016 Sep;68(9):2263-73
pubmed: 27111463
J Exp Med. 1992 May 1;175(5):1227-34
pubmed: 1314885
Mayo Clin Proc. 2006 Sep;81(9):1241-57
pubmed: 16970222
Front Med (Lausanne). 2022 Jan 18;8:822804
pubmed: 35118101
Ann Rheum Dis. 2016 May;75(5):883-90
pubmed: 25858641
J Rheumatol. 1995 Oct;22(10):1876-83
pubmed: 8991985
J Vis Exp. 2019 Apr 30;(146):
pubmed: 31107440
Methods Mol Biol. 2017;1627:1-23
pubmed: 28836191
Clin Exp Rheumatol. 2013 Mar-Apr;31(2 Suppl 76):3-7
pubmed: 23910606
Ann Rheum Dis. 2017 Aug;76(8):1327-1339
pubmed: 27941129
Exp Eye Res. 2010 Mar;90(3):376-81
pubmed: 19931527
Cell. 1993 Apr 23;73(2):321-34
pubmed: 7682895
PLoS One. 2017 Nov 9;12(11):e0187580
pubmed: 29121645
Arthritis Rheum. 2007 Jan;56(1):311-22
pubmed: 17195235
Cell Physiol Biochem. 2018;51(3):1461-1479
pubmed: 30485861
Biomedicines. 2021 Oct 14;9(10):
pubmed: 34680587
J Scleroderma Relat Disord. 2020 Mar;5(2 Suppl):41-47
pubmed: 35382223
J Invest Dermatol. 2019 Feb;139(2):439-447
pubmed: 30273596
Biochim Biophys Acta. 2013 Oct;1834(10):2176-86
pubmed: 23137658
Immunol Lett. 2018 Mar;195:83-87
pubmed: 29032187
Cell. 2007 Jul 27;130(2):323-34
pubmed: 17662946
J Clin Invest. 2004 Nov;114(9):1308-16
pubmed: 15520863
Mol Cancer Ther. 2012 Nov;11(11):2473-82
pubmed: 22933705
N Engl J Med. 2019 Oct 31;381(18):1718-1727
pubmed: 31566307
Gene. 2017 May 30;614:1-7
pubmed: 28267575
Cell. 2021 Mar 4;184(5):1232-1244.e16
pubmed: 33626330
PLoS One. 2013;8(4):e60414
pubmed: 23577108
Nat Cell Biol. 2001 Jun;3(6):580-6
pubmed: 11389443
Genes Dev. 2008 May 15;22(10):1276-312
pubmed: 18483217
Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11307-12
pubmed: 20534510
J Invest Dermatol. 2017 Aug;137(8):1671-1681
pubmed: 28433542