The Transition of Photoreceptor Guanylate Cyclase Type 1 to the Active State.

GCAP cGMP calcium-binding proteins guanylate cyclase molecular-dynamics simulation phototransduction protein geometry retina retinal degeneration vision

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
05 Apr 2022
Historique:
received: 22 02 2022
accepted: 02 04 2022
entrez: 12 4 2022
pubmed: 13 4 2022
medline: 14 4 2022
Statut: epublish

Résumé

Membrane-bound guanylate cyclases (GCs), which synthesize the second messenger guanosine-3', 5'-cyclic monophosphate, differ in their activation modes to reach the active state. Hormone peptides bind to the extracellular domain in hormone-receptor-type GCs and trigger a conformational change in the intracellular, cytoplasmic part of the enzyme. Sensory GCs that are present in rod and cone photoreceptor cells have intracellular binding sites for regulatory Ca

Identifiants

pubmed: 35409388
pii: ijms23074030
doi: 10.3390/ijms23074030
pmc: PMC8999790
pii:
doi:

Substances chimiques

Guanylate Cyclase-Activating Proteins 0
Hormones 0
Guanylate Cyclase EC 4.6.1.2
Alanine OF5P57N2ZX

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Deutsche Forschungsgemeinschaft
ID : GRK1885
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB1372
Organisme : Volkswagen Foundation
ID : Lichtenberg Professorship
Organisme : MWK Lower Saxony
ID : SMART

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Auteurs

Manisha Kumari Shahu (MK)

Division of Biochemistry, Department of Neuroscience, University of Oldenburg, 26111 Oldenburg, Germany.

Fabian Schuhmann (F)

Institute of Physics, University of Oldenburg, 26111 Oldenburg, Germany.

Alexander Scholten (A)

Division of Biochemistry, Department of Neuroscience, University of Oldenburg, 26111 Oldenburg, Germany.

Ilia A Solov'yov (IA)

Institute of Physics, University of Oldenburg, 26111 Oldenburg, Germany.
Research Centre for Neurosensory Science, University of Oldenburg, 26111 Oldenburg, Germany.

Karl-Wilhelm Koch (KW)

Division of Biochemistry, Department of Neuroscience, University of Oldenburg, 26111 Oldenburg, Germany.
Research Centre for Neurosensory Science, University of Oldenburg, 26111 Oldenburg, Germany.

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